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Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth.
Life Sci Space Res (Amst)
February 2025
Department of Radiation Oncology, Wake Forest University School of Medicine. Winston-Salem, NC, USA. Electronic address:
Reduced weight-bearing during spaceflight has been associated with musculoskeletal degradation that risks astronaut health and performance in transit and upon reaching deep space destinations. Previous rodent experiments aboard the international space station (ISS) have identified that the spaceflight-induced molecular arthritic phenotype was characterized with an increase in oxidative stress. This study evaluated if treatment with a superoxide dismutase (SOD) mimetic on orbit could prevent spaceflight-induced damage to the knee and hip articular cartilage, and the menisci in rodents.
View Article and Find Full Text PDFIntegrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans.
Life Sci Space Res (Amst)
February 2025
Institute of Environmental Systems Biology, College of Environmental Science and Engineering, Dalian Maritime University, Dalian, 116026, Liaoning, PR China.
The space environment presents unique stressors, such as microgravity and space radiation, which can induce molecular and physiological changes in living organisms. To identify key reproducible transcriptomic features and explore potential biological roles in space-flown C. elegans, we integrated transcriptomic data from C.
View Article and Find Full Text PDFLow-vibration cryogenic test facility for next generation of ground-based gravitational-wave observatories.
Rev Sci Instrum
January 2025
OzGrav-ANU, ARC Centre for Gravitational Astrophysics, College of Science, The Australian National University, Canberra ACT2601, Australia.
We present the design and commissioning of a cryogenic low-vibration test facility that measures displacement noise from a gram-scale silicon cantilever at the level of 10-16m/Hz at 1 kHz. This sensitivity is necessary for future tests of thermal noise models on cross sections of silicon suspension samples proposed for future gravitational-wave detectors. A volume of ∼36 l is enclosed by radiation shields cooling an optical test cavity that is suspended from a multi-stage pendulum chain providing isolation from acoustic and environmental noise.
View Article and Find Full Text PDFQuantitative Assessment of Postural Influence on Lung Function Using Deformable Image Registration-Based Breath-Hold CT Ventilation Imaging.
Cureus
December 2024
Department of Radiological Technology, Fujieda Municipal General Hospital, Fujieda, JPN.
Purpose This study aimed to clarify which positions are beneficial for patients with pathological lung diseases, such as acute respiratory distress syndrome, by obtaining lung ventilation and deformable vector field (DVF) images using Deformable Image Registration (DIR). Methods Thirteen healthy volunteers (5 female, 8 male) provided informed consent to participate to observe changes in normal lungs. DIR imaging was processed using the B-spline algorithm to obtain BH-CTVI (inhale, exhale) in four body positions (supine, prone, right lateral, left lateral) using DIR-based breath-hold CT ventilation imaging (BH-CTVI).
View Article and Find Full Text PDFPlants will form the basis of artificial ecosystems in space exploration and the creation of bases on other planets. Astrophysical factors, such as ionizing radiation (IR), magnetic fields (MF) and gravity, can significantly affect the growth and development of plants beyond Earth. However, to date, the ways in which these factors influence plants remain largely unexplored.
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