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Schistosomiasis treatment in young children: a welcome step towards deployment of the paediatric praziquantel formulation.
Int Health
January 2025
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
It is an awkward fact that effective public health control of schistosomiasis in Africa has yet to deliver a fully comprehensive intervention for appropriate anthelmintic treatment of those preschool-age children and infants with active infection(s) and/or insidious disease. Over the last decade, despite the steady progress of the Pediatric Praziquantel Consortium in developing a monoenantiomeric oral dispersible tablet, future challenges remain in securing its deployment and implementation at scale. This commentary provides a forward-looking critique for the international community, reminding us of this unfortunate treatment gap, and seeks to encourage commensurate action on ameliorating this overlooked medical inequity.
View Article and Find Full Text PDFDaily executive functioning in adults with pediatric hemispherectomy.
Epilepsy Res
January 2025
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA 91101, United States; International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5), Pasadena, CA 91106, United States; California Institute of Technology, Division of Humanities and Social Sciences, Pasadena, CA 91125, United States. Electronic address:
Background And Aims: For young children with intractable epilepsy caused by congenital abnormalities or acquired cortical lesions, pediatric hemispherectomy surgery (pHS) may offer the only path to seizure remediation. Although some sensory and motor outcomes of pHS are highly predictable, the long-term cognitive and functional sequelae of pHS are far more variable. With the aim of identifying potential post-pHS intervention targets, the current study examined daily executive functioning and self-awareness in adults with pHS and broadly intact cognitive outcomes (indicated by average or above performance on intelligence tests).
View Article and Find Full Text PDFBolus-Tracked Biphasic Contrast-Enhanced CT Imaging Following Microwave Liver Ablation Improves Ablation Zone Conspicuity and Semi-automatic Segmentation Quality.
Cardiovasc Intervent Radiol
January 2025
Interventional Radiology, The Royal Marsden, 203 Fulham Road, London, SW36JJ, UK.
Purpose: Contrast-enhanced CT (CECT) may be performed immediately following microwave liver ablation for assessment of ablative margins. However, practices and protocols vary among institutions. Here, we compare a standardized bolus-tracked biphasic CECT protocol and compare this with a single venous phase fixed delay protocol for ablation zone (AZ) assessment.
View Article and Find Full Text PDFArtificial intelligence and stroke imaging.
Curr Opin Neurol
February 2025
High Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London, UK.
Article Synopsis
- The review highlights the complexity of stroke, driven by disruptions in blood supply and complicated by the neural and vascular systems' interactions.
- Advances in machine vision and deep learning are improving predictive tools for stroke, but their clinical impact is limited by real-world data challenges.
- Although AI's potential benefits for stroke care are clear, the best approaches for practical application are still being explored, with deep generative models seen as a promising avenue for innovation.
An Estimate of Wolverine Density for the Canadian Province of Alberta.
Ecol Evol
January 2025
Government of Alberta, Forestry and Parks Canmore Alberta Canada.
Article Synopsis
- Wolverines have faced significant range reduction globally, with complete extirpation from eastern Canada and some western prairie regions.
- In Alberta, where they are designated for conservation, researchers aimed to estimate wolverine abundance using existing density data and habitat relationships.
- Results indicated approximately 955 wolverines in the province, with only 544 classified as adults, suggesting a need for a reassessment of their conservation status and related protective measures.
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