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Repetitive grooming behavior following aversive stimulus coincides with a decrease in anterior hypothalamic area activity.
eNeuro
January 2025
Neuronal Circuits and Behavior Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, U.S.A.
The anterior hypothalamic area (AHA) is a key brain region for orchestrating defensive behaviors. Using in vivo calcium imaging in mice, we observed that AHA neuronal activity increases during foot shock delivery and foot-shock associated auditory cues. We found that following shock-induced increases in AHA activity, a decrease in activity coincides with the onset of grooming behavior.
View Article and Find Full Text PDFThe role of UV-induced cutaneous matrix metalloproteinases and mi-RNAs in the pathogenesis of lupus erythematosus.
J Transl Autoimmun
June 2025
Department of Dermatology, University Medical Center Regensburg, 93042, Regensburg, Germany.
Cutaneous (CLE) and systemic lupus erythematosus (SLE) are autoimmune diseases with a multifactorial pathogenesis. Ultraviolet radiation (UVR) is the most important trigger of CLE; however, the degree of photosensitivity varies between the clinical subtypes. The expression of matrix metalloproteinases (MMPs)-important enzymes involved in skin turnover and homeostasis-is modulated by UVR.
View Article and Find Full Text PDFLongitudinal evaluation of cotton wool spot following rapid glycemic improvement using wide-field multimodal imaging.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Shinshu University School of Medicine, Japan.
Purpose: To report a case of a diabetic patient undergoing rapid glycemic improvement characterized by the development and resolution of cotton wool spot (CWS), with detailed structural and vascular assessment using wide-field multimodal imaging, including wide-field color fundus photography and wide-field optical coherence tomography angiography (OCTA).
Observations: A 47-year-old man with poorly controlled Type 2 diabetes mellitus developed CWS in his right eye 3 months after initiating insulin therapy, which coincided with a significant reduction in HbA1c levels. Wide-field color fundus photography and wide-field OCTA were performed before, during, and after CWS appeared.
Automatic tool for the reconciliation of serious adverse events for pharmacovigilance: design and implementation of Reconciliaid.
Ther Adv Drug Saf
January 2025
Department of Epidemiology, Biostatistics and Health Data, Centre Antoine Lacassagne, Nice, France.
Background: Reporting serious adverse events (SAEs) is crucial to reduce or avoid toxicities that can lead to major consequences for patient's health due to treatments tested in clinical trials. Its exhaustiveness is often inadequate, and we observe discrepancies between data published by pharmacovigilance organizations and clinical databases.
Objectives: While the process of reconciliation aims at reducing these differences, it remains a very time-consuming and imprecise task.
[A CASE OF LEFT SPINAL ERECTOR SPINAE COMPARTMENT SYNDROME AFTER RETROPERITONEOSCOPIC RIGHT NEPHRECTOMY FOR WHICH DECOMPRESSIVE FASCIOTOMY WAS EFFECTIVE].
Nihon Hinyokika Gakkai Zasshi
January 2025
Department of Urology, Faculty of Medicine, The University of Tokyo.
The patient was a male in his 60s who underwent a retroperitoneoscopic right nephrectomy for a diagnosis of right renal cell carcinoma (cT3aN0M0). During surgery, the patient was positioned in the left lateral recumbent, jackknife position. A blood test of the day after surgery showed an abnormally high CK level of 23,038 U/L.
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