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Unbound bilirubin and risk of severe neurodevelopmental impairment in extremely low birthweight newborns.
Pediatr Res
January 2025
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Background: Unbound bilirubin (UB) was measured on day 5 ± 1 in 1101 ELBW newborns in the Aggressive vs Conservative Phototherapy randomized controlled trial. We accessed this dataset to quantify the UB-mediated risk of severe neurodevelopmental impairment (sNDI) in extremely low birthweight (ELBW) newborns.
Methods: UB levels were standardized within laboratories as z-score percentiles.
Comparison of transcutaneous bilirubin under patch-covered skin with total serum bilirubin in neonates undergoing phototherapy.
J Trop Pediatr
December 2024
Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India.
Transcutaneous bilirubinometry (TcB) is a recognized tool to monitor neonatal hyperbilirubinemia, demonstrating a high correlation with total serum bilirubin (TSB) before phototherapy. However, once phototherapy is started, TcB may become unreliable. To evaluate the correlation and agreement of TcB measured under variously patched skin at different sites (a coin over the sternum, eye shield over the forehead, and diaper area at the back) with TSB.
View Article and Find Full Text PDFA rare case of late developing anti-E antibody in a pregnant female leading to severe hemolytic disease of the newborn: A missed follow-up in COVID-19 epoch.
Asian J Transfus Sci
November 2023
Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
With the use of Anti-D prophylaxis for rhesus D-negative pregnant women, other Rh and non-Rh allo-antibodies have become relatively more important. The index case reports severe hemolytic disease of the newborn due to anti-E antibody in a full-term baby boy born to a COVID-19-positive mother. The antibody screening of the mother performed during Booking of pregnancy at 9 week of gestation was negative.
View Article and Find Full Text PDFHyperbilirubinemia in Neonates with Blood Group Incompatibilities - a bane or a boon for the management.
Transfus Clin Biol
January 2025
Department of Community Medicine, SCB Medical College & Hospital, Cuttack, Odisha, India. Electronic address:
Objectives: Neonatal hyperbilirubinemia, or newborn jaundice, is a common condition caused by high bilirubin levels. Blood group incompatibility between mother and baby is a major cause. This study examined the link between different blood group incompatibilities and their management in newborns with jaundice.
View Article and Find Full Text PDFTowards a pharmacokinetic approach to neonatal phototherapy.
Pediatr Res
January 2025
Lucile Salter Packard Children's Hospital, Stanford Children's Health. Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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