AI Article Synopsis
- Research was conducted on cystathionine synthase levels in skin fibroblasts from a patient with pyridoxine-non-responsive homocystinuria, comparing them to normal and heterozygous samples.
- Synthase activity varied based on both the duration of culture and the composition of the culture media, indicating that environmental factors influence the results.
- The study concluded that cell culture methods should be used with caution when defining normal, heterozygous, and homozygous states in relation to homocystinuria.
Article Abstract
The levels of cystathionine synthase have been examined in cultured skin fibroblasts obtained from a patient suffering from pyridoxine-non-responsive homocystinuria and compared with the normal and heterozygous states. Levels of synthase activity were found to vary with time in culture and composition of culture media. The physical properties of normal and abnormal synthase activities were markedly different. It has been concluded that caution has to be exercised when using cell culture methods for the purpose of defining normal, heterozygous and homozygous states with reference to homocystinuria.
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| http://dx.doi.org/10.1016/0009-8981(76)90317-x | DOI Listing |
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