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Combining Multifrequency Magnetic Resonance Elastography With Automatic Segmentation to Assess Renal Function in Patients With Chronic Kidney Disease.
J Magn Reson Imaging
January 2025
Department of Radiology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chinese Medicine Hospital), Shenzhen, China.
Background: Multifrequency MR elastography (mMRE) enables noninvasive quantification of renal stiffness in patients with chronic kidney disease (CKD). Manual segmentation of the kidneys on mMRE is time-consuming and prone to increased interobserver variability.
Purpose: To evaluate the performance of mMRE combined with automatic segmentation in assessing CKD severity.
Preoperative MRI to Predict Upstaging of DCIS to Invasive Cancer at Surgery.
Ann Surg Oncol
January 2025
Department of Radiology, University of Washington, Seattle, WA, USA.
Background: Ductal carcinoma in situ (DCIS) is overtreated, in part because of inability to predict which DCIS cases diagnosed at core needle biopsy (CNB) will be upstaged at excision. This study aimed to determine whether quantitative magnetic resonance imaging (MRI) features can identify DCIS at risk of upstaging to invasive cancer.
Methods: This prospective observational clinical trial analyzed women with a diagnosis of DCIS on CNB.
Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling.
Front Neurosci
January 2025
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Background And Purpose: Irritable bowel syndrome (IBS) is a common bowel-brain interaction disorder whose pathogenesis is unclear. Many studies have investigated abnormal changes in brain function in IBS patients. In this study, we analyzed the dynamic changes in brain function in IBS patients using a Hidden Markov Model (HMM).
View Article and Find Full Text PDFDihydroaurones and Isoflavan Derivatives from the Roots of .
J Nat Prod
January 2025
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, IT-84084 Fisciano, Salerno, Italy.
As a continuation of our pharmacognostic studies on different species growing in Türkiye, the phytochemical investigation of the roots of Hub.-Mor., a licorice species endemic to Türkiye, was carried out.
View Article and Find Full Text PDFRibose Sugar Alters Conformational Sampling of G•T Mismatched Duplex DNA.
Chem Asian J
January 2025
Indian Institute of Science Education and Research Bhopa;, Chemistry, IISER Bhopal, Chemistry, #229,, Academic Building #2, Bhopal bypass road, Bhauri, 462066, Bhopal, INDIA.
Polymerases erroneously incorporate Guanine-Thymine (dG•dT) mismatches in genomic DNA that further evades repair by transient sampling of tautomeric/ionic states compromising fidelity of repairing dG•dT mismatches. In conjunction, significant frequency of ribose (mis)incorporation in duplex DNA permits for misincorporated-mismatch in the genome. Ribose incorporated G(rG) mismatched with T(rG•dT) is the most stable across all misincorporated-mismatch calling into question the conformational consequences of the ribose sugar in addition to the mismatch.
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