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Overexpression of Drosophila NUAK or Constitutively-Active Formin-Like Promotes the Formation of Aberrant Myofibrils.
Cytoskeleton (Hoboken)
January 2025
Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Muscle development and maintenance is central to the normal functioning of animals. Muscle tissues exhibit high levels of activity and require the dynamic turnover of proteins. An actomyosin scaffold functions with additional proteins comprising the basic contractile subunit of striated muscle, known as the sarcomere.
View Article and Find Full Text PDFState-of-the-art laser frequency stabilization is limited by miniscule length changes caused by thermal noise. In this work, a cavity-length-insensitive frequency stabilization scheme is implemented using strong dispersion in a 21 mm long cavity with a europium-ion-doped spacer of yttrium orthosilicate. A number of limiting factors for slow light laser stabilization are evaluated, including the inhomogeneous and homogeneous linewidth of the ions, the deterioration of spectral windows, and the linewidth of the cavity modes.
View Article and Find Full Text PDFFilm-coupled plasmonic resonators offer efficient platforms for light enhancement due to the excitation of gap surface plasmons (GSPs) at metal-insulator-metal interfaces, where electromagnetic energy is stored within the spacer. In applications like biosensing and spontaneous emission control, spatial overlap between the target molecule and plasmonic hotspots is essential. Here, we propose utilizing the controllable, efficient light enhancement capabilities of a specifically designed GSP disk resonator for biosensing and spontaneous emission enhancement.
View Article and Find Full Text PDFThere has been an increasing need for small, low-cost, and low-power consumption optical transceivers for short-reach fiber links. Waveguide-integrated photodetectors (PDs) with wide bandwidth and high responsivity on Si photonics platforms are an essential element for these applications. We have fabricated an O-band membrane PD which is suitable for integration with high-performance III-V-based membrane devices such as lasers and modulators, and passive waveguide circuits on the Si photonics platforms.
View Article and Find Full Text PDFDiagnostic utility of chest wall vessel involvement sign on ultra-high-resolution CT for primary lung cancer infiltrating the chest wall.
Eur Radiol
January 2025
Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Objectives: Chest wall infiltration in primary lung cancer affects the surgical and therapeutic strategies. This study evaluates the efficacy of the chest wall vessel involvement in subpleural lung cancer (CWVI) on ultra-high-resolution CT (UHR-CT) for detecting chest wall invasion.
Materials And Methods: A retrospective analysis of lung cancer cases with confirmed pleural and chest wall invasion was conducted from November 2019 to April 2022.
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