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Injectable thermosensitive antibiotic-laden chitosan hydrogel for regenerative endodontics.
Bioact Mater
April 2025
Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Injectable biomaterials, such as thermosensitive chitosan (CH)-based hydrogels, present a highly translational potential in dentistry due to their minimally invasive application, adaptability to irregular defects/shapes, and ability to carry therapeutic drugs. This work explores the incorporation of azithromycin (AZI) into thermosensitive CH hydrogels for use as an intracanal medication in regenerative endodontic procedures (REPs). The morphological and chemical characteristics of the hydrogel were assessed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR).
View Article and Find Full Text PDFSilver nanoparticle-loaded Konjac Glucomannan/silk fibroin composite hydrogels for enhanced wound healing.
Int J Biol Macromol
January 2025
School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Hydrogel dressings with good biocompatibility and extracellular matrix mimetic structure are important for the treatment of skin wounds. In this study, antimicrobial silver nanoparticles (Ag NPs) loaded with konjac glucomannan and silk fibroin (KGM/SF) composite hydrogel were used as a dressing for wound healing. The uniform distribution of Ag NPs on the surface of the hydrogels imparts excellent antibacterial properties to KGM/SF composite hydrogels.
View Article and Find Full Text PDFDirectional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects.
Adv Mater
January 2025
Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long-term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situation. Considering the complex microenvironment and persistent mechanisms mediated by resistant bacteria, it is crucial to develop an implant with enhanced osseointegration and sustained and effective infection clearance effects.
View Article and Find Full Text PDFTemplate-free synthesis of single-crystal SrTiO nanocages for photocatalytic overall water splitting.
Chem Commun (Camb)
January 2025
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
In this study, we present a novel approach to achieve the template-free fabrication of nanocage-shaped SrTiO (N-STO) single crystals molten salt flux treatment. Systematic characterizations demonstrate the high crystallinity and low defect density of N-STO. The N-STO single crystals enable overall water splitting (OWS) with hydrogen and oxygen evolution rates of 100.
View Article and Find Full Text PDFSide Reaction Turned Positive: Synchronous OER Manipulating the Electrocatalytic Properties of Anodic Electrodeposited Lead Dioxide.
Small
January 2025
Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
The preparation and modification of porous electrodes are an important component of the new generation electrochemical oxidation technology. Rapid preparation of porous electrodes can be easily achieved by synchronous oxygen bubble electrodeposition. However, according to the reaction mechanism of lead dioxide anodic electrodeposition, there is bound to be a competitive reaction of adsorbed hydroxyl radicals in the oxygen bubble template method, which means that synchronous OER impacts both the surface morphology and potentially the crystalline structure of the metal oxides.
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