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Review: A hierarchical research model to foster dialog between grazing ecology and beef cow energetics to support ecological intensification of native grassland.
Animal
November 2024
Centro Universitario de la Región Este, Universidad de la República, Uruguay.
Cow-calf systems grazing native grasslands must transition toward improved economic performance simultaneously with the conservation and improvement of ecosystem services they provide. We present an innovation model with this objective based on a hierarchical model that links functional relationships between state variables, grazing experiments and its validation, and co-innovation at the farm level. This paper describes the hypotheses, designs, and results of the studies, and the role of grazing ecology and herbivore nutrition to support the process of ecological intensification of livestock systems on native grasslands.
View Article and Find Full Text PDFEfflux transporters in drug disposition during pregnancy.
Drug Metab Dispos
January 2025
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Evidence-based dose selection of drugs in pregnant women has been lacking because of challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are administered off-label during pregnancy based on data obtained from nonpregnant women. During pregnancy, drug transporters play an important role in drug disposition along with known gestational age-dependent changes in physiology and drug-metabolizing enzymes.
View Article and Find Full Text PDFPretreatment of enzymatic hydrolysis lignin based on deep eutectic solvent containing a reversibly-soluble base.
Int J Biol Macromol
January 2025
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:
The pretreatment with green deep eutectic solvents (DESs) is conducive to realizing the high-efficiency utilization of lignin at a low cost. In this study, an innovative choline chloride/urea/calcium hydroxide (ChCl/UR/Ca(OH)) DES containing a reversibly-soluble base Ca(OH) was developed for the pretreatment of enzymatic hydrolysis lignin (EHL). The lignin pretreatment effects of the proposed ChCl/UR/Ca(OH) DES were compare with a series of DESs.
View Article and Find Full Text PDFRecent advances of intelligent polymer gels as active carriers for medical imaging-guided cancer therapy: A review.
Int J Biol Macromol
January 2025
The Radiology Department of Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Cancer is a major global health challenges and various imaging-guided techniques are gaining prominence for its diagnosis and therapy with the advantages of high sensitivity, spatial resolution, and quantitative capability. The effectiveness of these approaches mainly relies on the establishment of a responsive platform. The intelligent polymer gel composites as the active carriers have drawn considerable attention owing to their outstanding versatility, three-layer network structure, mechanical adjustability and so forth, which may be contribute to loading drug, imaging probe, and targeting biomarkers in medical imaging-guided cancer therapy (IGCT).
View Article and Find Full Text PDFFish gut symbiotic bacterium Bacillus thuringiensis: RSM optimization for its extracellular lipase enzyme production, lipase-protein purification, characterization, and docking analysis.
Int J Biol Macromol
January 2025
State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu 610059, Sichuan, China.
Lipase enzymes play a vital role in digestion and nutrient metabolism in host organisms, with symbiotic bacteria producing abundant enzymes, carbohydrates, vitamins, and other nutrients. This study aimed to isolate, identify, and screen lipase-producing bacteria from the gut of Systomus sarana, optimize enzyme production using Response Surface Methodology (RSM), and characterize the extracted lipase protein. A total of 11 bacterial strains were isolated and identified through 16S rRNA sequencing.
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