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In this work, we investigated individual bacteria belonging to strains of the Beijing family with different drug sensitivity (sensitive, multi and extensive drug-resistant) by surface-enhanced Raman spectroscopy (SERS) in the fingerprint region. The latter is focused on the spectral bands, which correspond to a set of glutathione bands and DNA methylation patterns revealed due to 5-methylcytosine spectral biomarkers. It is shown that these spectral features can be correlated with drug sensitivity and DNA methylation.
View Article and Find Full Text PDFQuantitative assessment of the generalizability of a brain tumor Raman spectroscopy machine learning model to various tumor types including astrocytoma and oligodendroglioma.
J Biomed Opt
January 2025
McGill University, Montreal Neurological Institute-Hospital, Montreal, Quebec, Canada.
Significance: Maximal safe resection of brain tumors can be performed by neurosurgeons through the use of accurate and practical guidance tools that provide real-time information during surgery. Current established adjuvant intraoperative technologies include neuronavigation guidance, intraoperative imaging (MRI and ultrasound), and 5-ALA for fluorescence-guided surgery.
Aim: We have developed intraoperative Raman spectroscopy as a real-time decision support system for neurosurgical guidance in brain tumors.
GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment.
Int J Oral Sci
January 2025
School of Cyber Science and Engineering, Sichuan University, Chengdu, China.
The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis.
View Article and Find Full Text PDFDeciphering the Ligand-Binding Site in a DNA Aptamer Targeting Deoxynivalenol.
Biochemistry (Mosc)
December 2024
Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia.
Food safety is one of the primary demands of modern society. Mycotoxins are toxic metabolites of food-contaminating fungi. Fungi enter the food chain by infecting crops and irreversibly contaminate them due to the structural stability of mycotoxins.
View Article and Find Full Text PDFDeep eutectic solvent induced silver-gel as a flexible SERS substrate for sensitive detection of antibiotics under low temperature conditions.
J Hazard Mater
January 2025
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi, 830017, Xinjiang, PR China; School of Materials Science and Engineering, Xinjiang Engineering Research Center of Environmental and Functional Materials, Xinjiang University, Urumqi, 830017, Xinjiang, PR China. Electronic address:
Antibiotic residues pose a significant threat to global health. Traditional detection methods for antibiotics are cumbersome, time-consuming and often incapable of achieving non-destructive detection at low temperatures. This research introduces a groundbreaking innovation in antibiotic detection: a flexible Surface-Enhanced Raman Scattering substrate based on a silver composite deep eutectic solvent (DES) gel, specifically engineered for low-temperature antibiotic detection.
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