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A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
Proc Natl Acad Sci U S A
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Key Laboratory of Molecular Nanostructure and Nanotechnology, Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine-protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely limiting its clinical effectiveness.
View Article and Find Full Text PDFA comprehensive review of recycling and reusing methods for plastic waste focusing Indian scenario.
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Department of Mechanical Engineering, Invertis University, Bareilly, Uttar Pradesh, India.
Plastics are integral to modern life but present significant environmental and economic challenges due to ineffective waste management systems. This article provides a comprehensive review of global plastic waste management (PWM) strategies, focusing on advancements in processing technologies, policy frameworks and their practical applications. It highlights the role of the World Intellectual Property Organization (WIPO) and regulatory bodies across the United States, Canada, Europe, Britain, India, Japan, Australia and China in fostering sustainable PWM practices.
View Article and Find Full Text PDFNontargeted Screening Nitrogen-Containing Organic Compounds in Frost and Wet Deposition in Rural Northeast China.
Environ Sci Technol
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Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Department of Environmental Science & Engineering, Fudan University, Shanghai 200438, China.
Nitrogen-containing organic compounds (NOCs) in frost serve as a critical pathway for atmospheric nitrogen deposition, significantly impacting the biogeochemical cycles of nitrogen. However, the molecular characteristics of NOCs in frost and their deposition fluxes are scarcely studied. In this work, frost samples, collected in rural Northeast China in the winter of 2023, were analyzed using nontargeted ultrahigh performance liquid chromatography-orbitrap mass spectrometry (UHPLC-Orbitrap MS) to reveal their content in nitrogen-containing organic compounds (NOCs) and explore their wet deposition fluxes.
View Article and Find Full Text PDFA systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS).
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Chemistry Matters, Calgary, Canada; Mount Royal University, Calgary, Canada.
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View Article and Find Full Text PDFStress signaling, response, and adaptive mechanisms in submerged macrophytes under PFASs and warming exposure.
Environ Pollut
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State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Heat stress disturbs cellular homeostasis and alters the fitness of individual organisms. However, it is unclear whether thermal perturbations exacerbate the toxic effects of per- and polyfluorinated alkyl substances (PFASs) on trophic endpoints in freshwater ecosystems. We conducted a mesocosm experiment to investigate the impact of warming and PFASs on the widespread submerged macrophytes (Hydrilla verticillata) at a molecular level.
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