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Biomarkers.
Alzheimers Dement
December 2024
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU, Munich, Germany.
Background: The myelin sheath around axons is of fundamental importance for signal transduction. Myelin is reduced in white matter hyperintensities (WMH), which occur in both small vessel disease (SVD) and Alzheimer's disease (AD), giving rise to the question to what extent myelin is reduced in these diseases. Here, we employed an advanced MRI based method to assess myelin independently from a major confounding factor, i.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Munich, Bavaria, Germany.
Background: The myelin sheath around axons is of fundamental importance for signal transduction. Myelin is reduced in white matter hyperintensities (WMH), which occur in both small vessel disease (SVD) and Alzheimer's disease (AD), giving rise to the question to what extent myelin is reduced in these diseases. Here, we employed an advanced MRI based method to assess myelin independently from a major confounding factor, i.
View Article and Find Full Text PDFConstruction and Magnetic Difference of {CoCoM} (M = Co/Cd) Aggregates with Homo- and Heterometallic Centers Derived from {Co} Precursors.
Inorg Chem
December 2024
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, PR China.
Controllable synthesis of sophisticated aggregations has attracted wide attention from scientists. In this work, homo- and heterometallic {CoCoM} ( = Co/Cd) aggregates with similar skeletons, composed of two [CoM(dpbt)] peripheries and a central [Co(OH)] vertex-fused double-cubane, were constructed from prefabricated {Co} clusters and characterized by single-crystal X-ray diffraction and XPS, ICP-MS, SEM (EDX), and so on. And then, the structure and magnetic differences of them had been further analyzed under dotted with paramagnetic Co ions and/or diamagnetic Cd ions.
View Article and Find Full Text PDFQuantitative susceptibility mapping with source separation in normal brain development of newborns.
AJNR Am J Neuroradiol
September 2024
From the Department of Radiology (M.J., A.V.D., Y.W., P.S., T.D.N., Z.Z.), Department of Pediatrics (Z.G.), and Department of Population Health Sciences (A.W., A.R.), Weill Cornell Medicine, New York, NY, USA; Institute for the Developing Brain (K.K., J.M., C.L.), Division of Diagnostic Imaging and Radiology, and Division of Fetal and Transitional Medicine (C.L.), Children's National Hospital, Washington, DC, USA; Department of Pediatrics (J.M., C.L.), and Department of Radiology (J.M., C.L.), School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Article Synopsis
- Scientists wanted to understand brain tissues in newborns by measuring myelin and iron using a new method called quantitative susceptibility mapping.
- They had 69 healthy newborns get MRI scans to see how these materials showed up in different parts of the brain.
- The results showed differences in brain signals: myelin had a lower signal in some areas while iron had a higher signal in others, helping to reveal how these substances are distributed in newborn brains.
Superconductivity in pressurized trilayer LaNiO single crystals.
Nature
July 2024
State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai, China.
The pursuit of discovering new high-temperature superconductors that diverge from the copper-based model has profound implications for explaining mechanisms behind superconductivity and may also enable new applications. Here our investigation shows that the application of pressure effectively suppresses the spin-charge order in trilayer nickelate LaNiO single crystals, leading to the emergence of superconductivity with a maximum critical temperature (T) of around 30 K at 69.0 GPa.
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