Our approach to the treatment of vestibular schwannomas with arachnoid dissection of the facial nerve.

Unlabelled: Preserving the function of the facial nerve is extremely important in surgery for vestibular schwannomas. Two methods of arachnoid dissection are described for resection of vestibular schwannoma via retrosigmoid approach (from the brain stem and internal auditory canal).

Objective: To evaluate the results of arachnoid dissection of the facial nerve from internal auditory canal when resecting the vestibular schwannoma.

[Surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele].

Background: In recent years, temporal lobe encephalocele has become more common in patients with focal drug-resistant epilepsy. Despite available experience, there are still no clear recommendations for choosing the extent of surgery in these patients.

Objective: To evaluate the effectiveness of diagnosis and surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele.

[Safety of robot-assisted implantation of deep electrodes for invasive stereo-EEG monitoring].

Unlabelled: Robot-assisted implantation of deep electrodes for stereo-EEG monitoring has become popular in recent years in patients with drug-resistant epilepsy. However, there are still few data on safety of this technique.

Objective: To assess the incidence of complications in patients with drug-resistant epilepsy undergoing robot-assisted implantation of stereo-EEG electrodes.

Necessity of fusion following decompression surgery in patients with single-level lumbar stenosis: study protocol for an open-label multicentre non-inferiority randomized controlled clinical trial.

Background: The necessity of spinal segment fusion after decompression is one of the most controversial and unresolved issues in single-level lumbar spinal stenosis surgery. To date, only one trial carried out 15 years ago focused on this problem. The key purpose of the current trial is to compare the long-term clinical results of the two surgical methods (decompression vs.

Opportunistic consumption of marine pelagic, terrestrial, and chemosynthetic organic matter by macrofauna on the Arctic shelf: a stable isotope approach.

Macrofauna can contribute substantially to the organic matter cycling on the seafloor, yet the role of terrestrial and chemosynthetic organic matter in the diets of microphagous (deposit and suspension) feeders is poorly understood. In the present study, we used stable isotopes of carbon and nitrogen to test the hypothesis that the terrestrial organic matter supplied with river runoff and local chemosynthetic production at methane seeps might be important organic matter sources for macrofaunal consumers on the Laptev Sea shelf. We sampled locations from three habitats with the presumed differences in organic matter supply: "Delta" with terrestrial inputs from the Lena River, "Background" on the northern part of the shelf with pelagic production as the main organic matter source, and "Seep" in the areas with detected methane seepage, where chemosynthetic production might be available.

Mapping the musician brain during awake craniotomy.

Direct cortical stimulation during awake craniotomy with speech testing became the «gold standard» in brain mapping and preserving speech zones during neurosurgical procedures. However, there are many other cerebral functions, and their loss can be very critical for certain patients. For example, such a function is production and perception of music for musicians.

[A tool to assess functional communication skills and its correspondence with traditional language testing in patients with brain tumors].

Objective: To identify the relationship between speech impairment as measured by the Russian Aphasia Test (RAT) and functional communication as assessed by the Communicative Effectiveness Index (CETI).

Material And Methods: RAT and CETI were administered to 87 patients at two time points, before surgery and in 3 months after brain tumor resection surgery.

Results: There were significant correlations between CETI and the total scores on RAT subtests for speech comprehension and production before surgery but not in the follow-up period.

Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy.

The placenta has a unique hypomethylated genome. Due to this feature of the placenta, there is a potential possibility of using regulatory elements derived from retroviruses and retrotransposons, which are suppressed by DNA methylation in the adult body. In addition, there is an abnormal increase in the level of methylation of the LINE-1 retrotransposon in the chorionic trophoblast in spontaneous abortions with both normal karyotype and aneuploidy on different chromosomes, which may be associated with impaired gene transcription using LINE-1 regulatory elements.

Revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Unlabelled: Nowadays, vertebral stenosis is the most common indication for surgical treatment in patients over 65 years old in spine surgery. According to the literature, there are conflicting data on the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Objective: To evaluate the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Surgical treatment of tumors of the supplementary motor area.

Unlabelled: After surgical treatment of tumors of the supplementary motor area (SMA) post-operative speech and/or motor neurological deficit may occur.

Objective: To determinate frequency and reversibility of such deficit and identify risk factors for its development.

Material And Methods: We retrospectively analyzed postoperative outcomes in 34 patients with SMA tumors.

Thermodynamics of Formation and Disordering of YBaCoO Double Perovskite as a Base for Novel Dense Ceramic Membrane Materials.

Differential scanning calorimetry studies of the complex oxide YBaCoO (YBC), combined with the literature data, allowed outlining the phase behavior of YBC depending on the oxygen content and temperature between 298 K and 773 K. The oxygen nonstoichiometry of single-phase tetragonal YBC was measured at different temperatures and oxygen partial pressures by both thermogravimetric and flow reactor methods. The defect structure of YBC was analyzed.

Mycorrhiza-feeding soil invertebrates in two coniferous forests traced with C labelling.

Mycorrhizal fungi represent a potentially abundant carbon resource for soil animals, but their role in soil food webs remains poorly understood. To detect taxa that are trophically linked to the extraradical mycelium of mycorrhizal fungi, we used stable isotope (C) labelling of whole trees in combination with the in-growth mesh bag technique in two coniferous forests. This allowed us to detect the flux of carbon in the mycelium of mycorrhizal fungi, and consequently in the tissues of soil invertebrates.

Nonstoichiometry, Defect Chemistry and Oxygen Transport in Fe-Doped Layered Double Perovskite Cobaltite PrBaCoFeO ( = 0-0.6) Membrane Materials.

Mixed conducting cobaltites PrBaCoFeO ( = 0-0.6) with a double perovskite structure are promising materials for ceramic semi-permeable membranes for oxygen separation and purification due to their fast oxygen exchange and diffusion capability. Here, we report the results of the detailed study of an interplay between the defect chemistry, oxygen nonstoichiometry and oxygen transport in these materials as a function of iron doping.

Modified posterior quadrant disconnection in surgical treatment of drug-resistant epilepsy in a patient with left temporal and occipital lobe malformation.

Unlabelled: Adults with large multilobar lesions of temporal, parietal and occipital lobes of the dominant hemisphere suffering from drug-resistant epilepsy were considered inoperable for a long time.

Objective: To demonstrate favorable postoperative outcome in a patient with massive periventricular heterotopia of the left temporal and occipital lobes complicated by drug-resistant epilepsy.

Material And Methods: We analyzed localization of the brain malformation (massive periventricular heterotopia) and its relationship with surrounding structures in a 38-year-old patient considering preoperative MRI, functional MRI and MR tractography data.

Benchmark of a functional-group database for distributed polarizability and dipole moment in biomolecules.

The extraction of functional-group properties in condensed phases is very useful for predicting material behaviors, including those of biomaterials. For this reason, computational approaches based on partitioning schemes have been developed aiming at rapidly and accurately estimating properties from chemically meaningful building blocks. A comprehensive database of group polarizabilities and dipole moments is useful not only to predict the optical properties of biomacromolecules but also to improve molecular force fields focused on simulating biochemical processes.

Biosimilar erythropoietin in anemia treatment (BEAT)-Efficacy and safety of a 1:1 dose conversion from EPREX® to EPIAO® in patients with end-stage renal disease on hemodialysis: A prospective, randomized, double blind, parallel group study.

Background: EPREX®/ERYPO®/PROCRIT® (epoetin alfa, Janssen-Cilag GmbH) was the first available recombinant human erythropoietin (rHuEPO) and was universally reference product as per the recommendation provided by European Medicines Agency. EPIAO® is a biosimilar formulation of EPREX®, and making it a 1:1 dose conversion from EPREX® according to recommendation of European Medicines Agency. This study evaluated the clinical efficacy and safety of EPIAO® in subjects with end-stage renal disease receiving hemodialysis after intravenous administration.

Thermochemical Study of CHNHPb(ClBr) Solid Solutions.

Hybrid organic-inorganic perovskite halides, and, in particular, their mixed halide solid solutions, belong to a broad class of materials which appear promising for a wide range of potential applications in various optoelectronic devices. However, these materials are notorious for their stability issues, including their sensitivity to atmospheric oxygen and moisture as well as phase separation under illumination. The thermodynamic properties, such as enthalpy, entropy, and Gibbs free energy of mixing, of perovskite halide solid solutions are strongly required to shed some light on their stability.

Surgical treatment of glial tumors of the paralimbic system.

Background: Tumors of the paralimbic system were considered inoperable for a long time due to high risk of postoperative complications. However, there have been significant changes in surgical tactics for these neoplasms over the past decades. Despite the improvement of surgical principles for these tumors and development of new approaches, risks of surgical treatment are still high (up to 33.

Epileptogenic high-frequency oscillations present larger amplitude both in mesial temporal and neocortical regions.

High-frequency oscillations (HFO) are a promising biomarker for the identification of epileptogenic tissue. While HFO rates have been shown to predict seizure outcome, it is not yet clear whether their morphological features might improve this prediction. We validated HFO rates against seizure outcome and delineated the distribution of HFO morphological features.

[Intraoperative ultrasound-assisted surgery of spinal tumors].

Objective: To improve technique of intraoperative ultrasound-assisted microsurgery of spinal tumors.

Material And Methods: There were 68 patients with 70 spinal tumors who underwent intraoperative ultrasound-assisted resection between 2007 and 2018. Age of patients varied from 21 to 80 (mean 48.

Fault Identification in Electric Servo Actuators of Robot Manipulators Described by Nonstationary Nonlinear Dynamic Models Using Sliding Mode Observers.

The problem of fault identification in electric servo actuators of robot manipulators described by nonstationary nonlinear dynamic models under disturbances is considered. To solve the problem, sliding mode observers are used. The suggested approach is based on the reduced order model of the original system having different sensitivity to faults and disturbances.

Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors.

BH3 mimetics represent a promising tool in cancer treatment. Recently, the drugs targeting the Mcl-1 protein progressed into clinical trials, and numerous studies are focused on the investigation of their activity in various preclinical models. We investigated two BH3 mimetics to Mcl-1, A1210477 and S63845, and found their different efficacies in on-target doses, despite the fact that both agents interacted with the target.

Development of Medical Sensor Systems in Pulmonology Based on Electrical Impedance Measurement.

In order to experimentally confirm the dependence of the bioelectrical impedance on the flow rate of charged aerosol particles and the composition of bronchial secretions in small airways, the electrical impedance of an aerosol of 0.9% NaCl solution in polyethylene tubes of various diameters was studied. The electrical impedance was also measured in cylindrical chambers of various diameters and volumes filled with a 0.