High CD38 expression defines a mitochondrial function-adapted CD8 T cell subset with implications for lung cancer immunotherapy.

Despite identifying specific CD8 T cell subsets associated with immunotherapy resistance, the molecular pathways driving this process remain elusive. Given the potential role of CD38 in regulating CD8 T cell function, we aimed to investigate the accumulation of CD38CD8 T cells in lung cancer and explore its role in immunotherapy resistance. Phenotypic analysis of tumoral CD8 T cells from both lung cancer patients and immunotherapy-resistant preclinical models revealed that CD38-expressing CD8 T cells consist of CD38 and CD38 subsets.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Ultra-stretchable, self-recoverable, notch-insensitive, self-healable and adhesive hydrogel enabled by synergetic hydrogen and dipole-dipole crosslinking.

Hydrogels are promising materials for wearable electronics, artificial skins and biomedical engineering, but their limited stretchability, self-recovery and crack resistance restrict their performance in demanding applications. Despite efforts to enhance these properties using micelle cross-links, nanofillers and dynamic interactions, it remains a challenge to fabricate hydrogels that combine high stretchability, self-healing and strong adhesion. Herein, we report a novel hydrogel synthesized the copolymerization of acrylamide (AM), maleic acid (MA) and acrylonitrile (AN), designed to address these limitations.

E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure.

Objective: Heart failure (HF) causes structural and functional changes in the heart, with the pyroptosis-mediated inflammatory response as the core link in HF pathogenesis. E3 ubiquitin ligases participate in cardiovascular disease progression. Here, we explored the underlying molecular mechanisms of E3 ubiquitin ligase Smurf1 in governing HF.

Traditional Chinese medicine strategies to optimize antibiotic use and reduce the burden of antibiotic resistance in Chinese children.

Antibiotic resistance is one of the greatest threats to human health, especially children's health. Traditional Chinese medicine encompasses several documented treatments for pediatric infectious diseases. The antibacterial efficacy and potential of traditional Chinese medicine to reverse bacterial resistance are gaining increasing research attention.

Imaging biomarker associated with early neurological deterioration in isolated pontine infarction.

Objective: To investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.

Methods: 107 patients with acute isolated pontine infarcts, within 24 h of symptom onset, were retrospectively analyzed. The mean age of the participants was 67 years.

Comparison of a Series of Ga-Labeled DOTA-LLP2A Conjugates for Positron Emission Tomography Imaging of Very Late Antigen-4 in Melanoma.

Melanoma, with its steadily rising global incidence, is characterized by high invasiveness, leading to poor prognosis in advanced stages. There remains an unmet clinical need for the development of radiolabeled PET imaging probes for the early diagnosis of melanoma. Integrin VLA-4, a key factor in melanoma metastasis, presents a promising protein target to address the specificity shortcomings of existing probes in melanoma imaging.

Ultrasonography, contrast-enhanced ultrasonography and contrast-enhanced computer tomography features of hepatic sarcomatoid carcinoma and hepatic sarcoma: a retrospective study of 23 cases.

Background: Hepatic sarcomatoid carcinoma (HSC) and hepatic sarcoma (HS) are rare malignancies. Without pathology, the differential diagnosis between these two tumors is difficult due to their frequent overlaps in clinical presentations and imaging features. Currently, there are limited analyses about the ultrasound (US), contrast-enhanced ultrasound (CEUS) and contrast-enhanced computer tomography (CECT) characteristics of HSC and HS.

Exploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA.

Background: Submergence stress is a prevalent abiotic stress affecting plant growth and development and can restrict plant cultivation in areas prone to flooding. Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. Red clover (Trifolium pratense L.

Chlamydia psittaci pneumonia - evolutionary aspects on chest CT.

Purpose: To present the different findings of Chlamydia psittaci (C. psittaci) pneumonia on computed tomography (CT) according to the progression of the disease, to improve diagnostic accuracy, guide early clinical diagnosis, evaluate treatment efficacy, and reduce the mortality associated with the disease.

Methods: In total, 80 cases of C.

Assessing habitat selection parameters of Arabica coffee using BWM and BCM methods based on GIS.

Arabica coffee, as one of the world's three native coffee species, requires rational planning for its growing areas to ensure ecological and sustainable agricultural development. This study aims to establish a decision-making framework using Geographic Information Systems (GIS) and Multi-Criteria Decision-Making (MCDM), with a focus on assessing the habitat suitability of Arabica coffee in Yunnan Province, China. The impacts of climate, topography, soil, and socio-economic factors were considered by selecting 13 criteria through correlation analysis.

Evaluation of postoperative drainage necessity in posterior atlantoaxial fixation via intermuscular approach for odontoid fracture.

The necessity of routinely placing closed suction wound drainage in spinal surgery has been questioned. This study aims to assess if closed suction wound drainage is necessary for posterior atlantoaxial fixation via intermuscular approach. The functional outcomes of these 40 patients who underwent posterior atlantoaxial fixation via intermuscular approach without drainage tube (Group A) were compared with that of a control group, which consisted of 68 randomly enrolled cases with posterior atlantoaxial fixation via intermuscular approach with drainage tube (Group B).

Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy.

Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). In this study, we report the design guidelines towards efficient Type-I semiconducting polymer photosensitizer and modify the best-performing polymer into a hypoxia-tolerant polymeric photosensitizer prodrug (HTPS) for cancer photo-immunotherapy. HTPS not only performs Type-I PDT process to partially overcome the limitation of hypoxic tumors in PDT by recycling oxygen but also specifically releases a Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor (Niclosamide) in response to a cancer biomarker in the TME.

The giant genome of lily provides insights into the hybridization of cultivated lilies.

Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts. Here, we present reference genomes for Lilium sargentiae (lily, 35.

Crystal structure of Au-pseudocarbyne(C).

Carbyne-related materials permit exploring the potentially extraordinary properties of this long-sought but still elusive carbon allotrope. However, accurate understanding of these materials is challenging. Here we report the crystal structure of a Au-pseudocarbyne, a representative of a possible new family of materials consisting of sp-hybridized carbon chains and stabilizing metal atoms.

A synthetic methylotroph achieves accelerated cell growth by alleviating transcription-replication conflicts.

Microbial utilization of methanol for valorization is an effective way to advance green bio-manufacturing technology. Although synthetic methylotrophs have been developed, strategies to enhance their cell growth rate and internal regulatory mechanism remain underexplored. In this study, we design a synthetic methanol assimilation (SMA) pathway containing only six enzymes linked to central carbon metabolism, which does not require energy and carbon emissions.

A new-to-nature photosynthesis system enhances utilization of one-carbon substrates in Escherichia coli.

Photosynthesis harvests solar energy to convert CO into chemicals, offering a potential solution to reduce atmospheric CO. However, integrating photosynthesis into non-photosynthetic microbes to utilize one-carbon substrates is challenging. Here, a photosynthesis system is reconstructed in E.

Asynchronicity of deglacial permafrost thawing controlled by millennial-scale climate variability.

Permafrost is a potentially important source of deglacial carbon release alongside deep-sea carbon outgassing. However, limited proxies have restricted our understanding in circumarctic regions and the last deglaciation. Tibetan Plateau (TP), the Earth's largest low-latitude and alpine permafrost region, remains underexplored.

Versatile parallel signal processing with a scalable silicon photonic chip.

Silicon photonic signal processors promise a new generation of signal processing hardware with significant advancements in processing bandwidth, low power consumption, and minimal latency. Programmable silicon photonic signal processors, facilitated by tuning elements, can reduce hardware development cycles and costs. However, traditional programmable photonic signal processors based on optical switches face scalability and performance challenges due to control complexity and transmission losses.

Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.

Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients' quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their orderly termination. In this study, we present a spatially confined conduit strategy, designed to enhance the self-organization of regenerating nerves after truncation.

Living plastics from plasticizer-assisted thermal molding of silk protein.

The pursuit of materials, particularly plastics, with a minimal ecological footprint throughout their circular lifecycle, is crucial for advancing sustainable materials development. Living materials composed of embedded yet active organisms can leverage endogenous biotic resources to achieve functional materials that align with sustainability goals. However, current living material systems face challenges such as weak mechanical properties, limited environmental adaptability, and restricted cellular functionality.