Visualization of 2D and 3D Tissue Models via Size-Selected Aqueous AgInS/ZnS Quantum Dots.

Three-dimensional (3D) spheroid cell cultures of fibroblast (L929) and tumor mammary mouse (4T1) were chosen as in vitro tissue models for tissue imaging of ternary AgInS/ZnS fraction quantum dots (QDs). We showed that the tissue-mimetic morphology of cell spheroids through well-developed cell-cell and cell-matrix interactions and distinct diffusion/transport characteristics makes it possible to predict the effect of ternary AgInS/ZnS fraction QDs on the vital activity of cells while simultaneously comparing with classical two-dimensional (2D) cell cultures. The AgInS/ZnS fractions, emitting in a wide spectral range from 635 to 535 nm with a mean size from ∼3.

Luminescent Composite Carbon/SiO Structures: Synthesis and Applications.

Luminescent carbon nanostructures (CNSs) have attracted great interest from the scientific community due to their photoluminescent properties, structural features, low toxicity, and a great variety of possible applications. Unfortunately, a few problems hinder their further development. These include the difficulties of separating a mixture of nanostructures after synthesis and the dependence of their properties on the environment and the aggregate state.

Photoluminescence-based immunochemical methods for determination of C-reactive protein and procalcitonin.

Modern, sensitive, rapid, and selective analytical methods for the detection of inflammatory markers are a crucial tool for the assessment of inflammation state, efficacy of medical intervention, and the prediction of future diseases. Their development requires understanding of current state for point-of-care testing of inflammatory markers and identification of their crucial drawbacks. This review summarizes the progress in the application of luminescent labels for immunoassays.