[Mechanisms of antioedemic effect of bioflavonoids in experiment].

In treatment of various-aetiology chronic oedemas, of great importance is a possibility of exerting an influence on the resorptional, transportation and transmission functions of the lymphatic system, as well as on the microcirculatory blood channel, because they all maintain the balance of fluid exchange in tissues. There exist various causes of chronic oedema, which requires a differentiated approach to administration of bioflavonoids possessing different mechanisms of antioedemic action. With this in mind we carried out experimental histomorphometric studies on 24 rats, aimed at determining variously directed effects of agents belonging to the class of bioflavonoids - phlebodia 600 (diosmin) and troxerutin on regeneration ability of the lymphatic endothelium and permeability of blood capillaries.

[Cellular changes in the paraurethral zone of the experimental animals in exposure to collost gel].

An experimental trial of the collagen gel collost was made on Wistar white female rats aged 68 and 30-36 months. 7 and 15% collost gel (the first Russian collagen gel produced from cattle skin) was implanted in paraurethral region of the animals. The connective tissue cells in the zone of collost gel injection was studied histologically, immunohistochemically, electron microscopically.

[The use of exogenous nitrogen monoxide for the prophylaxis of postoperative wound infection].

The study covers treatment results of 220 patients operated on ventral hernia and in vivo experimental treatment of 36 rats proved the nitrogen monoxide (NO) to be the effective means of wound infection prophylaxis. NO potentiates antiseptic effects, minimizing intraoperative wound contamination. It, besides, stimulates endothelial and basal cells of epidermis proliferation.

[Effect of dinitrosyl iron complexes with thiol-containing ligands on the penile cavernosum bodies in rats].

A beneficial effect of dinitrosyl iron complexes (DNIC) with thiol-containing ligands on penile cavernus tissue was shown in rats subjected to penile denervation. Histological and histochemical investigations demonstrated that intracavernous injections of dinitrosyl iron complexes (2 times per one week during 6 months) blocked the reinforcement of endothelial cell proliferation in the tissue characteristic of the cavernous tissue when the penile nerve was removed. On the other hand, treatment with dinitrosyl iron complexes led to the preservation of mitotic activity of smooth myocytes and protected against the appearance in these cells of collagenase, an indicator of muscle transformation into fibrous tissue.

[Serotonin level in endocrine cells in bronchial mucosa and stomach in chronic obstructive lung diseases].

85 patients aged 26-60 years with pulmonary chronic obstructive diseases (PCOD) and gastric and duodenal erosive-ulcerous lesions were investigated. In PCOD the increased bioamines level in endocrine cells of bronchial ciliated epithelium and gastric glandular epithelium was detected before the treatment. The complex treatment in the form of bronchoscopy with lymphotropic administration of antibiotic and immunomodulator against the background of intragastral ozonotherapy contributes to the decrease in tissue edema, restoration of their trophicity and inflammatory process resolution.

[Intratracheal lymphotropic ozone therapy in erosive-ulcerous tracheitis].

Under observation there were 452 patients with chronic stenosis of hollow organs of the neck having cannulas during the period from 3 months to several years. During the tracheobronchoscopic examination it was found that 35 patients had trachea ulcers, 46 patients had erosive tracheobronchitis. The ulcers were localized on the anterior wall of the thoracic part of the trachea.

[Method of medicamentous saturation of lymphatic system].

Data of experimental study in 18 mongrel dogs followed by clinical trial in 96 patients are represented, which concerns a method of indirect medicamentous saturation of lymphatic system, consisted in creation of medicamentous subcutaneous infiltration in the thighs followed by pneumocompression. Gentamycin contents in blood lymphatics and organs of experimental animals was studied in various periods of time. The obtained data have determined identity of the effect with the method of introduction of the antibiotics together with the media, which possess hyaluronidaze-like action, and followed by 2 hours duration phlebohypertension (by V.

[Prophylaxis of purulent complications in operations on large joints by endolymphatic infusion of drugs].

2 groups of patients operated on knee joints for traumatic injuries were examined. In the study group endolymphatic drug therapy was carried out in postoperative period, in control group of patients conventional way of intramuscular administration of preparations was used. During the treatment, plasmatic cells, macrophages and tissue basophiles in synovial liquor were studied as well as synthesis of nucleic acids (DNA and RNA) in plasmatic cells.

[Lymph dilution as a method of treatment in endotoxicosis].

Lymph dilution was used in 26 females with inflammation of the uterine appendages and 22 patients with appendicular infiltrate. 500 ml of sodium chloride solution with gentamycin (1.4 mg/kg) were dripped in the subcutaneous fat of the femur anterior surface.

[The valvular apparatus and tissue organization of the endothelium of the thoracic duct].

The structure of ostial valves and valves located along the thoracic duct and of its branches ostial valves and right lymphatic duct ostial valves were studied in 30 experimental outbred dogs and 46 cats. Cryodestruction of thoracic duct was performed in 28 outbred cats. 1, 3, 7 and 14 days later perfusive fixation with intercellular borders impregnation was carried out with simultaneous examination of intact regions of intravalvular segments, cisterna chyli and area of thoracic duct trunks connection with valvular surfaces.

[The vascular microrelief of the blood and lymph microcirculatory beds of the heart].

Peculiarities of topography and stereometry of the heart hemomicrocirculatory bed were studied by method of scanning electron microscopy of corrosive preparations. Different links of the heart hemomicrocirculatory bed were found to have expressed morphological signs, revealed distinctively by the methods named. This allows to differentiate them and to carry out an analysis of their functional peculiarities.

[The cardiac microcirculatory bed based on data from the scanning electron microscopy of corrosion preparations].

The method of scanning electron microscopy of cast preparations was used to study the volumetric interrelations of hemo- and lymph microcirculation bed links as well as specific features of the relief of the wall of the heart vessels in question. The lymphangions were confirmed to be rightfully considered as a morphological unit of the lymph microcirculation bed. The valve-shaped impressions and folds of the relief of a cast of lymph capillaries and postcapillaries were found which shows the ability of the lymph postcapillaries to maintain a one-direction flow of lymph and to change the lumen width for different amounts of the flowing lymph.

[The lymphatic system of the lower extremities in patients with obliterating diseases of the terminal portion of the aorta and its branches].

The paper deals with the results of X-ray lymphographic and morphological studies of the peripheral lymphatic system in 82 patients with various stages of chronic lower extremity arterial insufficiency. Destructive and sclerotic changes in lymphatic vessels, inguinal lymph nodes, and impairments in lymph flow whose severity was in proportion to the stage of chronic ischemia were detected. The associated immune, barrier-filtration and transport dysfunctions called for their adequate correction.

[Primary controlled endolymphatic antibiotic therapy in traumatology and orthopedics].

The work analyses 55 cases of traumatic osteomyelitis of the leg bones, open fractures of the leg bones, and medial fractures of the femoral neck. Patients with medial fractures of the neck of the femur were treated by endoprosthesis after Mur-Kaplan. Endolymphatic antibiotic therapy was included in the complex of therapeutic measures in each group of patients.

[Study of the lympho- and hemomicrocirculatory bed of lymph nodes by scanning electron microscopy].

The spatial interrelation of the lymphatic and blood beds has been studied in the lymph node together with its stromal and lymphoid elements, using scanning electron microscopy of corrosive casts and native preparations. There is a great variety of pathways for lymph transport and blood vessels in dependence of their localization in the lymph node. Of a special interest are the pathways of lymphocytes migration across the walls in the cortical and medullary sinuses and in the postcapillary venules, as well as participation of the reticular tissue in the lymph node immune reactions.

[Morphofunctional changes in the lymph nodes and microcirculatory bed of small-intestinal mesentery of dogs in septic peritonitis after endolymphatic administration of ampicillin].

With the aim to study effectiveness+ of endolymphatic (EL) administration of ampicillin (AC), using the model of an acute diffuse septic peritonitis in dogs, the morphological and morphometrical investigation has been performed concerning the state of the lymph nodes (LN), which are regional as regards the pathological focus (pelvic) and remote (tracheobronchial, mesenteric) and hemomicrocirculatory bed (HMCB) of the small intestine mesentery. All LN groups studied are involved in the pathological process, that produces certain increasing disturbances in the structure and cell composition in LN. In 6 h the changes are especially manifested in the pelvic LN, and in 18 h--in the animals without application of AC, or at its intramuscular injection LN lose their typical structure.

[Microrelief of the internal surface of the thoracic duct in dogs (based on scanning electron microscopy data)].

The investigation has been performed on 17 mature dogs. With the aim to investigate the internal surface of the thoracic duct, the methods of scanning electron microscopy of native, impregnated and corrosive preparations have been used. The analysis of the scannograms obtained demonstrates that the valves of the thoracic ducts are mainly bicuspid, have a typical infundibular form, their cuspides are fused, forming a mesentery-like fold on the duct wall.

[The microcirculatory bed of the human heart].

Using a complex approach in studying microcirculatory bed of the human heart, possibilities of scanning electron microscopy of corrosive preparations, those of silver nitrate impregnation after V. V. Kuprianov are demonstrated.

[Principles of organization of tissue mosaics of simple squamous epithelia].

With the aim to study general principles on organization of tissue mosaics of various types of simple squamous epithelii, a quantitative topological analysis has been performed in the frog mesothelial mosaics, in the posterior epithelium of the rabbit cornea and in the rat aortal endothelium after Lewis method. To all the types of simple squamous epithelii studied the histological law of Lewis can be applied. As demonstrates the qualitative analysis of the mosaics, the mesothelium and the posterior epithelium of the cornea are typical isotropic mosaics, while the mosaic of the aortal endothelium is nearer to the polystichous one.

[Hydrolysis of streptococcal polysaccharides by micromycete dextranases].

The effect of dextranase enzyme preparations obtained from Penicillium piscarium BIM G-102, Penicillium funiculosum, Aspergillus insuetus G-116 and Aspergillus ustus on polysaccharides synthesized by cariesogenic Streptococcus sanguis and Streptococcus mitis was being studied. According to the data obtained dextranases from P. piscarium, P.