[Changes in the morphological characteristics of the endodontic system and parameters of human dental hard tissues in the North-Western region of Siberia during the X-XX centuries].

The Aim Of The Study: Was a comparative analysis of the structural features of the endodontic system and the thickness of hard dental tissues over the past ten centuries.

Materials And Methods: 180 teeth of people who lived from the X to XX centuries AD were studied using cone-beam computed tomography in endodontic mode: the volume of the endodontic system and the thickness of hard dental tissues were calculated using the algorithm developed by us. The Pearson correlation coefficient and Student's t-test were calculated in Excel program, and the data was analyzed with GraphPad Prism 8 Statistics Guide statistical program.

Point-of-care ultrasonography in Ukraine: a survey of anesthesiologists-intensivists participating in ultrasonography courses.

Purpose: Despite the potential value of point-of-care ultrasonography (POCUS) in resource-limited environments, it is not widely used in low- and middle-income countries compared with high-income countries. We sought to evaluate the current POCUS practice of Ukrainian anesthesiologists who attended POCUS courses to guide future POCUS training in Ukraine.

Methods: We conducted a 25-question web-based survey.

attachment-blocking antibodies protect against duodenal ulcer disease.

The majority of the world population carry the gastric pathogen . Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of carriers.

Toluidine blue for the detection of sentinel lymph nodes in patients with thyroid cancer.

Introduction: Thyroid cancer (TC) demonstrates steady growth in incidence worldwide and remains an urgent problem in oncology. The detection of sentinel lymph nodes (SLN) with a selective dye and further histological examination in selecting the proper (personalized) surgical strategy and the volume of surgical intervention for clinically undetermined regional lymph nodes. The purpose of the study is to evaluate the effectiveness and safety of intraoperative detection of SLN with a 1% toluidine blue aqueous solution.

Pervasiveness of HLA allele-specific expression loss across tumor types.

Background: Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing of cancer cells. According to recent reports, patient HLA-I genotypes can impact the efficacy of cancer immunotherapy, and the somatic loss of HLA-I heterozygosity has been established as a factor in immune evasion. While global deregulated expression of HLA-I has also been reported in different tumor types, the role of HLA-I allele-specific expression loss - that is, the preferential RNA expression loss of specific HLA-I alleles - has not been fully characterized in cancer.