Publications by authors named "m A Dzhangidze"

The effect of hormonal contraception on cervix of the uterus of young nullipara women with ectopia was investigated. Cohort study was carried out by using simple blind method. By means of statistical data manipulation correlation between the application of hormonal contraceptives and changes of colposcopy pictures in the zone of pathology was displayed.

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We have studied the relationship between the hypoxic change and mitochondrial redox-potential disturbances in the mechanism of pheto-placental insufficiency in pregnancy with cytomegalovirus infection (CMV), detected by the positive anti-CMV-IgG titer and more then 4-fold increase of low avid anti-CMV-IgG. It was shown, that chronic CMV infection induces production of active forms of oxygen, peroxidation of structures and concurrently damage of mitochondria with essential decrease of ATP level. Results of the study have shown the important diagnostic value of estimation of hypoxic-oxidative damage induced by CMV infection.

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An early initiation of sexual life as the cause of problem concerning hormonal contraception with young women not given birth acquires a special actuality. It is known that no matter how carefully the operation of abortion is held, it is inevitably accompanied by the traumatization of cervix, especially in women with first pregnancy. According to the reference data the consequences of the first abortion in every third woman are the inflammatory diseases of reproductive organs, the infringement of menstruation, infertility, ectopic pregnancy, endometriosis, etc.

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A new method of treatment of endometriosis includes combination of surgical and hormonal therapy. Surgical method included excision of tissue with endometriosis, while the hormonal therapy involved the combination of dufaston and reaferon-EC (recombinant interferon alpha 2b). The aim of this study was to develop effective method of treatment of infertility caused by endometriosis using combination of dufaston and reaferon.

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