[Therapeutic effects of medical rehabilitation in patients suffered from coronary heart disease with lower limb amputation].

Unlabelled: Disabled persons, who have undergone lower limb amputation (LLA) due to obliterating atherosclerosis, are a special group among patients with coronary heart disease (CHD). In the developed countries, 25-35% of patients was performed high LLA in the first year of critical ischemia, ant the number of interventions is steadily increasing. The development of personalized medical rehabilitation programs (MR) for such patients is relevant.

[Clothing and footwear for the elderly and senile: recommendations for the formation of a special wardrobe.].

According to WHO, the number of elderly and senile people by 2050 will amount to more than 2 billion people. The period 2020-2030 is designated by WHO as the «Decade of Healthy Aging» with a program according to which healthy aging is designed to delay the dependence of this age group on outside help, to promote their long healthy life. Such a statement of the problem indicates an understanding of the relevance of the development of functionally comfortable and aesthetically designed clothing and footwear designs that provide this contingent with independence in self-service and contribute to their successful longevity.

Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation.

A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins.

[Rheumatic polymyalgia is a rarely diagnosed, but often occurring disease in elderly patients.].

Verification of the diagnosis of rheumatic polymyalgia at the reception of a general practitioner, geriatrician presents significant difficulties due to the lack of pathognomonic signs of the disease. The «calling card» of the disease is a combination of severe pain in the proximal muscle groups in combination with a high acute inflammatory response.

[The influence of hearing and vestibular impairments on cognitive function in elderly people.].

Cognitive function is a complex brain function that is important in the cognition of the reality and connecting with it. It has a complicated reflex basis, arises from external factors exposure, improves by growing up and learning till its maximum and declines in the elderly age. For several years it was believed that cognitive function drop is connected with ageing processes of the whole organism.

[Current issues of disability and rehabilitation of elderly and senile patients with lower limb loss due to vascular pathology.].

The majority of patients with amputation defect of the lower extremities are elderly citizens with high co- and polymorbidity, the presence of several geriatric syndromes, which adversely affects the prognosis, reduces the rehabilitation potential, in some cases leads to the development of cardiovascular complications, amputation of the second limb, severe disability and high postoperative mortality. The key link in the rehabilitation process of disabled people with a lower limb stump is to provide them with a functional prosthesis. The article provides an analysis of morbidity, primary disability in the period from 2015 to 2019, gender, age and clinical characteristics of patients living in St.

[Legal Regulation of Hospital-Substituting Aspects of Social Services for Elderly and Disabled Citizens at Home.].

The article presents information about a significant number of people older than working age, disabled people and recipients of social services in stationary form and about the unfavorable forecast of the number of people older than 65 years for 2024 and 2030 in the Russian Federation, which determines the need for legal regulation of their lifestyle issues with respect for human rights to lead an independent lifestyle. The authors present an analysis of the federal and regional legal framework in terms of determining the circumstances under which a citizen is recognized as needing social services, the participation of local self-government bodies and subordinate organizations in the provision of social services, the implementation of social support, the introduction of hospital-substituting social service technologies. The article discusses the trends and ways to improve the legal regulation of social services for elderly and disabled citizens at home from the perspective of the introduction of hospital-substituting elements.

[Assessment of barriers in people with disabilities with ophthalmopathology and varying degrees of sensory impairment to substantiate the list of support services they need and social protection measures in different areas of life.].

The assessment of barriers in persons older than working age with visual impairment was carried out using the International Classification of Functioning, Disabilities and Health to substantiate the list of necessary support services. An increase in the absolute number of people in older age groups objectively leads to an increase in the number of citizens experiencing difficulties in solving medical, social and psychological problems. Analysis of the results of the study showed that a significant part of people, due to impaired visual functions, experience limitations and barriers in physical environment, emotional sphere, family relationships with close and distant relatives.

[Nordic walking in an integrated approach to improving the quality of life of the elderly.].

The article analyzes the results of the impact of an integrated approach to lifestyle modification, including Nordic walking, rational nutrition and pharmacotherapy, on the quality of life of elderly people (average age 72,5±3,6 years). A significant improvement in the pain scale indicator of the MOS SF-36 was revealed after six months (p=0,001), which was also determined by the end of the year (p=0,0001). A tendency to improve the quality of life was revealed in the Minnesota Questionnaire after six months (p=0,0617).

[Age-related specifics or diseases and disability caused by digestive disorders among adults in Saint-Petersburg in 2013-2017.].

The paper presents the retrospective analysis of the structure and dynamics of diseases and disability caused by digestive disorders in Saint Petersburg citizens. The paper presents the results of the comparative analysis of disability among people of active working and pension ages living in Saint Petersburg, versus Russia's average 2013-2018 data. As a result, regularities and differences in the structure and dynamics of digestive disorders in people 18 years old and older, which manifested themselves in after-surgery complications, death rate, and disability rate.

[Influence of hearing decline on cognitive function in elderly and senier age patients and its assessment after cochlear implantation (literature review).].

The study of the effect of cochlear implantation on cognitive function is an urgent problem, since the world is increasing the population of elderly and senile people who, as a rule, have certain hearing impairments. Age-related hearing loss is one of the most common health problems associated with aging, affecting two-thirds of people over the age of 70. However, few adults are tested for hearing loss, and even fewer are being treated.

[Evaluation of the effectiveness of rehabilitation of elderly patients with metabolic syndrome, taking into account the provisions of International classification of functioning, disability and health.].

The article contains data on rehabilitation measures in elderly patients with metabolic syndrome. Individual-oriented treatment and rehabilitation programs implemented in primary health care allow to reliably reduce the severity and risk of progression of restrictions of life, increase the independence of patients The elderly, having metabolic syndrome, complicated the development of type 2 diabetes mellitus. It is proposed to assess the effectiveness of rehabilitation, taking into account the provisions of the International Classification of functioning, restrictions on life and health and by drawing up an individual geriatric profile.

[Dynamics and structure of primary disability in persons of retirement age when applying to the Bureau of Medical and Social Expertise of Saint Petersburg from 2006 to 2017.].

The article presents data on primary disability in elderly and able-bodied people and older than able-bodied (retirement) age as a result of the survey of citizens in the Bureau of Medical and Social Expertise of Saint Petersburg in the period 2006-2017. The features of the level, structure, dynamics and distribution by groups of disability in retirement age are reflected. There was a significant increase in the level of disability in 2007, with a progressive decline to 2011 and a gradual decline until 2017.

[Clinical and experimental study of the peculiarities of cardiac activity disorders during poisoning by combustion products in persons of different age groups.].

The work is carried out to clarify the mechanisms of cardiac activity disorders and assess the severity of cardiotoxicity in acute poisoning by combustion products in the age aspect. 71 patients with severe carbon monoxide poisoning were examined. The comparison group consisted of 22 patients with acute severe opiate poisoning.

[THE DYNAMICS AND STRUCTURE OF INDICATORS OF SECONDARY DISABILITY DUE TO CEREBROVASCULAR DISEASES IN THE ELDERLY IN ST. PETERSBURG IN THE PERIOD 2005-2014].

The article presents data about secondary disability due to cerebrovascular diseases in the elderly based on results of examination in the Bureau of medical-social expertise of Saint Petersburg in the period from 2005 to 2014. Тhe analysis revealed a high proportion of the disabled elderly in the structure of disability due cerebrovascular diseases; and the growth of the share of people with disabilities elderly in the analyzed period.

[Analysis of indicators of primary disability due to cerebrovascular diseases in people of retirement age according to the results of medical and social examination in St. Petersburg].

The article presents data on the primary disability due to cerebrovascular disease in elderly patients based on the results of the survey in the Bureau of Medical and Social Expertise of Saint-Petersburg from 2005 to 2014. The analysis showed a reduction in the indicators of primary disability due to cerebrovascular disease and the increase in the share of persons with disabilities of the first and third groups in its structure.

[Evaluation of the clinical, psychological and socio-environmental factors, affecting disability of elderly people undergoing surgical myocardial revascularization].

Factors significant for clinical-and-labor prognosis in elderly patients with ischemic heart disease after surgical myocardial revascularization are considered in the article. The authors demonstrate that for each level of the problem there are their own significant factors. Besides, the most essential correlations between investigated factors are marked out.

[Factors significant for clinical-and-labor prognosis in elderly patients with ischemic heart disease after surgical myocardial revascularization].

Factors significant for clinical-and-labor prognosis in elderly patients with ischemic heart disease after surgical myocardial revascularization are considered. It is demonstrated that each level of the problem in consideration has its own significant factors. Besides, the most essential correlations between investigated factors are marked out.

[Assessment of effectiveness of ischemic heart disease rehabilitation of elderly patients using six-minutes walking test].

The possibility to use the test with a six-minute walk to assess the effectiveness of long-term programs of rehabilitation, definite disability and severity of heart failure in middle-aged and elderly patients with coronary heart disease is discussed.

[Features of age-related changes of the heart in determining the limits of life of patients with diabetes mellitus].

Detailed data on age-related changes of the heart in patients with diabetes are stated. The data of expertise rehabilitation diagnostics of diabetic cardiomiopathia in invalids on the basis of inspection of 152 patients with diabetes are provided.

[Analysis of disability resulting from cardiovascular disease patients of retirement age uptake bureau of medical and social examination in Saint-Petersburg].

The article demonstrate data on the primary and re-disability in the elderly, due to coronary artery disease and the results of expert assessment of citizens in the Bureau of Medical and Social Expertise of St. Petersburg from 2006 to 2012. The features of the level, structure, dynamics and distribution by disability groups in the retirement age are presented in comparison with the group of disabled people of the able-bodied age.

[Features of living activity limitations of elderly people with heart ischemic disease after surgical myocardial revascularization].

The article presents a comparative analysis of vital activity restriction in patients with coronary heart disease (CHD) after surgical myocardial revascularization in elderly and working age patients. It is demonstrated that elderly patients have some features of vital activity restriction, which is necessary to take into account in medical social expertise and rehabilitation program development.

Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee.

Introduction: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes. This study was designed to compare the effectiveness and safety of flavocoxid to naproxen in subjects with moderate to severe osteoarthritis (OA) of the knee.

Methods: In this randomized, multicenter, double-blind study, 220 subjects were assigned to receive either flavocoxid (500 mg twice daily) or naproxen (500 mg twice daily) for 12 weeks.

[Restrictions of ability to live on patients of advanced age with arterial hypertension].

Features of restriction of ability to live after invalids of advanced age suffering from arterial hypertension are investigated.