Interpersonal Maneuvers of Manic Patients.

(Reprinted with the permission 1974; 131: 250-255).

Detection of group C rotavirus in infants with extrahepatic biliary atresia.

The purpose of this retrospective study was to examine liver tissue from patients with cholestatic disease for the presence of group C rotavirus RNA. The reverse transcriptase-polymerase chain reaction (PCR) for genes 5 and 6 was used, and the PCR products were subjected to liquid hybridization with a 32P-labeled probe. A second amplification with nested primers was also used.

Rapid tolerance to the motor effects of p-chloroamphetamine in rats.

Studies were designed to test the hypothesis that tolerance to the effect of p-chloroamphetamine (PCA) on motor activity in rats would develop with repeated injections. In related biochemical studies the effects of single or repeated doses of PCA on the in vitro synaptosomal uptake of 3H-NE and 3H-DA and on the in vivo metabolism of intraventricularly administered 3H-NE and 3H-DA were investigated. The administration of 10 mg/kg of PCA induced a complex behavioral syndrome, which was quantified by scoring specific symptoms after direct observation.

Stress polycythemia--a pathophysiologic study.

Two patients with "Gaisböck syndrome" (stress polycythemia) were found to have been under chronic "stress" with REM sleep decrease, decreased nocturnal ADH-like activity and consequent nocturnal water loss. The role of REM decrease with chronic "stress" in causing secondary decrease in nocturnal ADH-like activity was emphasized as the means by which "stress" caused the blood volume changes seen with these two patients. Some factors that possibly could play a role in the pathophysiology of this syndrome were ruled out and other factors not studied here were considered for future investigation.

Interaction of physostigmine and delta-9-tetrahydrocannabinol in man.

To investigate the hypothesis that delta-9-tetrahydrocannabinol (THC), the major psychoactive ingredient of marihuana, acts by interfering with cholinergic brain mechanisms, 0.75 to 1.25 mg of physostigmine, a centrally active cholinergic drug, was given intravenously to 5 normal volunteers who had ingested 20 to 40 mg of THC 2 hours earlier.