Publications by authors named "el-Far A"
Gold nanoparticles mediate suppression of angiogenesis and breast cancer growth via MMP-9/NF-κB/mTOR and PD-L1/PD-1 signaling: integrative in vitro validation and network pharmacology insights.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Gold nanoparticles (AuNPs) have emerged as promising candidates for cancer therapy due to their unique physicochemical properties and biocompatibility. In this study, we investigate the synthesis, characterization, and therapeutic potential of AuNPs in breast cancer treatment. Further, it establishes a comprehensive understanding of the mechanisms by which AuNPs suppress angiogenesis and breast cancer growth, identifying novel targets and signaling nodes contributing to the anti-tumor effects of AuNPs.
View Article and Find Full Text PDFThe retracts the article "Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart" [...
View Article and Find Full Text PDFBackground: Nanotechnology has been recognized as a viable technology for enhancing agriculture, particularly in the plant pathogen management area. Alfalfa mosaic virus (AMV) is a global pathogen that affects many plant species, especially economically valuable crops. Currently, there is less data on the interaction of nanoparticles with phytopathogens, particularly viruses.
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- Recurrent pregnancy loss (RPL) is defined as two or more consecutive miscarriages and may be influenced by immune system and genetic factors, particularly the Vitamin D Binding Protein (VDBP).
- The study involved 198 women with a history of multiple miscarriages, focusing on the role of Vitamin D levels and its impact on immune function, using various laboratory techniques to analyze these relationships.
- Results indicated that low Vitamin D is linked to reduced natural killer (NK) cell activity and altered protein levels (like VDBP and HLA-G1), suggesting that Vitamin D deficiency could disrupt adenosine metabolism, contributing to reproductive complications.
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- The journal has decided to retract the article titled "Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer".
- The retraction indicates that there may have been issues with the research or methodology presented in the article.
- This action highlights the importance of scientific integrity and the peer review process in publishing accurate and reliable research.
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- Newcastle disease (ND) is a highly destructive virus affecting poultry, leading to global economic losses, prompting research into Glycyrrhiza glabra (G. glabra) as a potential protective treatment for chickens.
- An experiment with 90 chicks assessed the impact of G. glabra on NDV-challenged birds, revealing that treated chicks showed significantly reduced symptoms, morbidity, and mortality rates compared to the untreated group.
- Findings included improvements in various health markers, reduced viral shedding, fewer lesions, and less severe pathological changes, supporting the hypothesis that G. glabra can effectively combat Newcastle disease virus infection.
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- Renal function disruption can significantly impact overall health, making it crucial to understand how harmful substances like acrylamide (ACR) affect the kidneys.
- This study examined how ACR causes kidney damage by targeting specific proteins and pathways, and also assessed the protective effects of green-synthesized zinc oxide nanoparticles (ZNO-MONPs) over a 60-day period with various treatment groups.
- Results showed that ZNO-MONPs effectively reduced ACR-induced kidney tissue damage and oxidative stress, suggesting they could be a potential protective treatment against ACR's harmful effects on renal function.
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- The study investigates the harmful effects of oral exposure to acrylamide (AD) on lung function, focusing on how it relates to inflammation, oxidative stress, and cell death (pyroptosis).
- It uses a rat model to show that AD lowers specific miRNA expressions, leading to increased cell death and damage in lung tissue, as well as the activation of harmful proteins.
- The introduction of zinc oxide nanoparticles combined with moringa extract shows potential protective effects against the toxicity of acrylamide, enhancing the miRNA responses and reducing lung damage.
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- Diabetes mellitus (DM) causes organ dysfunction, and a study investigated the effects of thymoquinone (TQ) on various health parameters in diabetic rats induced by streptozotocin (STZ).
- The findings indicated that TQ improved insulin levels, reduced hyperglycemia and hyperlipidemia, and restored liver function indicators, overall benefiting the health of the diabetic rats.
- Moreover, TQ exhibited anti-inflammatory and anti-apoptotic effects, suggesting it may serve as a promising natural supplement for managing diabetes and enhancing liver health.
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- * Male albino rats were divided into five groups; those exposed to GBPs received licorice root extract in varying doses for three weeks to evaluate its protective effects.
- * Results showed that the highest dose of licorice extract significantly lowered harmful enzyme levels and reduced inflammation and cell death, suggesting licorice could be a key factor in making agricultural practices more sustainable.
Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles.
Badriyah S Alotaibi Amany Abdel-Rahman Mohamed Yasmina M Abd-Elhakim Ahmed E Noreldin Moustafa Elhamouly
Front Pharmacol
May 2024
Article Synopsis
- - The insecticide fenpropathrin (FNE) has been linked to neurotoxic effects similar to those seen in Parkinson's disease, affecting dopaminergic markers and causing oxidative stress in rat models.
- - A study involved 40 male rats divided into four groups to examine the effects of FNE exposure and the protective role of curcumin-encapsulated chitosan nanoparticles (CRM-Chs-NPs) over 60 days.
- - Results showed that FNE led to various harmful changes in the brain, while CRM-Chs-NPs helped reduce toxicity by improving mitochondrial function, enhancing antioxidant activity, and supporting anti-inflammatory responses.
A low-protein (LP) diet may alleviate the environmental impact of chicken meat production by reducing nitrogen excretion and ammonia emissions. Thus, this study investigated the effect of a 15% reduced protein diet with or without amino acid (AA) supplementation on the growth performance of broiler chicks from 10 to 35 days of age and the underlying mechanism for loss of skeletal muscle mass. Thirty-six male broiler chicks were allocated to three experimental groups based on body weight: control, LP, and essential AA-supplemented LP (LP+AA).
View Article and Find Full Text PDFGlobal warming can be defined as the detectable increase in average global temperature in the last ten years regarding frequency and intensity. Climate change represents a long-term detectable climatic variability. The climatic system of the earth is disrupted because of the continuous production of greenhouse gases, which raises the risk of the emergence and re-emergence of human pathogens.
View Article and Find Full Text PDFRecent advances in nanotechnology have offered novel ways to combat cancer. By utilizing the reducing capabilities of Lactobacillus acidophilus, silver nanoparticles (AgNPs) are synthesized. The anti-cancer properties of AgNPs have been demonstrated in previous studies against several cancer cell lines; it has been hypothesized that these compounds might inhibit AMPK/mTOR signalling and BCL-2 expression.
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- The study investigates the impact of diosgenin (DSG) on oxidative stress caused by D-galactose (D-gal), focusing on its potential protective effects on brain and liver health.
- D-gal induced oxidative injuries and aging markers, but DSG helped enhance the levels of important antioxidants and decreased harmful aging-related proteins.
- The findings suggest that taking DSG supplements could be a natural way to combat aging by improving antioxidant defenses and reducing inflammation and cell death.
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- Anticoccidial drugs have been traditionally used to treat avian coccidiosis, but issues like resistance and health concerns have prompted the exploration of alternative treatments in broiler chickens.
- A study with 150 1-day-old male Cobb broiler chicks tested various treatments, finding that a 0.2% dose of a specific treatment significantly reduced symptoms of coccidiosis and improved meat quality without altering breast meat color.
- Additionally, the treatment boosted certain serum cholesterol levels while lowering others, and reduced harmful effects on the intestinal epithelium, indicating its potential as a safe dietary option for broilers.
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- The study investigates the effectiveness of dietary lysozyme (LYZ) compared to avilamycin (AVI) as alternatives to antibiotics in broiler chickens, focusing on growth performance, gut health, and immunity.
- Both LYZ and AVI improved key growth metrics and upregulated important immune-related genes compared to a control group that received no supplementation.
- LYZ supplementation resulted in better intestinal health and immune response, including reduced harmful bacteria and improved vaccination titers, suggesting it could be a beneficial alternative to traditional antibiotics in poultry diets.
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- The study examines the therapeutic effects of gingerol (6-gingerol) and sorafenib on liver cancer (HCC) induced by a chemical called p-Dimethylaminoazobenzene (DAB) in mice, focusing on their impact on specific gene expressions related to cancer.
- Results showed that gingerol reduced oxidative stress markers and improved the expression of tumor suppressor genes while decreasing oncogene levels, suggesting it has potential as an effective therapy for HCC when used alone or in combination with sorafenib.
- The findings indicate that ginger could play a significant role in cancer treatment by modulating oxidative stress and affecting key signaling pathways, which could lead to new
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- * The study investigated the protective effects of ChV on AFT-induced kidney damage and egg quality in quails, finding that AFT exposure led to kidney injury and decreased egg quality due to increased oxidative stress and inflammatory responses.
- * ChV supplementation improved kidney health and egg quality by reducing AFT-related oxidative stress and inflammation, suggesting that dietary inclusion of ChV could be a viable approach to mitigate the negative effects of AFT.
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- Chronic immobilization stress is linked to various neuropsychiatric disorders, and this study investigated how chia seed oil (CSO) can help mitigate its effects in rats subjected to stress.
- The results showed that CSO treatment significantly reduced stress biomarkers and inflammation, restored neuronal health, and improved gene expression related to brain function when compared to untreated stressed rats.
- The findings suggest that CSO has potential as a treatment for stress-induced brain issues by targeting specific proteins involved in inflammation and cell death, highlighting the need for further research in humans.
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- - Cypermethrin (CYP), a synthetic insecticide, poses significant health risks to humans and animals, leading to liver and kidney damage as observed in a study with Wistar rats.
- - The study involved administering CYP and Panax ginseng root extract separately and in combination to assess their effects on health markers, revealing that CYP resulted in weight loss, increased liver enzymes, and inflammatory markers, while Ginseng appeared to counteract these negative effects.
- - Ginseng improved antioxidant activity, reduced inflammation, and positively impacted liver and kidney tissue health, suggesting its potential as a protective agent against CYP-induced oxidative damage.