The ameliorative role of -loaded chitosan nanoparticles on induced acute lung injury: Targeting TLR/NF-κB signaling pathways.

Background: Acute lung injury (ALI) is a severe condition distinguished by inflammation and impaired gas exchange in the lungs. a common bacterium, can cause ALI through its virulence factors. is a medicinal plant that has been traditionally used to treat a variety of illnesses due to its anti-inflammatory properties.

Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA.

Background: Autophagy is a well-preserved mechanism essential in minimizing endoplasmic reticulum stress (ER)-related cell death. Defects in β-cell autophagy have been linked to type 1 diabetes, particularly deficits in the secretion of insulin, boosting ER stress sensitivity and possibly promoting pancreatic β-cell death. Quercetin (QU) is a potent antioxidant and anti-diabetic flavonoid with low bioavailability, and the precise mechanism of its anti-diabetic activity is still unknown.

Morin suppresses mTORc1/IRE-1α/JNK and IP3R-VDAC-1 pathways: Crucial mechanisms in apoptosis and mitophagy inhibition in experimental Huntington's disease, supported by in silico molecular docking simulations.

Aims: Endoplasmic reticulum stress (ERS) with aberrant mitochondrial-ER contact (MERC), mitophagy, and apoptosis are interconnected determinants in neurodegenerative diseases. Previously, we proved the potential of Morin hydrate (MH), a potent antioxidant flavonoid, to mitigate Huntington's disease (HD)-3-nitropropionic acid (3-NP) model by modulating glutamate/calpain/Kidins220/BDNF trajectory. Extending our work, we aimed to evaluate its impact on combating the ERS/MERC, mitophagy, and apoptosis.

Pervious Concrete Made with Recycled Coarse Aggregate and Reinforced with Date Palm Leaves Fibers.

This study considers 12 pervious concrete mixes incorporating 100% recycled coarse aggregate from old concrete demolition waste and containing various amounts of natural fine aggregate and date palm leaves fibers. First, the properties of the recycled aggregate in terms of their particle size distribution, abrasion resistance, crushing values, specific gravity and water absorption are obtained. Next, the pervious concrete density, compressive strength, tensile strength, permeability and porosity are determined by experimental testing following the relevant standards.

Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats.

Background: Mitoxantrone has proved efficacy in treatment of multiple sclerosis (MS). The fact that physical exercise could slow down the progression of disease and improve performance is still a debatable issue, hence; we aimed at studying whether combining mitoxantrone with exercise is of value in the management of MS.

Methods: Thirty-six male rats were divided into sedentary and exercised groups.

Neuroprotective role of galantamine with/without physical exercise in experimental autoimmune encephalomyelitis in rats.

Aims: The fact that physical activity besides central cholinergic enhancement contributes in improving neuronal function and spastic plasticity, recommends the use of the anticholinesterase and cholinergic drug galantamine with/without exercise in the management of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS).

Materials And Methods: Sedentary and 14 days exercised male Sprague Dawley rats were subjected to EAE. Hereafter, exercised rats continued on rotarod for 30 min for 17 consecutive days.

Developmental neurotoxic effects of Malathion on 3D neurosphere system.

Developmental neurotoxicity (DNT) refers to the toxic effects induced by various chemicals on brain during the early childhood period. As human brains are vulnerable during this period, various chemicals would have significant effects on brains during early childhood. Some toxicants have been confirmed to induce developmental toxic effects on CNS; however, most of agents cannot be identified with certainty.

Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban.

This study aims to detect the antischistosomal properties of the plants' Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban methanol extract against Schistosoma mansoni in infected mice, including determination of total protein and albumin levels and the activities of alanine and aspartate transaminases (AlT, AsT) and acid and alkaline phosphatases (AcP and AkP) enzymes in the serum of infected treated mice. Male Swiss albino mice were infected with S. mansoni and orally treated with methanol extract of the plants C.

Schistosomiasis in newly reclaimed areas in Egypt. 2--Patterns of transmission.

The distribution, abundance and seasonality of infected Biomphalaria alexandrina and Bulinus truncatus were studied for 2 years (1992-1994) in two newly reclaimed areas, namely El Manayef and El-Morra areas located on both sides of Suez Canal near Ismailia City. The results confirm the occurrence of transmission of both Schistosoma mansoni and S. haematobium since infected snails of both species were recovered in these areas.

Schistosomiasis in newly reclaimed areas in Egypt. 1-distribution and population seasonal fluctuation of intermediate host snails.

Two newly reclaimed areas located west & east of Suez Canal, namely El Manayef area and El Morra area, were studied for patterns of distribution and population seasonal fluctuation of Biomphalaria alexandrina and Bulinus truncatus, the intermediate host snails of Schistosoma mansoni and S. haematobium, respectively. In this study Geographic Information System (GIS) techniques were utilized for producing maps and analyzing the results.

Effect of six non-target snails on Schistosoma mansoni miracidial host finding and infection of Biomphalaria alexandrina under laboratory conditions.

Six snail species naturally associated with Biomphalaria alexandrina, the snail host of Schistosoma mansoni in Egypt, were tested under standard laboratory conditions, for impact on miracidial host findings and infection of the snail host. These snails are the prosobranchs Melanoides tuberculata, Cleopatra bulimoides, Bellamys unicolor and Lanistes carinatus, the pulmonates Planorbis planorbis and Physa acuta. The tested snail ssp.

Susceptibility of Biomphalaria alexandrina to the plant Azolla pinnata and some herbicides in relation to infection with Schistosoma mansoni miracidia.

Molluscicidal activity of the herebicides 2,4-D and Graminol, as well as both extracts and dry powder of the plant Azolla pinnata were evaluated against B. alexandrina snails. It was observed that 2,4-D proved to be the most toxic compound among he tested ones, showing LC90 of 52 ppm after 24 h of exposure.

Effect of the plant Azolla pinnata on survival, growth rate, fecundity and hatchability of egg-masses of Biomphalaria alexandrina snails.

Data indicated that Azolla pinnata plants variously reduce the growth rate of Biomphalaria alexandrina snails expressed as net increase in shell diameter (direct or indirect exposure). The plant density played an important role in this respect. The higher the plant density was the lower the growth rate and vice versa.

Population dynamics and schistosomal infection of Biomphalaria alexandrina in four irrigation canals in Egypt.

The natural growth, reproductivity, mortality and schistosomal infection of Biomphalaria alexandrina, the snail vector of Schistosoma mansoni in Egypt, were studied for one year in four irrigation canals, namely El-Khassa and Radwan (Giza Governorate) and Sendebis and Sanafeer (Qalyoubiya Governorate). Radwan canal contains a considerably dense Biomphalaria population and three generations of snails (parents generation and autumn and spring generations) were recognized. Two phases of growth were distinguished in both autumn and spring generations, a faster phase followed by a slower one.

Ecology of Biomphalaria alexandrina the snail vector of Schistosoma mansoni in Egypt.

The patterns of spreading and seasonal variation of population density of Biomphalaria alexandrina, the snail vector of Schistosoma mansoni in Egypt, in correlation with some environmental parameters were studied for 1988-1990 in four irrigation canals in Giza and Qalyoubiya Governorates. Results shown that the spreading patterns of snails along canals are changeable because of water current and irrigation activities. The snail population density showed two peaks, different in height, in April-May and November-December separated by two bottoms following the Winter Closure and during the hot summer season.

Helisoma duryi: its present range of distribution and implications with schistosomiasis snails in Egypt.

The range of distribution of Helisoma duryi, a potential competitor to schistosomiasis snail vectors in Egypt, was determined in the south of Nile Delta. Results show that H. duryi was found in the River Nile, Geziret El Kerateyeen banks, Damietta and Rosetta Branches, Tawfiky and Menoufy Canals and their branches and Bassoussiya, Bahadiya and Sheshaa canals and their branches.

Effect of Schistosoma mansoni infection, starvation and molluscicides on acid phosphate, transaminases and total protein in tissues and hemolymph of Biomphalaria alexandrina.

The activities of GOT and GPT in the hemolymph of B. alexandrina were significantly decreased by S. mansoni infection.

The prepatent period and cercarial production of Schistosoma haematobium in Bulinus truncatus (Egyptian field strains) at different constant temperatures.

The developmental time of Schistosoma haematobium in Bulinus truncatus snails (field strains) was determined in the laboratory at different constant temperatures between 18 and 32 degrees C. The basic relationship between the length of the minimum prepatent period (y, in days) and the temperature (x, in degree C) is given by the hyperbolic formula y = 295/(x-15.3), 15.