Publications by authors named "e V Gladkova"
Article Synopsis
- In lab tests, shorter alkyl substitutes (C5 and C7) showed a stronger ability to stimulate glucose uptake in liver cells compared to longer ones (C10 and C12), while all derivatives performed better than the original berberine.
- In animal studies, the C12 derivative improved glucose metabolism in mice over four weeks, yet it also caused liver damage indicators by the end of the experiment.
Article Synopsis
- Novel 9-N-alkyltetrahydroberberine derivatives were created, and one particular compound with the longest aliphatic chain was chosen for testing on obese mice showing impaired glucose tolerance and non-alcoholic fatty liver disease.
- After administering this compound at a dose of 15 mg/kg for four weeks, the mice exhibited improved insulin sensitivity, lower fasting glucose levels, and better glucose tolerance during the OGTT.
- The compound also decreased blood lactate and liver glucokinase levels without any toxic effects observed in the animals, suggesting that this derivative has significant hypoglycemic potential and encourages further research on similar compounds.
Subchondral remodeling is an important pathogenic mechanism in primary gonarthrosis progress. The role of altered metabolism of osseous tissue in early signs of articular pathology remains vague, and the informative value of biochemical markers is discussible. Our research involved 103 patients (64 women and 39 men) with 0-I gonarthrosis stages and 103 healthy individuals (72 women and 28 men) of 36 to 50 years old.
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- Berberine is known for lowering blood glucose levels, but its effectiveness is hampered by a high required dose and poor absorption in the body.
- Researchers created a new compound derived from berberine, called 9-(hexylamino)-2,3-methylenedioxy-10-methoxyprotoberberine chloride, which shows strong blood sugar-lowering properties.
- In tests on obese mice with type 2 diabetes, this new compound improved insulin sensitivity, glucose tolerance, reduced body weight and fat, and positively affected liver and pancreatic health.
Comparison of activity of antibiotics against Staphylococcus aureus strains in their plankton form and in biofilms of varying maturity showed that the concentrations of antibiotics causing death of 90% S. aureus strains (MIC) in their plankton form was 0.07-2.
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