3D-Printable Elastomers for Real-Time Autonomous Self-Healing in Soft Devices.

Photocurable self-healing elastomers are promising candidates for producing complex soft devices that can mend damage. However, the practicality of these materials is limited by reliance on external stimuli, custom synthesis, manual realignment, and multihour healing cycles. This paper introduces a tough 3D-printable hybrid acrylate/thiol-ene elastomer (prepared with commercially available precursors) that exhibits nearly instantaneous damage repair in the absence of external stimuli.

Regioisomeric π-Extended Nanographene with Long-Lived Phosphorescence Afterglow.

The cutouts of graphene sheets, particularly those with a nonplanar topology, present vast opportunities for advancement. Even a slight deviation from the planar structure can lead to intriguing (chiro)optical features for helically twisted nanographenes. In this context, we introduce two regioisomeric π-extended nanographenes that exhibit distinct excited-state characteristics.

Phase 2 Open-Label Study of Sacituzumab Govitecan as Second-Line Therapy in Patients With Extensive-Stage Small Cell Lung Cancer: Results From TROPiCS-03.

Introduction: The phase 2 TROPiCS-03 study evaluated the efficacy/safety of sacituzumab govitecan (SG) as second-line treatment in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC).

Methods: TROPiCS-03 (NCT03964727) is a multicohort, open-label, phase 2 basket study in solid tumors, including ES-SCLC. Adults with ES-SCLC that progressed after one prior line of platinum-based chemotherapy and anti-programmed death-(ligand) 1 (PD-[L]1) therapy received SG 10 mg/kg on days 1 and 8 of a 21-day cycle.

Dimensional confinement and superdiffusive rotational motion of uniaxial colloids in the presence of cylindrical obstacles.

In biological systems such as cells, the macromolecules, which are anisotropic particles, diffuse in a crowded medium. In the present work, we have studied the diffusion of spheroidal particles diffusing between cylindrical obstacles by varying the density of the obstacles as well as the spheroidal particles. Analytical calculation of the free energy showed that the orientational vector of a single oblate particle will be aligned perpendicular, and a prolate particle will be aligned parallel to the symmetry axis of the cylindrical obstacles in equilibrium.

CRISPR/Cas9-Based Protocol for Precise Genome Editing in Induced Pluripotent Stem Cells.

The advent of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based genome editing has marked a significant advancement in genetic engineering technology. However, the editing of induced pluripotent stem cells (iPSCs) with CRISPR presents notable challenges in ensuring cell survival and achieving high editing efficiency. These challenges become even more complex when considering the specific target site.

A Longitudinal Interview Study of People with Long COVID: Uncertainties, Liminality, and Processes of Becoming.

Current estimates indicate around 6% of US adults have experienced long COVID symptoms. Given the novelty of both COVID and long COVID, those who continue to be ill after an initial SARS-CoV-2 infection have little precedence on which to rely when navigating the medical (e.g.

Clinician Perspectives Highlight the Need for Early Dyadic Coping Skills for People Living With Amyotrophic Lateral Sclerosis.

Context: A diagnosis of ALS can be challenging, and many people find ways to adapt. At the same time, emotional distress can arise early after an ALS diagnosis even when high quality multidisciplinary care is provided. When emotional distress occurs, it can become chronic over time, and can affect both the person living with ALS and their care-partner (together called a dyad).

Size and canopy characteristics of community reserves determine primate occupancy in the state of Meghalaya, India, and implications for its conservation.

Globally, the effective protected area network is one of the last resorts for conserving biodiversity. The nature of protected areas depends on the land ownership of the respective countries including India. The landholding in the northeastern states of India remains with native people, thus, 'Community Reserve' (CR) was introduced in 2003.

Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study.

Objective: To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation.

Study Design: Retrospective multi-institutional cohort study.

Setting: Eleven tertiary academic medical centers across Germany, Denmark, and the United States.

Immunological mechanisms of tuberculosis susceptibility in TB-infected individuals with type 2 diabetes mellitus: insights from mycobacterial growth inhibition assay and cytokine analysis.

Unlabelled: Several studies have highlighted the increased risk of active tuberculosis (TB) in individuals with diabetes mellitus (DM), especially in TB-endemic regions. This dual burden poses significant challenges for TB control efforts. However, there is a lack of reliable laboratory tools to identify individuals at higher risk, and the immunological mechanisms underlying this susceptibility are poorly understood.

Contributions of neurologists to diagnostic timelines of ALS and thinkALS as an early referral instrument for clinicians.

To evaluate neurologists and other clinicians' contributions to U.S. ALS diagnostic timelines.

Metaheuristic optimized complex-valued dilated recurrent neural network for attack detection in internet of vehicular communications.

The Internet of Vehicles (IoV) is a specialized iteration of the Internet of Things (IoT) tailored to facilitate communication and connectivity among vehicles and their environment. It harnesses the power of advanced technologies such as cloud computing, wireless communication, and data analytics to seamlessly exchange real-time data among vehicles, road-side infrastructure, traffic management systems, and other entities. The primary objectives of this real-time data exchange include enhancing road safety, reducing traffic congestion, boosting traffic flow efficiency, and enriching the driving experience.

Osteogenic potential of esculetin-loaded chitosan nanoparticles in microporous alginate/polyvinyl alcohol scaffolds for bone tissue engineering.

Bone tissue engineering (BTE) is an emerging strategy for the treatment of critical bone defects using biomaterials and cells. Esculetin (ES), a coumarin phytocompound, has demonstrated therapeutic potential, although its osteogenic effects remain insufficiently explored. Owing to its hydrophobic nature, which limits its bioavailability, this study developed a drug delivery system using chitosan nanoparticles (nCS) to achieve sustained release of ES.

Construction of Alkaloid-Type Bis Carbazoles via Pd(II)-Catalyzed C-H Functionalization.

We report the construction of unsymmetrical dimeric carbazoles and π-extended bis carbazoles (having an aryl ring spacer) via the C-H functionalization route. Generally, oxidative coupling and traditional cross-coupling reactions have been used to construct bis- and π-extended carbazoles. Natural bis carbazole alkaloids and synthetic dimeric carbazoles are important molecules in medicinal, materials chemistry research.

Esculin, a Coumarin Glucoside Prevents Fluoride-Induced Oxidative Stress and Cardiotoxicity in Zebrafish Larvae.

Fluoride (F) is a major groundwater contaminant spread across the world. In excess concentrations, F can be detrimental to living beings. F exposure is linked to cellular redox dyshomeostasis, leading to oxidative stress-mediated pathologies including heart dysfunction.

UPLC-QToF-MS/MS screening and characterization of Wight and in vitro assessment of its antioxidant, anticancer, and anti-inflammatory potential.

belongs to the Lamiaceae family and is locally known as Badichang or mahasindhu. In this study, we performed Soxhlet extraction to prepare methanolic and hydromethanolic extracts, followed by quantification of their total phenolic content and total flavonoid content. Qualitative analysis of both the extracts was conducted to determine the presence of different phytochemicals.

Proteomic profiling of oral squamous cell carcinoma tissues reveals altered immune-related proteins: implications for personalized therapy.

Objectives: Oral squamous cell carcinoma poses a substantial global health challenge marked by rising mortality rate. Recently, immunotherapy has shown promising results in cancer management by enhancing immune response. Thus, identifying additional immune-related markers is critical for advancing immunotherapy treatments.

Safety Outcomes of Balloon Dilation Eustachian Tuboplasty in Pediatric Patients: A Follow-Up Study.

Objectives: Balloon dilation eustachian tuboplasty (BDET) has gained popularity as a treatment modality for chronic eustachian tube dysfunction (ETD) in both adults and children. Although its safety and efficacy in the adult population have been well described, very few large-sample studies assessing its safety profile have been performed in the pediatric population. This study serves as a follow-up to a previously published analysis assessing the safety of BDET in the pediatric population.

COVID-19 in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): a propensity matched analysis (2020-2021).

Background: By 2023, COVID-19 had caused 6.8 million deaths in the United States. COVID-19 presents more severely in leukemia compared to solid tumors (OR 1.