Publications by authors named "al-Salameh A"
Syndromic primary hyperparathyroidism has several features in common: younger age at diagnosis when compared with sporadic primary hyperparathyroidism, often synchronous or metachronous multi-glandular involvement, higher possibility of recurrence, association with other endocrine or extra-endocrine disorders, and suggestive family background with autosomal dominant inheritance. Hyperparathyroidism in multiple endocrine neoplasia type 1 is the most common syndromic hyperparathyroidism. It is often asymptomatic in adolescents and young adults, but may be responsible for recurrent lithiasis and/or bone loss.
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- Smoking contributes to insulin resistance and negatively impacts beta-cell function, both of which are poorly understood factors linked to the development of type-2 diabetes.
- Active smoking harms glycemic control in both type-1 and type-2 diabetics, increasing all-cause mortality and exacerbating diabetes-related complications, while its effects on specific complications are still debated.
- There’s a lack of comprehensive data on smoking cessation strategies tailored for diabetic patients, highlighting the need for diabetes specialists to actively engage in supporting smoking cessation efforts.
Purpose: To assess the incidence of congenital hypothyroidism (CH) and acquired hypothyroidism (AH) between 2014 and 2019 in continental France.
Methods: New cases of CH and AH were identified using the French National Health Data System (Système Nationale des Données de Santé, SNDS). Temporal trends were studied using linear regression models.
Background: Epidemiological data regarding thyroid diseases are lacking, in particular for occupationally exposed populations.
Objectives: To compare the risk of hypothyroidism and hyperthyroidism between farming activities within the complete population of French farm managers (FMs).
Methods: Digital health data from retrospective administrative databases, including insurance claims and electronic health/medical records, was employed.
Article Synopsis
- A study in Picardy, France, found varying levels of thyroid-stimulating hormone (TSH) in newborns, prompting an investigation into potential links with environmental pollutants.
- Researchers analyzed data from 6,249 mothers and their babies born without congenital hypothyroidism in 2021, examining how exposure to pollutants during pregnancy might affect TSH levels.
- Results showed that higher exposure to pollutants like perchlorate and nitrates in tap water, as well as particulate matter in the air, was significantly connected to increased TSH concentrations in newborns.
Background: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization.
Methods: We collected data on adult patients hospitalized with COVID-19 at Amiens University Hospital. We compared TSH levels between inpatients with critical (intensive care unit admission and/or death) versus non-critical COVID-19.
Purpose: Metabolic changes during the perinatal period are known to promote obesity and type-2 diabetes in adulthood via perturbation of the microbiota. The risk factors for metabolic disorders include a high-fat diet (HFD) and exposure to pesticide residues. The objective of the present study was to evaluate the effects of perigestational exposure to a HFD and chlorpyrifos (CPF) on glycemia, lipid profiles, and microbial populations in Wistar dams and their female offspring.
View Article and Find Full Text PDFMale sex is a major cardiovascular risk factor in the general population, with men showing higher age-adjusted prevalence of cardiovascular disease than women. Diabetes, another major cardiovascular risk factor, affects cardiovascular risk differentially between men and women. Data from prospective observational studies showed that women with diabetes had greater relative risk of cardiovascular events than men with diabetes, leading to a smaller difference between diabetic men and women than between non-diabetic men and women in terms of cardiovascular disease.
View Article and Find Full Text PDFObjective: Since the outbreak of the COVID-19 pandemic, several cases of pituitary apoplexy (PA) following a SARS-CoV-2 infection have been described in several countries. Here, we describe a case series of PA occurring in the aftermath of a SARS-CoV-2 infection to alert physicians about possible neuro-endocrinological damage caused by the virus that can lead to visual sequelae and hypopituitarism.
Design And Methods: We retrospectively identified all the adult patients treated at Amiens University Hospital between March 2020 and May 2021 for PA confirmed by cerebral imaging and following an RT-PCR-confirmed SARS-CoV-2 infection.
Article Synopsis
- Smoking significantly raises the risk of developing pre-diabetes and diabetes, and worsens health outcomes for those already diagnosed.
- A joint statement from two French-speaking associations highlights the negative effects of smoking on diabetes management and increased mortality risk.
- The paper includes evidence-based strategies for helping individuals with diabetes quit smoking through both medication and behavioral approaches.
Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19 have reported a favourable association between metformin and Covid-19-related outcomes in patients with type 2 diabetes mellitus (T2DM). This is not surprising since metformin affects many of the pathophysiological mechanisms implicated in SARS-CoV-2 immune response, systemic spread and sequelae. A comparison of the multifactorial pathophysiological mechanisms of Covid-19 progression with metformin's well-known pleiotropic properties suggests that the treatment of patients with this drug might be particularly beneficial.
View Article and Find Full Text PDFAims: There are few published data on sleep-disordered breathing (SDB) in type 1 diabetes (T1DM). Here, we used a combination of polysomnography and glucose variability assessment to screen for SDB.
Methods: In a prospective, single-centre study, adults with T1DM underwent polysomnography and continuous glucose monitoring during a single night.
Article Synopsis
- The study examined sex differences in severe outcomes of COVID-19 among adults with diabetes, analyzing data from 2,380 hospitalized patients.
- Findings revealed that females had a lower risk of invasive mechanical ventilation, death, and ICU admission compared to males, although this female advantage was less evident in overall in-hospital mortality.
- The research highlighted specific predictors of death linked to sex, emphasizing the need for tailored COVID-19 management strategies based on biological differences.
Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-occurrence of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumours (NETs) and/or pituitary adenomas. MEN1 can predispose patients to other endocrine and non-endocrine tumours, such as cutaneous tumours, central nervous system tumours and breast cancer. Endocrine tumours in patients with MEN1 differ from sporadic tumours in that they have a younger age at onset, present as multiple tumours in the same organ and have a different clinical course.
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- The study aimed to investigate the effects of prior metformin use on the health outcomes of type 2 diabetes patients hospitalized for COVID-19.
- An analysis of 2,449 patients showed that metformin users generally had better survival rates and lower mortality compared to non-users, particularly noted at days 7 and 28 after admission.
- The conclusion suggests that metformin may reduce the risk of death in diabetes patients with COVID-19, indicating its potential beneficial effects during hospitalization.
Background/objectives: A growing body of data suggests that obesity influences coronavirus disease 2019 (COVID-19). Our study's primary objective was to assess the association between body mass index (BMI) categories and critical forms of COVID-19.
Subjects/methods: Data on consecutive adult patients hospitalized with laboratory-confirmed COVID-19 at Amiens University Hospital (Amiens, France) were extracted retrospectively.
Background: Coronavirus disease 2019 (COVID-19) is a rapidly progressing pandemic, with four million confirmed cases and 280 000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID-19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs without diabetes.
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