Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation.

Objective: Microneedle patches based on dissolving, detachable microneedle technology (Russian patent No. 2652567; US patent EFS No. 32735812; WO/2019/231360) are novel dermatological products that allow safe, painless and effective reduction of epidermal wrinkles after six procedures.

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality - Part 1: ex vivo safety evaluation.

Objective: The aim of the paper presented herein is the description and safety evaluation of the process of dissolution of an 86-microneedle patch composed of hyaluronic acid, when applied topically to human abdominal skin explants. Such explants were chosen to replace the inability of obtaining periorbital skin. In order to evaluate penetration and dissolution of the microneedles, we employed histochemical methods and a fluorescent dye FITC (fluorescein isothiocyanate).

[Toxicological evaluation of nanosized colloidal silver, stabilized with polyvinylpyrrolidone, in 92-day experiment on rats. II. Internal organs morphology].

The aim of the study was to evaluate the safe doses of commercially available nanosized colloidal silver (NCS), stabilized with polyvinilpirrolidone (PVP, food additive E1201) when administered in gastrointestinal tract of rats in the 92-day experiment in terms of the morphological changes in the internals of animals. The sample studied contained non-aggregated nanoparticles (NPs) of silver belonging to size fractions with a diameter of less than 5 nm, 10-20 nm or 50-80 nm. 80% of NPs were inside the range of hydrodynamic diameters 10.

[Experience of using subcutaneous interstitial fluid for biomonitoring a dose load in workers of metallurgic industry].

Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907) but strong correlation (r = 0.

[Inhalation toxicity of nanodispersed manganese oxide aerosol].

The article presents results of experimental study concerning acute inhalation toxicity of nanodispersed manganese oxide widely used in novelty goods production. During the technology process, nano-dimensional manganese oxide aerosol could appear in workplace air--that causes danger of the workers' inhalation exposure. Findings are that the studied substance is a nanomaterial with prevalent fihiform particles measuring 15-29 nm.

Collection of analytes from microneedle patches.

Clinical medicine and public health would benefit from simplified acquisition of biological samples from patients that can be easily obtained at point of care, in the field, and by patients themselves. Microneedle patches are designed to serve this need by collecting dermal interstitial fluid containing biomarkers without the dangers, pain, or expertise needed to collect blood. This study presents novel methods to collect biomarker analytes from microneedle patches for analysis by integration into conventional analytical laboratory microtubes and microplates.

[Toxicological assessment of nanostructured silica. The acute oral toxicity].

Nanostructured amorphous silica (SiO2) is one of the priorities of nanomaterials, exposing human to the ever-increasing scale as a component of food additives, drugs and cosmetic products. According to numerous publications SiO2 nanoparticles (NPs) possess deleterious effects on animal and human cells in vitro and also exhibit inhalation toxicity. However, the biological effects in vivo of silica NPs taken orally are studied insufficiently.

[Effect of nanodispersed manganese oxide (III, IV) on morphological properties of various tissues and body systems].

The study of morphological features of tissue organs of experimental animals after a single intragastric administration of an aqueous suspension nanodis-dispersed manganese (III, IV) at doses of 2000, 3500 and 5000 mg/kg showed complex of morphological changes in the form of circulatory disorders up to hemostasis and bleeding which lead to changes in the structure of organs, enhanced apoptosis, activation of macrophage system by proliferation and macrophage phagocytosis of degradation products of cells, hypertrophy of lymphoid tissue of immune system; development of histiocytic infiltrates in parenchymal organs and central nervous system. With the introduction of microsized analogues in the same doses of the morphological changes in the circulatory system, macrophage system and immune organsfound predominantly in a dose of 5000 mg/kg. Changes were less significant and were presented as activation of macrophages in the liver in the form of activation of Kupffer cells, proliferation of lymphoid tissue in the spleen, lymph histiocytic infiltrates in the liver, kidney, medium size.

[Surgical treatment of cancer of the large intestine, complicated by intestinal obstruction].

Retrospective analysis of the treatment of 3,080 patients with cancer of the large intestine made it possible to distinguish compensated, sub- and decompensated degrees of the neoplastic stenosis and place the two last named into the category of a complicated course of cancer. In subcompensated stenosis (complications in 16.3% of cases, mortality 5.

[Radical and palliative combined surgery in the surgical treatment of cancer of the rectum].

Analysis of 186 combined resections and extirpations of the rectum for primary carcinoma, among which 31 were palliative operations, showed that the indications for them are limited with age from 21.7% in the young to 12.8% in patients over 60 years of age.

[Improvement of the effectiveness of the surgical treatment in cancer of the colon].

The authors studied the results of 585 resections of the colon and hemicolectomies which were performed for carcinoma; 105 of the operations were palliative. Among the radical operations 82 (17.1%) and among the palliative operations 28 (26.

[Combination primary restorative surgical interventions in cancer of the rectum in women].

In the past 15 years, 136 combined operations in women with locally disseminated rectal cancer were performed. Eighty-two (60.3%) operations were primary-restorative.

[Combined surgery in cancer of the colon].

The study was concerned with the short- and long-term results of 80 radical and 27 palliative combined resections and hemicolectomy for colonic cancer involving other organs or accompanied by solitary distant metastases. Tumor elements were morphologically identified in other resected organs (53.3%).

[Expansion of the indications for surgery in neglected rectal cancer].

Radical surgery was performed in 971 (86.0%) cases of rectal cancer, while palliative resection or extirpation of the rectum--in 158 (14.0%).

[Surgical treatment of complicated cancer of the rectum].

The authors make an analysis of results of the surgical treatment of 246 patients with rectum carcinoma complicated by partial or complete ileus, pararectal abscess and perforation of the tumor. The data obtained show that primary resection of the tumor especially with a one-step reestablishment of the colon continuity is one of the main prerequisites for the elimination of postoperative complications and lethality.