[A comparison analysis of the use of intravenous β-interferon-1a 30 mcg and subcutaneous β-interferon-1a 44 mcg in routine clinical practice of treatment in patients with multiple sclerosis].

Objective: to compare the results of treatment of multiple sclerosis (MS) with genfaxon, cinnovex and rebif.

Material And Methods: The drugs were used in the treatment of 80 patients of the Moscow West administrative okrug during 2014-2015. Thirty patients were treated with genfaxon, 20 with cinnoVex and 30 with the original drug rebif.

[Preventive and cessation therapy of mental disorders in patients with the acute coronary syndrome].

An open prospective trial of 93 inpatients divided into two main groups (61 patients) - with mental disorders (31) and without mental disorders (30) and a comparison group (32 patients) was carried out. All patients survived the acute coronary syndrome (myocardial infarction, unstable angina). The efficacy and safety of both preventive and cessation therapy with pantogam active in mean doses 1.

[The clinical significance of renal functional reserve].

Patients at risk to develop intraglomerular hypertension were denoted among those with chronic glomerulonephritis (CGN) basing on the relationships between various clinico-laboratory findings, clinical syndromes and markers of intraglomerular hypertension (low or absent renal functional reserve). The risk groups include CGN patients with urinary syndrome and arterial hypertension with nephrotic disease and serum creatinine over 1.4 mg/%, with renal damage typical for focal-segmental glomerulosclerosis or fibroplastic glomerulonephritis.

[Disorders of intrarenal hemodynamics in glomerulopathies].

The intrarenal hemodynamics was examined in 101 patients with chronic glomerulonephritis (CGN) and 111 patients with type I diabetes mellitus. Intrarenal hypertension was diagnosed from renal functional reserve (RFR) depletion. In CGN intrarenal hypertension was revealed in all clinical and morphological variants of nephritis: in 40% of patients with a nephrotic variant, in 25% with a latent variant and in 83% of patients with nephritis concurrent with the severe urinary syndrome.

[The antiproteinuric action of angiotensin-converting enzyme inhibitors in chronic glomerulonephritis and diabetic nephropathy].

Antiproteinuria effects of angiotensin-converting enzyme (ACE) inhibitors was studied in 23 patients with chronic nephritis (CN) and 32 patients with diabetic nephropathy (DN). CN patients received Capoten, DN patients were given enalapril. The drugs were also examined for the action on systemic arterial pressure, renal function and intrarenal hemodynamics.

[Acute pharmacological block of the renin-angiotensin system and the recovery of intrarenal hemodynamics in patients with chronic glomerulonephritis].

A test with capoten, inhibitor of angiotensin-converting enzyme, was employed to assess intrarenal hemodynamics (renal functional reserve-RFR) in 17 patients with morphologically confirmed chronic glomerulonephritis (CGN) in intact renal function without hypertension. Capoten induced three types of changes: RFR increased (9 cases, 7 patients recovered RFR), RFR without changes (5 cases), RFR decreased (3 cases, 2 patients lost RFR). It is stated that indications to inhibitors of angiotensin-II-converting enzyme in CGN should be based on the initial intrarenal hemodynamics and its changes in response to acute capoten test.

[The effect of a protein loading test on the fibrinolytic system in patients with chronic glomerulonephritis and amyloidosis].

Investigation of the reserves of the fibrinolytic system with the aid of protein stimulation was carried out in 10 patients with chronic glomerulonephritis and in 10 patients suffering from amyloidosis. All the patients manifested proteinuria exceeding 3.5 g/day and other symptoms of nephrotic syndrome of varying intensity.

[Hyperfiltration as a factor in the progression of chronic kidney diseases].

As many as 34 patients with nephrotic syndrome (NS) and 42 patients suffering from type I diabetes mellitus without clinical manifestations of renal damage were examined for clinical and morphological signs of hyperperfusion renal damage (hyperfiltration, microalbuminuria, specific morphological alterations). The lack of renal functional reserves was regarded as a criterion for the status of hyperfiltration (oral protein administration, intravenous injection of small doses of dopamine). The risk of the progression of renal failure by the hemodynamic type in NS amounted to 65%.

[The renal systems regulating water-electrolyte balance in the nephrotic syndrome].

A study was made of the role of renal factors regulating water and sodium balance in the body in chronic nephritis of the nephrotic type. 120 patients with the nephrotic syndrome were examined at different phases of its formation, namely at the phase of edema increase, stabilization phase, and at the phase of edema reduction. The rate of glomerular filtration and its relation to sodium excretion were defined.

[The renal functional reserve in the nephrotic syndrome].

Functional reserves of the kidneys (FRK) were examined in 29 patients with the nephrotic syndrome and in 14 healthy subjects. FRK were determined as the degree of the increase of endogenous creatinine clearance after stimulation with beef protein (0.7 g per kg bw) or dopamine (3 micrograms/min per kg bw).