In(III) pyridinecarboxylate complexes: Composition, solution equilibria estimation, bioevaluation and interactions with HSA.

Two In(III) - pyridinecarboxylates ([In(Pic)(NO)(HO)] (InPic; HPic = picolinic acid), [In(HDpic)(Dpic)(HO)]·5HO (InDpic; HDpic = dipicolinic acid), have been synthesized by one-step procedure. The complexes composition was confirmed by physicochemical analyses and X-ray diffraction confirmed molecular structure of both complexes. Moreover, complex species speciation was described in both systems by potentiometry and H NMR spectroscopy and mononuclear complex species were determined; [In(Pic)] (logβ = 6.

Influence of proline and hydroxyproline as antimicrobial and anticancer peptide components on the silver(I) ion activity: structural and biological evaluation with a new theoretical and experimental SAR approach.

Silver(I) complexes with proline and hydroxyproline were synthesized and structurally characterized and crystal structure analysis shows that the formulas of the compounds are {[Ag(Pro)(NO)]NO} (AgPro) (Pro = L-proline) and {[Ag(Hyp)(NO)]NO} (AgHyp) (Hyp = -4-hydroxy-L-proline). Both complexes crystallize in the monoclinic lattice with space group 2 with a carboxylate bidentate-bridging coordination mode of the organic ligands Pro and Hyp (with NH and COO groups in zwitterionic form). Both complexes have a distorted seesaw (C) geometry around one silver(I) ion with values of 58% (AgPro) and 51% (AgHyp).

Silver(I) complexes with amino acid and dipeptide ligands - Chemical and antimicrobial relevant comparison (mini review).

Diseases caused by various microorganisms accompany humans (as well as animals) throughout their whole lives. After germs penetration to the body, the incubation period and infection developing, an infection can cause mild or severe symptoms, not infrequently even death. The immune system naturally defends itself against pathogens with various mechanisms.

Ga(III) pyridinecarboxylate complexes: potential analogues of the second generation of therapeutic Ga(III) complexes?

A series of novel Ga(III)-pyridine carboxylates ([Ga(Pic)]·HO (GaPic; HPic = picolinic acid), HO[Ga(Dpic)]·HO (GaDpic; HDpic = dipicolinic acid), [Ga(Chel)(HO)(OH)]·4HO (GaChel; HChel = chelidamic acid) and [Ga(Cldpic)(HO)(OH)] (GaCldpic; HCldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis and X-ray diffraction confirmed complexes molecular structure, inter and intramolecular interactions and their influence to spectral and thermal properties. Moreover, complex species speciation was described in Ga(III)-HPic and Ga(III)-HDpic systems by potentiometry and H NMR spectroscopy and mononuclear complex species were determined; [Ga(Pic)] (logβ = 16.

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and case report.

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)]NO·HO ( AgNam), [Ag(HGly)](NO) (AgGly) (Nam - nicotin-amide, Gly - glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential.

Silver(I) pyrrole- and furan-2-carboxylate complexes - From their design and characterization to antimicrobial, anticancer activity, lipophilicity and SAR.

Two silver(I) complexes with biologically relevant heterocyclic ligands, pyrrole and furan-2- carboxylic acid, were synthesized and their composition was confirmed using elemental, spectral, thermal and structural analyses. The {[Ag(Py2c)]} (AgPy2c, Py2c = pyrrole-2-carboxylate) and {[Ag(Fu2c)]} (AgFu2c, Fu2c = furan-2-carboxylate) solubility and stability in biological test stock solution were confirmed by H NMR spectroscopy. The X-ray analysis has enabled us to determine typical argentophilic interactions and bridging carboxylate coordination mode of both ligands.

Antimicrobial and Anticancer Application of Silver(I) Dipeptide Complexes.

Three silver(I) dipeptide complexes [Ag(GlyGly)](NO) (AgGlyGly), [Ag(GlyAla)(NO)] (AgGlyAla) and [Ag(HGlyAsp)(NO)] (AgGlyAsp) were prepared, investigated and characterized by vibrational spectroscopy (mid-IR), elemental and thermogravimetric analysis and mass spectrometry. For AgGlyGly, X-ray crystallography was also performed. Their stability in biological testing media was verified by time-dependent NMR measurements.

The Texture and Structure of the Melt-Spun CoMnAl-Type Heusler Alloy.

The structure of the CoMnAltype Heusler alloy in the form of a melt-spun ribbon was studied by electron microscopy, electron back-scattered diffraction (EBSD), and X-ray diffraction. The melt-spun ribbon consists of a homogeneous single-phase disordered Heusler alloy at the wheel side of the ribbon and an inhomogeneous single-phase alloy, formed by cellular or dendritic growth, at the free surface of the ribbon. Cellular growth causes the formation of an inhomogeneous distribution of the elemental constituents, with a higher Co and Al concentration in the centre of the cells or dendritic arms and a higher concentration of Mn at the cell boundaries.

An in vitro selective inhibitory effect of silver(i) aminoacidates against bacteria and intestinal cell lines and elucidation of the mechanism of action by means of DNA binding properties, DNA cleavage and cell cycle arrest.

Novel silver(i) aminoacidate complexes {[Ag(HVal)(HO)(NO)]} (AgVal) and {[Ag(HAsp)(NO)]}·nHO (AgAsp) were prepared, investigated and fully characterized by vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis, X-ray crystallography and mass spectrometry. Their stability in DO and PBS buffer was verified by time-dependent H and C NMR measurements. Their in vitro antibacterial activity (against pathogenic Staphylococcus aureus CCM4223, Escherichia coli CCM4787) and that against probiotic bacteria Lactobacillus plantarum CCM7102 and Lactobacillus reuteri (L26) were determined and potential dosing concentration was evaluated.

In vitro biological evaluation and consideration about structure-activity relationship of silver(I) aminoacidate complexes.

Two silver(I) aminoacidate complexes {[Ag(L-HAla)(NO)]NO} (AgAla, complex 1, Ala = alanine) and {[Ag(L-Phe)]} (AgPhe, complex 2, Phe = phenylalanine) were prepared and characterized by elemental, spectral analysis (FT-IR, NMR techniques) and single crystal X-ray analysis in solid state and their solution stability was measured in biological testing time-scale by H NMR. The bridging coordination modes of the zwitterionic Ala and deprotonated Phe ligands led to the formation of 1D polymeric chains of the complexes. The significant argentophilic interactions are presented in the structure of AgAla.

Silver(i) pyridylphosphonates - synthesis, structure, stability and light-insensitivity investigation.

Two silver(i) complexes, {[Ag(2-pypo)(NO)]} (1) and [Ag(3-pypoH)(3-pypoH)] (2) (pypoH - pyridylphosphonic acid) were prepared and characterized by relevant methods in the solid state (elemental, spectral, thermal and structural analysis). Typical argentophilic interactions were observed in complex 1. The synthesized Ag(i) complexes were tested toward reduction to silver(0) using short wavelength UV-radiation and they revealed remarkable light-insensitivity in comparison to silver nitrate.

Silver pyridine-2-sulfonate complex - its characterization, DNA binding, topoisomerase I inhibition, antimicrobial and anticancer response.

In the current study the ability of silver pyridine-2-sulfonate complex to exert multiple biological activities is compared with the pharmacological action of silver sulfadiazine (AgSD). Polymeric form of {[Ag(py-2-SO)]} (AgPS) was synthesized and characterized by analytical techniques (IR, CHN, TG/DTA, MS) and its molecular formula was established. The crystal structure was determined by X-ray diffraction method and the polymeric complex crystallizes in the triclinic P-1 space group.

[Herbs for increasing breast-milk production].

Subjective perception of insufficient milk supply is one of the most common problems of nursing mothers. For centuries, herbs have been used to increase lactation and remain popular even today. There is only a limited number of studies proving their safety and effectivity, so their use is based primarily on previous experience.

New silver complexes with bioactive glycine and nicotinamide molecules - Characterization, DNA binding, antimicrobial and anticancer evaluation.

This study introduces a pair of newly synthesized silver complexes, [Ag(HGly)](NO) (1) and [Ag(Nam)]NO·HO (2) (Gly - glycine, Nam - nicotinamide), that were prepared and characterized by relevant methods in solid state (elemental, spectral, thermal and structural analysis) and their stability in solution was verified by H NMR measurements. Moreover, suitable reaction conditions were observed by potentiometry depending on pH in case of binary system Ag-Gly. X-ray analysis confirmed argentophilic interactions in complex 1 with an Ag1-Ag2 distance of 2.