NOTA Complexes with Copper(II) and Divalent Metal Ions: Kinetic and Thermodynamic Studies.

Hnota derivatives are among the most studied macrocyclic ligands and are widely used for metal ion binding in biology and medicine. Despite more than 40 years of chemical research on Hnota, the comprehensive study of its solution chemistry has been overlooked. Thus, the coordination behavior of Hnota with several divalent metal ions was studied in detail with respect to its application as a chelator for copper radioisotopes in medical imaging and therapy.

Nickel induced structural and functional alterations in mouse Leydig cells in vitro.

The present study was aimed at investigating effects of nickel (NiCl(2)) on secretion of testosterone (T), cell viability, ultrastructure and apoptosis in mouse Leydig cells. Testosterone release was measured after 48h of culture with 15.67, 31.