Publications by authors named "Zuzana Ozaniak Strizova"
Article Synopsis
- - Acute cellular rejection (ACR) is common after lung transplants and can lead to chronic lung problems and affect survival rates; diagnosing it can be tricky due to inconsistent interpretations among pathologists.
- - This study explored the use of immunohistochemistry to identify specific markers (like PD-L1 and PECAM-1) in lung tissue samples from lung transplant patients to improve ACR diagnosis.
- - Results showed that PD-L1 levels were higher in patients with ACR, indicating an immune response suppression effort, and there were notable differences in PECAM-1 levels, highlighting these markers’ potential usefulness for detecting ACR.
Background: Chest wall sarcomas are rare and pose significant technical challenges in surgical management, particularly in patients with advanced disease. In this study, we examined the extent of resection, reconstruction techniques, and oncological outcomes of patients with chest wall soft tissue and bone sarcomas.
Methods: This retrospective single-center series included patients who underwent surgery at our center between May 2014 and February 2022 for deep-seated/subfascial primary and recurrent soft tissue or bone sarcomas of the chest wall requiring significant resection and extensive reconstruction.
Article Synopsis
- Prostate cancer (PCa) has an immunosuppressive environment that limits immune activation, resulting in reduced activity of cytotoxic T-cells and increased levels of regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), which are linked to poorer outcomes.
- The review emphasizes the role of different immune cells, including beneficial Th1 and harmful Th17 cells, in influencing tumor behavior, and how PCa's low immunogenicity poses challenges for immunotherapy.
- Chemotherapy is shown to have the potential to enhance the immune response against tumors by transforming the "cold" tumor microenvironment into a "hot" one, improving treatment efficacy by targeting immunosuppressive cells.
Purpose: The IMMUNOSARC trial combined an antiangiogenic agent (sunitinib) with a PD1 inhibitor (nivolumab) in advanced sarcomas. Here, we present the first correlative studies of the soft-tissue sarcoma cohort enrolled in this trial.
Experimental Design: Formalin-fixed paraffin-embedded and peripheral blood samples were collected at baseline and week 13.
Introduction: Compared with traditional static ice storage, controlled hypothermic storage (CHS) at 4-10°C may attenuate cold-induced lung injury between procurement and implantation. In this study, we describe the first European lung transplant (LTx) experience with a portable CHS device.
Methods: A prospective observational study was conducted of all consecutively performed LTx following CHS (11 November 2022 and 31 January 2024) at two European high-volume centers.
Article Synopsis
- The study investigates the role of CD47, a molecule that helps tumor cells evade the immune system, in various soft tissue sarcomas (STS) and its potential as a marker for prognosis.
- Researchers analyzed tumor samples from 55 patients to assess CD47 levels and how they relate to tumor grades and patient survival outcomes.
- Findings showed that CD47 is widely expressed in high-grade undifferentiated pleomorphic sarcomas and other STS subtypes, suggesting it may play a critical role in tumor survival, particularly in higher-grade tumors.
Static ice storage has long been the standard-of-care for lung preservation, although freezing injury limits ischemic time (IT). Controlled hypothermic storage (CHS) at elevated temperature could safely extend IT. This retrospective analysis assesses feasibility and safety of CHS with IT > 15 hours.
View Article and Find Full Text PDFRenal cell carcinoma (RCC) is a common malignancy frequently diagnosed at the metastatic stage. We performed a comprehensive analysis of the tumor immune microenvironment (TIME) in RCC patients, including the peritumoral tissue microenvironment, to characterize the phenotypic patterns and functional characteristics of infiltrating immune cells. T cells from various compartments (peripheral blood, tumor, peritumoral area, and adjacent healthy renal tissue) were assessed using flow cytometry and Luminex analyses, both before and after T cell-specific stimulation, to evaluate activation status and migratory potential.
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