Publications by authors named "Zusen Yuan"
Background: Circular RNAs (circRNAs) have been identified as playing an integral role in the development of bladder cancer (BC). However, the mechanism by which circRNAs operate in the chemical carcinogenesis of BC remains unclear.
Methods: To explore this mechanism, we used RNA high-throughput sequencing to identify differentially expressed circRNA in bladder epithelial cells and chemically induced malignant transformed BC cells.
Background: The posttranscriptional modifications of transfer RNA (tRNA) are critical for all aspects of the tRNA function and have been implicated in the tumourigenesis and progression of many human cancers. By contrast, the biological functions of methyltransferase-like 1 (METTL1)-regulated m G tRNA modification in bladder cancer (BC) remain obscure.
Results: In this research, we show that METTL1 was highly expressed in BC, and its level was correlated with poor patient prognosis.
Background: Accumulating evidence has revealed the critical roles of N-methyladenosine (mA) modification of mRNA in various cancers. However, the biological function and regulation of mA in bladder cancer (BC) are not yet fully understood.
Methods: We performed cell phenotype analysis and established in vivo mouse xenograft models to assess the effects of mA-modified ITGA6 on BC growth and progression.
N6-methyladenosine (mA) is the most abundant internal modification in mammalian mRNAs. Despite its functional importance in various physiological events, the role of mA in chemical carcinogenesis remains largely unknown. Here we profiled the dynamic mA mRNA modification during cellular transformation induced by chemical carcinogens and identified a subset of cell transformation-related, concordantly modulated mA sites.
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