Publications by authors named "Zupeng Luan"
Purpose: This study aims to explore novel biomarkers related to the coagulation process and tumor-associated macrophage (TAM) infiltration in lung adenocarcinoma (LUAD).
Methods: The macrophage M2-related genes were obtained by Weighted Gene Co-expression Network Analysis (WGCNA) in bulk RNA-seq data, while the TAM marker genes were identified by analyzing the scRNA-seq data, and the coagulation-associated genes were obtained from MSigDB and KEGG databases. Survival analysis was performed for the intersectional genes.
Article Synopsis
- The study assessed the impact of 3D conformal thoracic radiotherapy (TRT) combined with chemotherapy on patients with extensive-stage small-cell lung cancer (ES-SCLC).
- A total of 165 patients were analyzed, showing improved overall survival (OS) and progression-free survival (PFS) rates in the group receiving chemotherapy alongside TRT compared to those receiving chemotherapy alone.
- Key findings include a median OS of 15 months and a favorable prognosis associated with receiving at least 4 cycles of chemotherapy and TRT, indicating that TRT enhances treatment outcomes for ES-SCLC patients.