Natural products as inhibitors against pancreatic cancer cell proliferation and invasion: possible mechanisms.

Pancreatic cancer is one of the gastrointestinal tumors with the lowest survival rate and the worst prognosis. At the time of diagnosis, the majority of patients have missed the opportunity for radical surgical resection and opt for chemotherapy as their primary treatment choice. And drug resistance emerges during the application of the most widely used chemotherapeutic regimens such as modified FOLFIRINOX regimen, gemcitabine monotherapy or 5-Fluorouracil combination therapy, which further reduces the therapeutic efficacy.

Energy-Based Approach to Predict Fatigue Life of Asphalt Mixture Using Three-Point Bending Fatigue Test.

The three-point bending fatigue tests were carried out in order to accurately predict the fatigue life of an asphalt mixture based on the plateau value (PV) of the dissipated strain energy ratio (DSER). The relations of the dissipated strain energy (DSE) to the stress-strength ratio, temperature and loading rate were studied, and the constructions of the mathematical models of DSE and DSER were completed based on the change laws of the DSE. The relation of the fatigue life to the PV was determined based on the analysis of damage evolution, based on which the fatigue equation was established and used to predict the fatigue life.