Potential biological roles of exosomal non-coding RNAs in breast cancer.

Breast cancer (BC) is one of the most common malignant tumors among women, accounting for 24.5% of all cancer cases and leading to 15.5% of cancer-related mortality.

Intratumoral Injection of R848 and Poly(I:C) Synergistically Promoted Antitumour Immune Responses by Reprogramming Macrophage Polarization and Activating DCs in Lung Cancer.

Introduction: Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the success of immunotherapy relies on overcoming the immunosuppressive tumour microenvironment, making remodelling this environment a potential strategy for lung cancer therapy. Research suggests that Toll-like receptor (TLR) agonists can impede tumour growth by promoting the conversion of tumour-associated macrophages into an M1-like state or enhancing dendritic cell development.

The clinical significance of T-cell regulation in hypertension treatment.

Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction and elevated blood pressure. The activation of Th1 and Th17 cell subsets, along with the dysfunction of regulatory T cells (Tregs), is a critical mechanism in the onset and progression of hypertension.

Phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in older patients with newly diagnosed acute myeloid leukemia.

Introduction: Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.

Change Fatigue Among Clinical Nurses and Related Factors: A Cross-sectional Study in Public Hospitals.

Objectives: To investigate the levels of change fatigue among clinical nurses in public hospitals and identify the potential contributing factors.

Design: A cross-sectional, multi-stage sampling study was conducted in accordance with the STROBE guideline.

Methods: This study surveyed 2,228 nurses in China from October to December 2023 using Wen Juan Xing (www.

Genomic surveillance of emerging SARS-CoV-2 Omicron variations in Tianjin Municipality, China 2022.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted public health. In 2022, the Omicron variant of SARS-CoV-2 rapidly became the dominant circulating variant in the local COVID-19 outbreaks in Tianjin Municipality, China. To gain a deeper understanding of the genetic variations of the Omicron variant in Tianjin, specimens from individuals who tested positive for SARS-CoV-2 between December 2021 and November 2022 were used for virus whole genome sequencing and phylogenetic analysis.

Artificial Intelligence Screening Tool for Obstructive Sleep Apnoea: A Study Based on Outpatients at a Sleep Medical Centre.

Purpose: Due to the lack of clear screening guidelines for different populations, identify strategies for obstructive sleep apnea (OSA) in the outpatient population are unclear, a large number of potential OSA outpatients have not been identified in time. The purpose of our study was to evaluate the applicability and accuracy of artificial intelligence sleep screening in outpatients and to provide a reference for OSA screening in different populations.

Methods: A type IV wearable artificial intelligence sleep monitoring (AISM) device was used to screen adults in the sleep clinic of the Sleep Medical Center for OSA screening, and the general demographic data of the patients were collected.

Advances and challenges of mpox detection technology.

Mpox is a zoonotic disease caused by the monkeypox virus (MPXV). Diagnosing and treating the disease has become a global health concern requiring close attention to its spread to non-endemic regions. Clinical diagnosis is based on laboratory test results.

A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8 T cell test.

Since the outbreak of the coronavirus disease 2019 (COVID-19) epidemic in 2019, the public health system has faced enormous challenges. Tracking the individuals who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated mortality. With the increasing of asymptomatic infections, it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome sequencing.

Multimodal Metaverse Healthcare: A Collaborative Representation and Adaptive Fusion Approach for Generative Artificial-Intelligence-Driven Diagnosis.

The metaverse enables immersive virtual healthcare environments, presenting opportunities for enhanced care delivery. A key challenge lies in effectively combining multimodal healthcare data and generative artificial intelligence abilities within metaverse-based healthcare applications, which is a problem that needs to be addressed. This paper proposes a novel multimodal learning framework for metaverse healthcare, MMLMH, based on collaborative intra- and intersample representation and adaptive fusion.

Coupling of chromatography with surface-enhanced Raman spectroscopy: trends and prospects.

Surface-enhanced Raman spectroscopy is a powerful analytical technique for the determination of analytes with the advantages of sensitivity, portability, and simplicity, able to provide structural information for the identification of compounds. However, when it comes to the analysis of complex samples, matrix components may interfere with the analyte quantification. To overcome this shortcoming, a number of approaches have been proposed, such as extraction techniques.

Assessment of chest CT abnormalities and pulmonary function at 6-month and 1-year after hospital discharge in Chinese patients of COVID-19 pneumonia at the turn of 2022-2023.

Objective: This study aimed to assess chest CT abnormalities and pulmonary function at 6-month and 1-year follow-ups in coronavirus disease 2019 (COVID-19) pneumonia patients of the China epidemic in the turn of 2022-2023.

Methods: A total of 156 hospitalized patients with COVID-19 pneumonia admitted between 29 November 2022 and 10 February 2023 were prospectively assessed at 6-month and 1-year follow-ups. Characteristics and CT scores of pulmonary abnormalities and pulmonary function were compared between different follow-up time points.

Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis.

Background: The mechanism by which ibrutinib, a Bruton's tyrosine kinase inhibitor, can elevate the risk of arrhythmias is not fully elucidated. In this study, we explored how inhibition of off-target kinases can contribute to this phenomenon.

Methods: We performed a Mendelian randomization analysis to examine the causal associations between genetically proxied inhibition of six putative ibrutinib drug targets (ErbB2/HER2, CSK, JAK3, TEC, BLK, and PLCG2) and the atrial fibrillation (AF) risk, proarrhythmic ECG indices, and cardiometabolic traits and diseases.

Patients with AMA/anti-sp100/anti-gp210 Positivity and Cholestasis Can Manifest Conditions Beyond Primary Biliary Cholangitis.

Background And Aims: The diagnostic value of primary biliary cholangitis (PBC)-specific antibodies in patients with elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels, and other identifiable causes, was unclear. Our study aimed to determine whether etiological treatments in PBC-specific antibody-positive patients could improve liver biochemical tests, thereby distinguishing them from individuals with PBC.

Methods: We enrolled patients who were positive for PBC-specific antibodies and elevated ALP and/or GGT levels but with other identifiable etiologies.

Gadolinium Functionalized Carbon Dot Complexes for Dual-Modal Imaging: Structure, Performance, and Applications.

Gadolinium functionalized carbon dot complexes (Gd-CDs) have both the fluorescent properties of carbon dots and the magnetic characteristics of gadolinium ions, exhibiting excellent biocompatibility, high spatial resolution, high sensitivity, and deep tissue penetration in bioimaging. As fluorescence (FL) and magnetic resonance imaging (MRI) probes, Gd-CDs have attracted significant attention in dual-modal biological imaging. This review summarizes recent advances in Gd-CDs, focusing on their structure, optical and magnetic properties, and applications in dual-modal imaging.

Spray-Dried Inhalable Favipiravir Dry Powder Formulation for Influenza Therapy: Preparation and In vivo Evaluation.

Background: Influenza, a seasonal infectious disease, has consistently posed a formidable challenge to global health in recent years. Favipiravir, an RNA-dependent RNA polymerase inhibitor, serves as an anti-influenza medication, currently administered solely in oral form for clinical use. However, achieving an effective therapeutic outcome often necessitates high oral doses, which can be accompanied by adverse effects and suboptimal patient adherence.

Patterns and Correlates of Bone Mineral Density Parameters Measured Using Calcaneus Quantitative Ultrasound in Chinese Adults.

Monitoring bone mineral density (BMD) in adults is critical for early detection of osteoporosis and prevention of fracture, for which quantitative ultrasound (QUS) is a good non-invasive tool. We examined the associations of QUS measures, including stiffness index (SI) and T-score, with socio-demographic, lifestyle, and anthropometric correlates and risk of subsequent fracture. : Calcaneal QUS was performed using GE's Lunar Achilles EXPII among 24,651 adults (mean age 59.

Application of Phosphogypsum in Ultra-High-Performance Concrete (UHPC) Matrix for Strength Enhancement and Shrinkage Reduction.

Ultra-high-performance concrete is a high-strength and durable material widely used in infrastructure, but its high cement content raises environmental concerns, particularly in terms of CO₂ emissions and resource consumption. Phosphogypsum, an industrial by-product of phosphoric acid production, presents a sustainable alternative by partially replacing cement, thereby reducing cement demand and addressing solid waste disposal issues. This study investigates the effects of PG incorporation (0-40%) on hydration kinetics, mechanical properties, and volume stability in UHPC.

Characteristics of 3D-Integrated GaN Power Module Under Multi Heat Source Coupling.

3D-integrated GaN power modules can effectively reduce parasitic parameters and enhance the power system's performance. However, the heat from each power chip during operation can lead to a mutual thermal coupling effect, potentially causing performance drift of the GaN power chips. This work investigates the impact of the thermal coupling effect in a 3D-integrated GaN power module on the characteristics of its GaN power chips.

Preparation and Photocatalytic Degradation Performance of C@CdMnS to Tetracycline Hydrochloride.

CdMnS solid solutions were synthesized by incorporating Mn into CdS and the optimal ratio of Mn to Cd was explored via photocatalytic degradation performance for tetracycline (TC). Subsequently, the composite catalyst C@CdMnS was prepared by loading CdMnS onto the biomass gasification carbon residue (C) by hydrothermal method and characterized by various characterization tests. The optimal TC photodegradation condition and degradation mechanism catalyzed by C@CdMnS was investigated.

Hydrogen Embrittlement Susceptibility of a Newly Developed Grain-Refined Ultra-High Strength Steel.

The hydrogen embrittlement susceptibility of a newly developed 1700 MPa-grade ultra-high-strength steel with a primary austenite grain size of 4 μm was studied and the mechanical properties and microstructure were characterized. The results show that the hydrogen content in the steel increases with the extension of charging time: the value reached 0.35 wppm with a charging time of 96 h.

Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking.

Alzheimer's disease is a progressive neurodegenerative disorder with limited treatment options. Lingonberry ( L.) has demonstrated neuroprotective and anti-inflammatory properties, yet the underlying mechanisms remain unclear.

Circ_0011446 Regulates Intramuscular Adipocyte Differentiation in Goats via the miR-27a-5p/FAM49B Axis.

Intramuscular fat (IMF), or marbling, is a critical indicator of goat meat quality. Non-coding RNAs play a key role in the formation and deposition of IMF in vertebrates by regulating genes involved in its synthesis, degradation, and transport. The competing endogenous RNA (ceRNA) hypothesis identifies circular RNAs (circRNAs) as natural "sponges" for microRNAs (miRNAs).

Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway.

The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) regulates glucolipid metabolic disorder remains unclear. In this study, we first assessed the effect of VDMY on various physiological parameters in mice, followed by RNA sequencing (RNA-seq) to identify key signaling pathways affected by VDMY in liver tissues.

Inhibition of LncRNA Attenuates Testicular Torsion-Induced Apoptosis and Preserves Blood-Testis Barrier Integrity.

Testicular torsion is a common emergency in adolescents, and can lead to severe ischemia reperfusion injury (IRI). LncRNA has been shown to increase during ischemia, but its role in testicular IRI remains unknown. Focusing on this research gap, we utilized biallelic mutant mice and Sertoli cell line (TM4) to construct in vivo and in vitro models of ischemia/reperfusion (I/R) and oxygen-glucose deprivation/reperfusion (OGD/R).