Publications by authors named "Zuojie Peng"
In recent years, the gut microbiome has gained significant attention in the spheres of research and public health. As a result, studies have increasingly explored the potential of probiotic dietary supplements as treatment interventions for conditions such as anxiety and depression. The present study examined the effect of mixed probiotics (Lacticaseibacillus rhamnosus and Enterococcus faecium) on inflammation, microbiome composition, and depressive-like behaviors in a macaque monkey model.
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- Research shows chronic sleep deprivation can weaken the immune system and potentially contribute to colon cancer development, but the exact connection is not well understood.
- Using a mouse model, this study found that sleep deprivation increases GABA levels, which in turn promotes the growth and spread of colon cancer cells, particularly through interactions with macrophages.
- The findings revealed that GABA activates certain pathways leading to higher stability of a protein called cMYC in colon cancer cells, which enhances their ability to proliferate and migrate, driven by changes in macrophage behavior.
Aim: We screened key angiogenesis-related lncRNAs based on colon adenocarcinoma (COAD) to construct a RiskScore model for predicting COAD prognosis and help reveal the pathogenesis of the COAD as well as optimize clinical treatment.
Background: Regulatory roles of lncRNAs in tumor progression and prognosis have been confirmed, but few studies have probed into the role of angiogenesis-related lncRNAs in COAD.
Objective: To identify key angiogenesis-related lncRNAs and build a RiskScore model to predict the survival probability of COAD patients and help optimize clinical treatment.
Accurately predicting survival in patients with early hepatocellular carcinoma (HCC) is essential for making informed decisions about treatment and prognosis. Herein, we have developed a machine learning (ML) model that can predict patient survival and guide treatment decisions. We obtained patient demographic information, tumor characteristics, and treatment details from the SEER database.
View Article and Find Full Text PDFBackground: Identifying effective immunosuppressive strategies is critical for addressing immunological rejection following organ transplantation. This study explores the potential immunosuppressive effects and mechanisms of temsirolimus, a rapamycin derivative, in organ transplantation.
Methods: A mouse cardiac allograft model was established using a cervical cannula technique with BALB/c donors and C57BL/6 recipients.