The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3.

Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis.

IP-10/CXCR3 Axis Promotes the Proliferation of Vascular Smooth Muscle Cells through ERK1/2/CREB Signaling Pathway.

Excessive proliferation of vascular smooth muscle cells is one of the main pathological processes leading to atherosclerosis and intimal hyperplasia after vascular interventional therapy. Our previous study has shown that interferon-γ inducible protein-10 contributes to the proliferation of vascular smooth muscle cell. However, the underlying mechanisms remain unclear.

The in vivo performance of small-caliber nanofibrous polyurethane vascular grafts.

Background: In a previous in vitro study, we confirmed that small-caliber nanofibrous polyurethane (PU) vascular grafts have favorable mechanical properties and biocompatibility. In the present study, we examined the in vivo biocompatibility and stability of these grafts.

Methods: Forty-eight adult male beagle dogs were randomly divided into two groups receiving, respectively, polyurethane (PU) or polytetrafluoroethylene (PTFE) grafts (n = 24 animals / group).

Promising plasmid DNA vector based on APTES-modified silica nanoparticles.

Nanoparticles have an enormous potential for development in biomedical applications, such as gene or drug delivery. We developed and characterized aminopropyltriethoxysilane-functionalized silicon dioxide nanoparticles (APTES-SiNPs) for gene therapy. Lipofectamine(®) 2000, a commonly used agent, served as a contrast.

[Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis].

Objective: To develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility.

Methods: The effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber (4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties. The mechanical properties and biocompatibility of the prepared grafts were evaluated.

[Risk factors and therapeutic strategies of deep venous thrombosis during pregnancy].

Objective: To summarize the epidemiology and risk factors of deep venous thrombosis (DVT) during pregnancy and develop therapeutic strategies.

Methods: Twenty-nine pregnant women with DVT were admitted into our hospital between 1991 and 2010. And their clinical data were retrospectively reviewed.

Tolerable hemodynamic changes after femoral artery ligation for the treatment of infected femoral artery pseudoaneurysm.

Background: We analyzed the hemodynamic changes induced by femoral artery ligation with concomitant thrombectomy in intravenous drug abusers with infected femoral artery pseudoaneurysm (IFAP) and their clinical significance.

Methods: Between January 2000 and November 2007, a total of 55 patients presented to our clinic with IFAP. Among these patients, 54 were treated by femoral artery ligation with concomitant thrombectomy.

[Experience of surgical treatment of carotid body tumor after preoperative embolization of feeding vessels].

Objective: To evaluate the effect of preoperative embolization of the feeding vessels of carotid body tumor in the treatment thereof.

Methods: 33 patients with carotid body tumors not less than 3 cm in diameter were examined by color Doppler ultrasound. Polyvinyl alcohol particle 250-1000 microm in diameter were suspended in meglumine diatrizoate or Ultravist and then injected via microcatheter into the feeding vessels until detainment or reflux was seen.

Stent-grafting for unfavorable abdominal aortic aneurysm: a practical challenge.

Background: The endovascular treatment of abdominal aortic aneurysm (AAA) has improved greatly in the last 15 years. The present study aimed to evaluate the endografting experience for the treatment of unfavorable abdominal aortic aneurysm (uAAA).

Methods: During December 2001 and December 2007, 41 patients with uAAA were treated with endografting using concomitant techniques.

Effects of antiatherosclerosis in carotid artery by RNAi-mediated silencing of MCP-1 expression.

Background: Our objective was to identify the effects of MCP-1 siRNA in vivo transfection in an atherosclerosis model on local expression of MCP-1 and pathogenesis of atherosclerosis.

Methods: Carotid atherosclerosis was induced in 28 New Zealand white rabbits. Rabbits were divided into three groups randomly: RNAi group, model group, and blank plasmid group.

[Early to mid-term results of endovascular repair of aortic dissection: report of 165 cases].

Objective: To evaluate the early and midterm outcomes of endovascular repair of aortic dissection (AD).

Methods: Between January 2001 and December 2006, 165 patients (145 male and 20 female) with AD were treated with endovascular repairing. The mean age of the patients was 52.

[Endovascular stent-graft repair for Stanford type A aortic dissection with extra-anatomic bypass].

Unlabelled: OBJECTIVE To evaluate the effects of endovascular stent-graft repair for Stanford type A aortic dissection combined with extra-anatomic bypass.

Methods: To perform endovascular repair for Stanford type A aortic dissection, we tried to extend the landing zone by extra-anatomic bypass to reconstruct the innominate artery, the left common carotid artery or the left subclavian artery, and then achieved the process immediately or at a secondary stage via either the carotid or the femoral approach.

Results: Thirty-four patients with ascending aortic dissection (n=8) and aortic arch dissection (n=26) were treated with this technique.

[Endovascular stent-graft treatment for DeBakey I aortic dissection].

Objective: To study endovascular treatment of DeBakey type I aortic dissecting aneurysm.

Methods: Seven patients with DeBakey I aortic dissecting aneurysms were treated. Diagnoses were confirmed by MRA, CT and angiography.

Effect of external valvuloplasty of the deep vein in the treatment of chronic venous insufficiency of the lower extremity.

Objective: This study was conducted to verify the efficacy of external valvuloplasty of the femoral vein in the treatment of primary chronic venous insufficiency (PCVI).

Methods: Forty patients with PCVI of the bilateral lower extremities were enrolled at the time of surgical management. All 80 limbs were classified as CEAP C2 to C4, with moderate incompetence of the deep vein.

[Endovascular stent-graft exclusion of giant and long-segment thoracic aortic aneurysms].

Objective: To discuss the availability of endovascular stent-graft exclusion in giant and long-segment thoracic aortic aneurysms.

Methods: Endovascular stent-graft exclusion was performed on 3 male patients with giant and long-segment thoracic aortic aneurysm. Multiple stent-grafts were connected as a long stent-graft to repair these thoracic aortic aneurysms, of which one with 28 cm in length and 7.

[Single or staged endovascular stent-graft repair for aortic dissection with multi-tears].

Objective: To evaluate the single or staged endovascular stent-graft repair for aortic dissection with multi-tears.

Methods: The stent-grafts were inserted through the femoral artery to seal the tears of dissection.

Results: Between January 2001 and June 2004, 8 patients with aortic dissection underwent stent-graft placement.

[Effect of external vavuloplasty of deep vein in the treatment of chronic venous insufficiency of lower extremity].

Objective: To verify the role and effect of external vavuloplasty in the treatment of chronic venous insufficiency (CVI) of lower extremity.

Methods: Thirty patients with CVI of bilateral lower extremities were enrolled to accept surgical management of vein systems. Both limbs of each patient were randomized into two groups respectively according to the operating style.

[Endografting for refractory aortic dissection and dissecting aneurysm].

Objective: To explore the safety and feasibility of endograft repair in refractory aortic dissection and dissecting aneurysm.

Methods: The clinical data of 13 refractory cases of aortic dissection and dissecting aneurysm, 11 males and 2 females, aged 52 (38-82), out of the 68 consecutive patients with aortic dissection and dissecting aneurysm who underwent endograft repair from Jan 2001 to Oct 2004, were analyzed. Nine of the 13 cases were diagnoses as with aortic dissection and dissecting aneurysm of Stanford type A, 3 of which had tears in the ascending aorta (DeBakey type I), 3 had tears in aortic arch, and 3 had tears on the distal aortic arch with ascending aorta involved; and the other four out of the 13 cases were diagnosed as Stanford type B, one with Marfan's syndrome.

[Endovascular stent-graft exclusion on aortic dissection and dissecting aneurysm].

Objective: To study the techniques and therapeutic effects of endovascular stent-graft exclusion in aortic dissection and dissecting aneurysm.

Methods: The clinical data of 20 cases with aortic dissection and(or) dissecting aneurysm were analysed. Stanford A dissection was found in 2 cases, in which one had a tear entry on ascending aorta.

[Default of KIAA0353 gene in varicose great saphenous vein accompanying primary deep vein valve insufficiency].

Objective: To screen and identify the genes related to the occurrence and development of varicose great saphenous vein in the patients with primary deep vein valve insufficiency (PDVI).

Methods: mRNA fluorescent differential display (FDD) technique was used to compare the different cDNA fragments originated from differentially expressed mRNAs from the venous tissues of 10 patients with varicose great saphenous vein complicated with PDVI. Ten specimens of normal venous tissue from 10 patients dying from other diseases were used as controls.

Quantitative assessment of the degree of deep venous reflux of the lower extremities.

Objective: We sought to quantitatively evaluate the degree of deep venous reflux of the lower extremities using colour Doppler velocity profile (CDVP) technology.

Methods: Deep venous reflux volume was examined using CDVP in 79 limbs of 66 patients who were admitted to our hospital between July 1999 and July 2000 with primary, deep venous, valvular incompetence. Reflux data were statistically described and analyzed.