Publications by authors named "Zuo-Hua Yu"
Aim: Pirfenidone (PFD) has been used as medication for idiopathic pulmonary fibrosis due to its ability in reducing lung fibrosis. However, the underlying mode of action in renal fibrosis during chronic renal allograft dysfunction (CRAD) requires further investigation. Therefore, the present study was conducted to explore the effects of PFD on renal injury induced by CRAD.
View Article and Find Full Text PDFRenal interstitial fibrosis (RIF) is a common manifestation of inflammatory and noninflammatory renal diseases, which correlates to renal excretory dysfunction. Recently, the long noncoding RNAs (lncRNAs) have been demonstrated to be involved in the development of various renal diseases. Here, we aim to determine whether paeonol (PAE) affects RIF with involvement of the lncRNA HOX transcript antisense intergenic RNA (HOTAIR)/microRNA-124 (miR-124)/Notch1 axis.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates how the long non-coding RNA (LncRNA) HOTAIR impacts renal interstitial fibrosis (RIF) by regulating the Notch1 pathway through miR-124 modulation.
- - The researchers used a rat model and HK-2 cell experiments to compare different treatment groups, measuring expressions of HOTAIR, miR-124, Notch1, and proteins related to epithelial-to-mesenchymal transition (EMT).
- - Results showed that silencing HOTAIR enhanced miR-124 levels, inhibited the Notch1 pathway, decreased key fibrosis-related proteins, and reduced EMT, highlighting HOTAIR's potential as a target for RIF treatment.