Publications by authors named "Zuo Wang"

Aim: Pyroptosis is a type of programmed cell death characterized by pro-inflammatory activity and is an important factor in pre-eclampsia (PE). Trimethylamine N-oxide (TMAO) is a gut microbial metabolite closely associated with pyroptosis and PE. This study aims to investigate the role of TMAO in trophoblast cell pyroptosis and explore possible mechanisms.

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A key property of the circadian clock is that it is reset by light to remain synchronized with the day-night cycle. An attractive model to explore light input to the circadian clock in vertebrates is the zebrafish. Circadian clocks in zebrafish peripheral tissues and even zebrafish-derived cell lines are entrainable by direct light exposure thus providing unique insight into the function and evolution of light regulatory pathways.

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The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has risen sharply. This condition is strongly associated with the risk of cardiovascular disease (CVD), but how MAFLD affects the development and progression of CVD, particularly concerning vascular calcification, remains unclear. Herein, extracellular vesicles (EVs) are identified from steatotic hepatocytes as a trigger that accelerated the progression of both vascular intimal and medial calcification.

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  • The study aimed to create a pharmacokinetic model for the antibiotic ceftazidime specifically for critically ill children in the pediatric intensive care unit (PICU) and to determine optimal dosing regimens for this group.
  • A prospective study was conducted with 88 children, using statistical methods and Monte Carlo simulations to evaluate dosing that maintains effective drug levels against bacterial infections.
  • The final model suggested individualized dosing based on weight and kidney function, achieving high effectiveness for common MICs but indicating the need for higher doses when dealing with more resistant infections.
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  • - This study examined how supplementing beef cattle diets with L-Leucine (L-Leu) affects growth, blood amino acid levels, and meat quality, using 24 Angus cows divided into two groups for 120 days.
  • - Results showed that L-Leu supplementation led to higher daily weight gain, better feed efficiency, and increased protein in both plasma and longissimus thoracis muscle, while also modifying the levels of several amino acids.
  • - The supplementation resulted in improved meat quality indicators such as marbling and reduced fat thickness, suggesting that L-Leu enhances overall beef quality by influencing metabolic processes.
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Antiviral drugs are widely used, yet their potential risks during early development, particularly within the central nervous system, remain contentious. Oseltamivir phosphate (OSE), a commonly prescribed antiviral, is increasingly detected in various environments. However, its toxicity to organisms and the underlying mechanisms are not well understood.

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Cardiovascular and cerebrovascular diseases (CCVDs) significantly contribute to global mortality and morbidity due to their complex pathogenesis involving multiple biological processes. Ferroptosis is an important physiological process in CCVDs, manifested by an abnormal increase in intracellular iron concentration. MiRNAs, a key class of noncoding RNA molecules, are crucial in regulating CCVDs through pathways like glutathione-glutathione peroxidase 4, glutamate/cystine transport, iron metabolism, lipid metabolism, and other oxidative stress pathways.

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  • The study investigates the link between gut microbiota dysbiosis, intestinal inflammation, and glaucoma, focusing on fecal markers of inflammation and permeability.
  • Researchers compared fecal lactoferrin (Lf) and alpha-1 antitrypsin (AAT) levels between 114 glaucoma patients and 75 healthy controls, finding elevated levels in glaucoma patients.
  • Results indicate that higher levels of these fecal biomarkers correlate with greater glaucoma severity, suggesting that increased intestinal inflammation and permeability may play a role in the condition.
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Introduction: Hyperglycemia is closely related to trophoblast dysfunction during pregnancy and results in suppressed invasion, migration, and pro-inflammatory cell death of trophoblasts. Hyperglycemia is a dependent risk factor for gestational hypertension accompanied by decreased placental growth factor (PLGF), which is important for maternal and fetal development. However, there is currently a lack of evidence to support whether PLGF can alleviate trophoblast cell dysfunction caused by high blood sugar.

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  • * Results showed that glaucoma patients had significantly higher plasma AAT levels compared to healthy individuals (p < 0.001).
  • * Higher plasma AAT levels were associated with more severe stages of the disease, and it proved to be a useful biomarker for distinguishing early glaucoma from advanced cases.
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The motility pattern of the reticulo-rumen is a key factor affecting feed intake, rumen digesta residence time, and rumen fermentation. However, it is difficult to study reticulo-ruminal motility using general methods owing to the complexity of the reticulo-ruminal structure. Thus, we aimed to develop a technique to demonstrate the reticulo-ruminal motility pattern in static goats.

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Background: Zellweger Syndrome (ZS), or cerebrohepatorenal syndrome, is a rare disorder due to PEX gene mutations affecting peroxisome function. While PEX6 coding mutations are known to cause ZS, the impact of noncoding mutations is less clear.

Methods: A Chinese neonate and his family were subjected to whole exome sequencing (WES) and bioinformatics to assess variant pathogenicity.

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Background And Objective: Bleeding following endoscopic variceal ligation (EVL) may occur as a result of numerous factors, including a diameter of esophageal varices (EV) that is too large to be completely ligated. The present study aimed to develop an artificial intelligence-based endoscopic virtual ruler (EVR) to measure the diameter of EV with a view to finding more suitable cases for EVL.

Methods: The present study was a multicenter retrospective study that included a total of 1,062 EVLs in 727 patients with liver cirrhosis with EV, who underwent EVL from April 2016 to March 2023.

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Objective: To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing the clinical utility of Lf in glaucoma.

Methods: A cross-sectional study involved 161 glaucoma patients and 115 healthy controls, with a follow-up of 14 subjects after approximately 2 years. Plasma Lf markers were quantified using ELISA, comparing levels between glaucoma patients and healthy controls, and analyzing plasma Lf across different glaucoma severity grades.

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Pyroptosis, a programmed cell death marked by lytic and inflammatory characteristics, plays a crucial role in non‑infectious inflammation‑related diseases but can lead to detrimental outcomes when dysregulated. Stem cells have emerged as key players in modulating pyroptosis through paracrine signaling, offering a novel avenue for tissue repair and regeneration. The present review delved into previous studies elucidating the intricate interplay between stem cells and pyroptosis, emphasizing the potential of stem cell‑based therapies in regulating pyroptotic pathways.

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Introduction: Excessive intake of lactate caused by improper use of silage in animal husbandry has adverse effects on rumen fermentation, such as rumen acidosis. The speed of absorption and metabolism of -lactate in rumen epithelial cells was slower than that of -lactate, making -lactate more prone to accumulate and induce rumen acidosis. Therefore, this study was conducted to explore the effects of dietary -lactate levels on rumen fermentation of beef cattle and its mechanism in an system.

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Background: The cultivation of bananas encounters substantial obstacles, particularly due to the detrimental effects of cold stress on their growth and productivity. A potential remedy that has gained attention is the utilization of ethyl mesylate (EMS)-induced mutagenesis technology, which enables the creation of a genetically varied group of banana mutants. This complex procedure entails subjecting the mutants to further stress screening utilizing L-Hyp in order to identify those exhibiting improved resistance to cold.

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Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical significance, the underlying mechanisms of glaucoma pathogenesis remain poorly understood. In this study, we aimed to unravel the multifaceted nature of glaucoma by investigating the interaction between T cells and retinas.

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  • This study compared the effects of rumen-protected leucine (RP-Leu) and unprotected leucine (RU-Leu) on fermentation parameters and bacterial composition in the rumen of beef cattle.
  • The results showed that RP-Leu had a higher rumen protection rate and was more stable than RU-Leu, which degraded more slowly during the incubation.
  • Meanwhile, RU-Leu enhanced gas production, microbial crude protein synthesis, and branched-chain fatty acids, making it more beneficial for regulating rumen fermentation compared to RP-Leu.
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Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be tackled due to the ill-defined molecular mechanisms. Regardless of the type of VC, it does not depend on a single cell but involves multi-cells/organs to form a complex cellular communication network through the vascular microenvironment to participate in the occurrence and development of VC. Therefore, focusing only on the direct effect of pathological factors on vascular smooth muscle cells (VSMCs) tends to overlook the combined effect of other cells and VSMCs, including VSMCs-VSMCs, ECs-VMSCs, Macrophages-VSMCs, etc.

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The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay.

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Glaucoma is the leading cause of irreversible blindness. Currently, most therapeutic strategies aim to reduce elevated intraocular pressure (EIOP), but this does not always halt disease progression. Evidence suggests a role for T cells in glaucoma pathogenesis, but the underlying mechanisms remain largely unknown.

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In endemic areas, EBV DNA is used to guide diagnosis, detect recurrence and distant metastasis of NPC. Until now, the importance of EBV DNA in the prediction of NPC has received little attention in non-endemic regions. To explore the prognostic value of EBV DNA alone or in combination with PNI in NPC patients from a non-endemic area of China.

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The purpose of this study is to reveal the effects of different particle sizes of rice straw on the rumen protozoa count, nutrient disappearance rate, rumen fermentation, and microbial community in a rumen simulation technique (RUSITEC) system. In this experiment, a single-factor random trial design was adopted. According to the different particle sizes of rice straw, there were three treatments with three replies in each treatment.

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