Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic target.

Background: Colon adenocarcinoma (COAD) is a malignancy with a high mortality rate and complex biological characteristics and heterogeneity, which poses challenges for clinical treatment. Anoikis is a type of programmed cell death that occurs when cells lose their attachment to the extracellular matrix (ECM), and it plays a crucial role in tumor metastasis. However, the specific biological link between anoikis and COAD, as well as its mechanisms in tumor progression, remains unclear, making it a potential new direction for therapeutic strategy research.

Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.

Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear.

Constructing new-generation ion exchange membranes under confinement regime.

Ion exchange membranes (IEMs) enable fast and selective ion transport and the partition of electrode reactions, playing an important role in the fields of precise ion separation, renewable energy storage and conversion, and clean energy production. Traditional IEMs form ion channels at the nanometer-scale via the assembly of flexible polymeric chains, which are trapped in the permeability/conductivity and selectivity trade-off dilemma due to a high swelling propensity. New-generation IEMs have shown great potential to break this intrinsic limitation by using microporous framework channels for ion transport under a confinement regime.

Dynamic Methane Emissions from China's Fossil-Fuel and Food Systems: Socioeconomic Drivers and Policy Optimization Strategies.

In response to the 2023 "Action Plan for Methane Emission Control" in China, which mandates precise methane (CH) emission accounting, we developed a dynamic model to estimate CH emissions from fossil-fuel and food systems in China for the period 1990-2020. We also analyzed their socioeconomic drivers through the Logarithmic Mean Divisia Index (LMDI) model. Our analysis revealed an accelerated emission increase (850.

Adjusting Hirshfeld charge of TEMPO catholytes for stable all-organic aqueous redox flow batteries.

2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives are typical catholytes in aqueous organic redox flow batteries (AORFBs), but reported lifetime of them is limited. We find that the increase of Hirshfeld charge decreases the Gibbs free energy change (ΔG) values of side reactions of TEMPO, a near-linear relationship, and then exacerbates their degradation. Here we predict and synthesize a TEMPO derivative, namely TPP-TEMPO, by analyzing the Hirshfeld charge.

Ultralow k covalent organic frameworks enabling high fidelity signal transmission and high temperature electromechanical sensing.

As integrated circuits have developed towards the direction of complexity and miniaturization, there is an urgent need for low dielectric constant materials to effectively realize high-fidelity signal transmission. However, there remains a challenge to achieve ultralow dielectric constant and ultralow dielectric loss over a wide temperature range, not to mention having excellent thermal conductivity and processability concurrently. We herein prepare dual-linker freestanding covalent organic framework films with tailorable fluorine content via interfacial polymerization.

Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown.

A Modification of the Ostergren Model for Thermomechanical Fatigue Life Prediction of Die-Casting Die Steel.

The Ostergren model is simple in form and widely used in engineering practice, also serving as the modeling basis of both the damage differentiation and crack propagation models. However, the shortcomings of the Ostergren model are that the modeling process is affected by thermomechanical fatigue (TMF) test parameters. To establish a TMF life normalized model, a modified Ostergren model based on hysteresis energy damage and TMF data for H13 steel was proposed.

Metasurface with all-optical tunability for spatially-resolved and multilevel thermal radiation.

Manipulating the thermal emission in the infrared (IR) range significantly impacts both fundamental scientific research and various technological applications, including IR thermal camouflage, information encryption, and radiative cooling. While prior research has put forth numerous materials and structures for these objectives, the significant challenge lies in attaining spatially resolved and dynamically multilevel control over their thermal emissions. In this study, a one-step ultrafast laser writing technique is experimentally demonstrated to achieve position-selective control over thermal emission based on the phase-change material GeSbTe (GST).

Flow field design and visualization for flow-through type aqueous organic redox flow batteries.

Aqueous organic redox flow batteries (AORFBs), which exploit the reversible redox reactions of water-soluble organic electrolytes to store electricity, have emerged as a promising electrochemical energy storage technology. Organic electrolytes possess fast electron-transfer rates that are two or three orders of magnitude faster than those of their inorganic or organometallic counterparts; therefore, their performance at the electrode is limited by mass transport. Direct adoption of conventional cell stacks with flow fields designed for inorganic electrolytes may compromise AORFB performance owing to severe cell polarization.

Cooperation resonance based on link strategy reinforcement learning and conformity.

We propose a game model that integrates reinforcement learning (RL) with link strategies and conformity behavior to investigate the emergence and maintenance of cooperation. The model operates on a lattice network with periodic boundaries and includes two types of nodes: RL nodes with link strategies and conformist nodes. Simulation results reveal a range of critical mass.

A Novel Adaptive Sand Cat Swarm Optimization Algorithm for Feature Selection and Global Optimization.

Feature selection (FS) constitutes a critical stage within the realms of machine learning and data mining, with the objective of eliminating irrelevant features while guaranteeing model accuracy. Nevertheless, in datasets featuring a multitude of features, choosing the optimal feature poses a significant challenge. This study presents an enhanced Sand Cat Swarm Optimization algorithm (MSCSO) to improve the feature selection process, augmenting the algorithm's global search capacity and convergence rate via multiple innovative strategies.

Two-Step Chemical Vapor Deposition for Fabrication of FAPbI Single-Crystal Microsheets with High Exciton Binding Energy.

Hybrid perovskites exhibit highly efficient optoelectronic properties and find widespread applications in areas such as solar cells, light-emitting diodes, photodetectors, and lasers. Here, we report the innovative synthesis of formamidinium lead iodide (FAPbI) single-crystal microsheets via a two-step chemical vapor deposition (CVD) method. The microsheets exhibit hexagonal and trapezoidal shapes, with hexagonal FAPbI growing parallel to the substrate and trapezoidal FAPbI growing perpendicular to the substrate.

Spatial Confinement Growth Enabling MoS@Hollow Mesoporous Carbon Spheres Microspheres with Enhanced Microwave Absorption and Corrosion Resistance.

The complex electromagnetic applications in harsh corrosive environments urgently require research into multifunctional microwave absorption (MA) materials. The core-shell structure is an effective strategy to prepare multifunctional MA materials by efficiently combining the advantages of each component. Nevertheless, it remains a tough challenge to elucidate the effect of the binding positions of each component in MA materials on the comprehensive electromagnetic performance.

Engineering a high-capacity and long-cycle-life magnesium/lithium hybrid-ion battery using a lamellar SnSe/SnSe/SnO cathode.

Since the safety and costs of current lithium-ion batteries are non-ideal, engineering a new energy-storage systems is needed. Magnesium/lithium hybrid-ion batteries (MLHBs) combining fast kinetics of Li ions and a dendrite-free Mg anode are promising. Here, we describe our development of an MLHB using lamellar SnSe/SnSe/SnO as cathode material and an all-phenyl complex (APC)-based electrolyte.

High-Energy LiNiO Li Metal Batteries Enabled by Hybrid Electrolyte Consisting of Ionic Liquid and Weakly Solvating Fluorinated Ether.

In pursuit of the highest possible energy density, researchers shift their focus to the ultimate anode material, lithium metal (Li), and high-capacity cathode materials with high nickel content (Ni > 80%). The combination of these aggressive electrodes presents unprecedented challenges to the electrolyte. Here, we report a hybrid electrolyte consisting of a highly fluorinated ionic liquid and a weakly solvating fluorinated ether, whose hybridization structure enables the reversible operation of a battery chemistry based on Li and LiNiO (Ni = 100%), delivering nearly theoretical capacity of the latter (up to 249 mAh g) for >300 cycles with retention of 78.

Study on the correlation between the number of mushroom poisoning cases and meteorological factors based on the generalized additive model in Guizhou Province, 2023.

Background: Mushroom poisoning is a significant food safety issue in Guizhou Province, China. Studies on this topic are essential for its prevention and control. We aimed to analyze the epidemiological characteristics of mushroom poisoning and study the correlation between its cases and meteorological factors in Guizhou Province.

Paper-Based Microfluidic Device for Extracellular Lactate Detection.

Lactate is a critical regulatory factor secreted by tumors, influencing tumor development, metastasis, and clinical prognosis. Precise analysis of tumor-cell-secreted lactate is pivotal for early cancer diagnosis. This study describes a paper-based microfluidic chip to enable the detection of lactate levels secreted externally by living cells.

Supermolecule-Opitimized Defect Engineering of Rich Nitrogen-Doped Porous Carbons for Advanced Zinc-Ion Hybrid Capacitors.

Pitch-based porous carbons with adjustable surface chemical property and controllable pore structure are regarded as promising cathode materials for aqueous zinc-ion hybrid capacitors (ZIHCs), while its disordered carbon matrix and microstructure as well as insufficient surface defects often result in low Zn-storage capacity and poor rate capability of ZIHCs. Herein, a synergetic strategy of self-assembled supermolecule and enriched defective carbon engineering was developed to achieve ultrahigh edge-nitrogen doping for ZIHCs. The crystallite defects and surface structure of porous carbon could be effectively achieved through grafting electronegative oxygen-containing small molecules and high-level nitrogen-containing functional groups between modified polycyclic aromatic hydrocarbon and supermolecule framework.

The association between weight-adjusted waist circumference index and cardiovascular disease and mortality in patients with diabetes.

Cardiovascular disease (CVD) is a significant health concern, particularly among patients with diabetes. The weight-adjusted waist circumference index (WWI), a novel metric that accounts for central obesity, has shown potential in predicting obesity-related health risks. This study aimed to evaluate the association of WWI with CVD and mortality in patients with diabetes.

Anti-Swelling Microporous Membrane for High-Capacity and Long-Life Zn-I Batteries.

Zinc-iodine (Zn-I) batteries are gaining popularity due to cost-effectiveness and ease of manufacturing. However, challenges like polyiodide shuttle effect and Zn dendrite growth hinder their practical application. Here, we report a cation exchange membrane to simultaneously prevent the polyiodide shuttle effect and regulate Zn deposition.

Association of weight-adjusted waist index with cardiovascular disease and mortality among metabolic syndrome population.

Metabolic syndrome (MetS) is prevalent and significantly impacts global public health, with obesity being a major risk factor for cardiovascular diseases (CVD) and mortality. Traditional metrics like body mass index (BMI) have limitations in assessing obesity-related risks. The weight-adjusted waist circumference index (WWI) has emerged as a novel obesity metric, this study aimed to evaluate the association of WWI with CVD and mortality in MetS patients.

Underwater quantitative thickness mapping through marine growth for corrosion measurement using shear wave EMAT with high lift-off performance.

Underwater inspection is important to ensure the safety, integrity and functionality of underwater structures. Although numerous conventional methods have been adopted for underwater inspection, successful application of most methods relies on the surface condition of the object, which, however, is typically covered by marine growth. Consequently, routine inspection requires thorough cleaning of marine growth, which is time-consuming and costly.

Ultra-Wide Interlayered WMoS Alloy Electrode Patterning through High-Precision Controllable Photonic-Synthesis.

Ultra-thin 2D materials have great potential as electrodes for micro-supercapacitors (MSCs) because of their facile ion transport channels. Here, a high-precision controllable photonic-synthesis strategy that provided 1 inch wafer-scale ultra-thin film arrays of alloyed WMoS with sulfur vacancies and expanded interlayer (13.2 Å, twice of 2H MoS) is reported.

Dual Modification Strategy for Enhanced Cycling and Rate Performance of Ni-Rich Cathode Materials in Lithium-Ion Batteries.

A great challenge in the commercialization process of layered Ni-rich cathode material LiNiCoMnO (NCM, x ≥ 80%) for lithium-ion batteries is the surface instability, which is exacerbated by the increase in nickel content. The high surface alkalinity and unavoidable cathode/electrolyte interface side reactions result in significant decrease for the capacity of NCM material. Surface coating and doping are common and effective ways to improve the electrochemical performance of Ni-rich cathode material.