Perfusion parameters of intravoxel incoherent motion based on tumor edge region of interest in cervical cancer: evaluation of differentiation and correlation with dynamic contrast-enhanced MRI.

Background: Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) is a functional magnetic resonance imaging (MRI) sequence.

Purpose: To evaluate the value of perfusion parameters derived from IVIM-DWI based on tumor edge region of interest (ROI) in differentiation in cervical cancer and investigate the relationship between IVIM and dynamic contrast-enhanced MRI (DCE-MRI).

Material And Methods: Thirty-three patients with pathologically diagnosed squamous cell carcinoma who underwent IVIM-DWI (nine b-values: 1-1000 s/mm) and DCE-MRI were retrospectively assessed in this study.

One-Pot Synthesis of Renewable Phthalic Anhydride from 5-Hydroxymethfurfural by using MoO /Cu(NO ) as Catalyst.

Herein, a synthetic pathway to renewable phthalic anhydride (PA) from 5-hydroxymethfurfural (HMF) in one pot is reported. The commonly available catalysts MoO and Cu(NO ) play a crucial role in integrating the multiple steps of the reaction, namely decarbonylation of HMF to active furyl intermediate (AFI), oxidation of HMF to maleic anhydride (MA), Diels-Alder cycloaddition of AFI and MA, and subsequent dehydration, in one pot. Under mild reaction conditions, a 63.

Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer.

Endometrial cancer (EC) is deemed to be the most typical gynecologic malignant tumor. Despite the incidence of EC being lower in Asia than that in western countries, substantial increased incidence has been observed in the past few decades in Asia. Although various molecular testing methods and genomic science have developed, the overall prognosis is still disappointing.

Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study.

Background: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a "real-world" cohort of pregnant Chinese women with no prior history of venous thromboembolism.

Methods: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016.

A novel nomogram to predict the local tumor progression after microwave ablation in patients with early-stage hepatocellular carcinoma: A tool in prediction of successful ablation.

Objectives: To develop a nomogram for the local tumor progression (LTP) in patients with early-stage hepatocellular carcinoma (HCC) after computed tomography-guided percutaneous microwave ablation (CT-PMWA) and to assess clinical-pathologic risk factors for individual LTP estimation. Furthermore, we compared the prognostic predictive ability for LTP between the nomogram and the traditional staging systems.

Methods: This retrospective study was approved by the institutional review board.

A Supramolecular Artificial Light-Harvesting System with Two-Step Sequential Energy Transfer for Photochemical Catalysis.

An artificial light-harvesting system with sequential energy-transfer process was fabricated based on a supramolecular strategy. Self-assembled from the host-guest complex formed by water-soluble pillar[5]arene (WP5), a bola-type tetraphenylethylene-functionalized dialkyl ammonium derivative (TPEDA), and two fluorescent dyes, Eosin Y (ESY) and Nile Red (NiR), the supramolecular vesicles achieve efficient energy transfer from the AIE guest TPEDA to ESY. ESY can function as a relay to further transfer the energy to the second acceptor NiR and realize a two-step sequential energy-transfer process with good efficiency.

The Antecedents and Consequences of Health Care Professional-Patient Online Interactions: Systematic Review.

Background: Online health care services effectively supplement traditional medical treatment. The development of online health care services depends on sustained interactions between health care professionals (HCPs) and patients. Therefore, it is necessary to understand the demands and gains of health care stakeholders in HCP-patient online interactions and determine an agenda for future work.

Superselective transcatheter arterial embolization to control renal hemorrhage after partial nephrectomy for renal tumors: A report of 9 cases and a literature review.

Objective: This study aimed to evaluate the efficacy and safety of selective arterial embolization for hemorrhage after renal surgery and to summarize the clinical experience.

Materials And Methods: A total of 9 patients underwent arterial embolization after partial nephrectomy from 2010 to 2018.

Results: Technical success was achieved in all patients; however, 3 patients underwent a secondary arterial embolization because of short-term re-hemorrhage or the co-occurrence of accessory renal arterial hemorrhage.

[Effects of Bruton's tyrosine kinase on the proliferation and differentiation of osteoclasts].

Objective: To observe the effect of Bruton's tyrosine kinase (BTK) on the proliferation and differentiation of osteoclasts and to explore the mechanism of BTK on bone destruction in periapical periodontitis.

Methods: After RAW264.7 cells induced with 100 ng·L⁻¹ receptor activator for nuclear factor-κB ligand (RANKL) for 5 days, osteoclast induction was confirmed by light microscopy, tartrate-resistant acid phosphatase (TRAP) staining, and quantitative real-time PCR (RT-qPCR).

Cytotoxic Indolyl Diketopiperazines from the sp. GZWMJZ-258, Endophytic with the Medicinal and Edible Plant .

Two new indolyl diketopiperazines, gartryprostatins A and B ( and ), with an unusual 2,3-furan-fused pyrano[2,3-]pyrrolo[1″,2″:4',5']pyrazino[1',2':1,5]pyrrolo[2,3-]indole nucleus, along with a new naturally occurring compound (gartryprostatin C, ) were isolated from the solid culture of sp. GZWMJZ-258, an endophyte from (Guttiferae). The structures of compounds - were determined by nuclear magnetic resonance, mass spectrometry, Marfey's analysis of amino acids, and chemical calculation.

Using α-Pinene-Modified Triethoxysilane as the New Cross-Linking Agent To Improve the Silicone Rubber Properties.

α-Pinene-modified triethoxysilane (α-PTES) was synthesized by hydrosilylation in the presence of Karstedt's catalyst. The structure of α-PTES was determined by Fourier transform infrared spectroscopy and nuclear magnetic resonance. Under the catalysis of an organotin catalyst, α-PTES, which was the cross-linking agent, and the hydroxy-terminated poly(dimethylsiloxane) matrix were utilized to prepare the room-temperature vulcanized silicone rubber.

A Single Enhanced Dual-Energy CT Scan May Distinguish Lung Squamous Cell Carcinoma From Adenocarcinoma During the Venous phase.

Rationale And Objectives: To investigate whether iodine quantification extracted from enhanced dual energy-computed tomography (DE-CT) is useful for distinguishing lung squamous cell carcinoma from adenocarcinoma and to evaluate whether a single scan evaluated during the venous phase (VP) can be substituted for scans evaluated during other phases.

Materials And Methods: Sixty-two patients with lung cancer (32 squamous cell carcinomas; 30 adenocarcinomas) underwent enhanced dual-phase DE-CT scans, including an arterial phase and VP. The iodine concentration (IC), normalized iodine concentration (NIC), and slope of the curve (K) in lesions were measured during two scanning phases in two different pathological types of lung cancers.

Understanding the factors influencing health professionals' online voluntary behaviors: Evidence from YiXinLi, a Chinese online health community for mental health.

Background: Normal users' voluntary behaviors (e.g., knowledge sharing) in virtual communities (VCs) has been well investigated; however, research on health professionals' voluntary behaviors in online health communities (OHCs) is limited.

An Uncommon Case of Double-Hit Mantle Cell Lymphoma That Demonstrates a Transformation Process.

Objectives: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by CCND1/IGH rearrangement. We reported a case of MCL harboring both CCND1/IGH and MYC/IGH rearrangements that also presented with an aggressive clinical course.

Methods: Biopsy specimens were evaluated by morphological staining, immunohistochemistry, flow cytometry, conventional cytogenetics, fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS).

Role of the Btk-PLC2 Signaling Pathway in the Bone Destruction of Apical Periodontitis.

Chronic apical periodontitis is characterized by alveolar bone absorption in the apical region and is the result of the participation of various inflammatory mediators. Studies have shown that the Bruton tyrosine kinase- (Btk-) phospholipase C2 (PLC2) signaling pathway plays an important role in bone absorption, but it is unknown whether it plays a role in apical periodontitis bone destruction. Therefore, this study verified the role of Btk and PLC2 in bone resorption of apical periodontitis by and experiments.

Semisynthetic Derivatives of Fradcarbazole A and Their Cytotoxicity against Acute Myeloid Leukemia Cell Lines.

Fourteen derivatives of the marine-derived fradcarbazole A were synthesized from staurosporine. Their structures were identified by NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS). The derivatives were screened in vitro for antiproliferative activity against three human leukemic cell lines (MV4-11, HL-60, K562).

Microstructure Control and Performance Evolution of Aluminum Alloy 7075 by Nano-Treating.

Nano-treating is a novel concept wherein a low percentage of nanoparticles is used for microstructural control and property tuning in metals and alloys. The nano-treating of AA7075 was investigated to control its microstructure and improve its structural stability for high performance. After treatment with TiC nanoparticles, the grains were significantly refined from coarse dendrites of hundreds of micrometers to fine equiaxial ones smaller than 20 μm.

The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium.

Background: Gelsemium is a toxic flowering plant of the Gelsemiaceae family. It is used to treat skin diseases in China, and it is an important medicinal and homeopathic plant in North America. Up to now, more than 200 compounds have been isolated and reported from Gelsemium.

Crevice corrosion - A newly observed mechanism of degradation in biomedical magnesium.

Crevice-induced corrosion is not desirable to occur in metallic magnesium (Mg) during many industrial applications. However, orthopedic implants made of Mg alloys have been demonstrated to degrade faster between the joining surface of bone plates and screws after implantation, suggesting the crevice corrosion may occur in the physiological environment. In this paper, a resin device is designed to parallel high purity magnesium (HP-Mg) plates with closely spaced slits.

Simultaneous arsenic and fluoride removal using {201}TiO-ZrO: Fabrication, characterization, and mechanism.

The coexistence of arsenic (As) and fluoride (F) in drinking water is an urgent environmental issue that causes increasing public concerns. The need for effective simultaneous removal of As and F has motived great research efforts. Herein, a novel {201}TiO-ZrO composite was synthesized and its application mechanism was explored.

ACCUGRAM: A novel approach based on classification to frequency band selection for rotating machinery fault diagnosis.

Frequency band selection (FBS) in rotating machinery fault diagnosis aims to recognize frequency band location including a fault transient out of a full band spectrum, and thus fault diagnosis can suppress noise influence from other frequency components. Impulsiveness and cyclostationarity have been recently recognized as two distinctive signatures of a transient. Thus, many studies have focused on developing quantification metrics of the two signatures and using them as indicators to guide FBS.

Reconfigurable Microcube Assemblies at the Liquid/Air Interface: The Impact of Surface Tension on Orientation and Capillary-Force-Interaction-Driven Assembly.

The systematic investigation of the dependence of the orientation and capillary interaction of hydrophobized polystyrene microcubes at the liquid/air interface on the surface tension of the aqueous subphase is reported. By decreasing the subphase surface tension, the preferential orientation of the cubes was observed to change independent of the surfactant type from the vertex up to the edge up and finally to the face up. Concomitantly, the structure of the aggregates obtained by cube assembly was observed to change from a close-packed hexagonal to tilted linear and finally to flat plate.

Oxymatrine ameliorates insulin resistance in rats with type 2 diabetes by regulating the expression of KSRP, PETN, and AKT in the liver.

Insulin resistance plays a key role in the development and progression of type 2 diabetes mellitus (T2DM). Recent studies found that insulin resistance was associated with the dysfunction of KH-type splicing regulatory protein (KSRP) expression and AKT pathway, and that oxymatrine possesses an antidiabetic effect. The aim of the present study was to investigate whether the protection of oxymatrine against T2DM was associated with the modulation of the KSRP expression and AKT pathway.

Cytotoxic phenolic constituents from Hypericum japonicum.

Nine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racemates. The structures and absolute configurations of the undescribed compounds were determined by comprehensive MS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations.