[The effectiveness of the application of medicinal mineral water from the 'Omonkhona' source in the patients presenting with the diseases of the hepatobiliary system].

Background: Investigations into the medicinal properties of 'Omonkhona' mineral water used for the treatment of hepatobiliary pathology make up the entirely new field of balneological research in Uzbekistan.

Aim: The objective of the present study was to identify the hepatoprotective and choleretic components of the 'Omonkhona' mineral water and elucidate their action in the patients presenting with the diseases of the hepatobiliary system.

Material And Methods: A total of 77 patients suffering from the diseases of the hepatobiliary system were available for the examination including 38 patients with chronic hepatitis (CH), 17 with chronic cholecystitis (CC), and 22 patients with liver cirrhosis (Cr).

[Influence of meteopathogenic factors on population visits for emergency medical care].

Aim: To study the features of the impact of the extreme climate and weather factors of an arid area, which cause exacerbations of circulatory system diseases (CSD).

Materials And Methods: The authors have studied 32,339 visits for emergency medical care (EMC) because of exacerbations of CSD (coronary heart disease, angina pectoris (n = 29,932), myocardial infarction (n = 306), hypertensive crises (n = 2,101) and their events) when the Afghan wind forms in winter and spring and on heat discomfort days in summer. Meteological parameters, synoptic patterns, partial oxygen density (AOD) in the atmosphere, atmospheric electric potential gradient, and human heat sensation (equivalent and effective air temperatures (EEAT)) were estimated using the generally accepted three-hour gradations.

[The clinical efficiency and safety of iodide-bromine balneotherapy in patients with coronary heart disease concurrent with chronic obstructive pulmonary disease].

Aim: to evaluate the efficiency of iodide-bromine balneotherapy (IBB) in patients with coronary heart disease (CHD) concurrent with chronic obstructive pulmonary disease (COPD).

Subjects And Methods: Sixty-six patients with CHD, Functional Class HII stable angina on exertion concurrent with mild and moderate COPD were examined. Group 1 included 36 patients with CHD concurrent with mild and moderate COPD (a study group); Group 2 consisted of 30 patients (a control group).

[Potentiation of anti-ischemic and anti-anginal action of nitrates by hydrogen sulfide balneotherapy in patients with angina of effort].

The objective of this comparative study was to evaluate effects of nitrosorbid (NS) and hydrogen sulfide-based balneotherapy (HSB) applied alone or in combination for the treatment of patients presenting with angina of effort. It was shown that long-term HSB therapy enhances the anti-anginal and anti-ischemic action of NS in such patients. The authors argue that prolonged HSB-based maintenance therapy in combination with nitrates prevents habituation to these preparations and potentiates their beneficial therapeutic effect.

[Application of ammotherapy for the remedial treatment of patients with chronic obstructive pulmonary disease in the rehabilitative phase].

The objective of this study was to evaluate clinical and physiological efficiency of ammotherapy (PT) applied to the treatment of 112 patients in the phase of partial remission. It was shown that combination of standard baseline therapy and ammotherapy ensured positive dynamics of clinical symptoms and substantially improved parameters of external respiration and hemodynamics. It is concluded that ammotherapy can be recommended for a more extensive application to the management of chronic obstructive pulmonary disease.

[Efficacy and safety of hydrogen sulfide balneotherapy in ischemic heart disease the arid zone].

Aim: To evaluate efficacy of hydrogen sulfide (HS) balneotherapy in patients with coronary heart disease (CHD) in conditions of heat discomfort.

Material And Methods: The study included 72 CHD patients aged 35 to 60 years with stable angina pectoris of the second functional class taking balneotherapy in summer under arid climatic conditions. Before and after balneotherapy the patients were examined with estimation of clinical symptoms, stress bicycle exercise (SBE) parameters, number of nitroglycerine tablets.

[Clinical efficiency and tolerance of hydrogen sulfide balneotherapy in hypertensive patients living in arid zone].

Aim: To examine clinical efficiency and safety of moderate hydrogen sulfide (HS) baths in the treatment of hypertensive patients living in arid zones.

Material And Methods: Sixty patients with stable essential hypertension (EH) of stage I-II according to WHO classification living in arid climate took sparing HS baths. Efficiency of the baths was assessed by changes in blood pressure (BP), 24-h monitoring of BP.

[Basic etiological factors, pathogenetic mechanisms, and clinical forms of meteopathic reactions].

The paper reviews basic etiological factors of meteopathic reactions, presents a scheme of pathogenetic mechanisms of the development and clinical classification. Meteopathic reactions are attributed to the following causing factors: atmospheric electromagnetic impacts ("storms"), change of thermobaric situation ("hypoxic weather for "spastic"), weather situation of the intermediate type. Pathogenetic mechanisms of meteopathic reactions provoke the following developments: electromagnetic impacts irritate the cells of afferent nervous ends, weather hypoxic conditions aggravate lack of oxygen of affected organs and tissues, spasm of vascular smooth muscles worsens transport of oxygen to organs and tissues causing capillary-trophic insufficiency.

[Meteopathogenic mechanisms of exacerbating ischemic heart disease in an arid zone].

In arid zone of Uzbekistan summer heat discomfort aggravates the course of ischemic heart disease, provokes meteopathic reactions which we call "meteorological strain syndrome". In this season anginal attacks, episodes of arrhythmia and coronary failure become more frequent especially in patients over 70 years of age and migrants.

[Microcirculatory changes in patients with the initial manifestations of cerebral circulatory failure under the conditions of an arid zone].

Microcirculation was studied in 53 ICCD patients: 28 lived in comfortable weather conditions while 25 patients lived in heat discomfort in arid climatic zone. It is shown that heat discomfort led to compensatory microvascular reactions providing proper supply of oxygen to organs and tissues: tortuosity and dilation of the microvessels, opening of the capillaries, shunting in relative hypoxia and hyperthermia.

[The reserve potentials of patients with ischemic heart disease who live under the conditions of an arid zone].

Aim: The study of physical performance of ischemic heart disease (IHD) patients in comfortable and uncomfortable (summer) weather conditions.

Materials And Methods: Systemic reserves were assessed by physical performance tests in comfortable weather (equivalent-effective temperature--EET 18-24 degrees C) and in heat discomfort (EET 25-30 degrees C), i.e.

[Effect of climate of arid zone on adaptive and non-adaptive changes in microcirculation].

State of microcirculatory bed of the bulbar conjunctiva and nail wall skin has been studied in 134 men (18-28 years old) of native (62 men) and non-native (72 men) population. It was found out that under heat discomfort the compensation is observed in native population due to the induration of the capillary network, opening of plasmatic capillaries which did not function before, tonus of venules and arterioles being preserved while the amount of "gigantic" capillaries increased. In this case the blood flow was entire, uniform and moderately accelerated.

[Adaptive and non-adaptive reactions of central hemodynamics to conditions of heat discomfort].

Chest rheography was used to study central hemodynamics in 134 healthy males aged 18-28 in comfortable weather conditions and discomfortable ones, that is at equivalent-effective temperature 17-24 degrees C and above 27-30 degrees C, respectively. In trained subjects from native and non-native population under comfortable weather conditions heart rate (HR) proved to be significantly reduced as compared to untrained subjects (57.6 +/- 1.

[Physical work capacity as a criterion of human resistance under the hot climatic conditions of an arid zone].

In heat discomfort, physically trained subjects had a high and stable physical working ability (PWA) whereas untrained subjects revealed a considerable decline of the parameter. A lesser work was performed with a greater tension of the cardiorespiratory system. The data obtained suggest a high and stable PWA is one of the main criteria of the organism's adaptation to hot climate conditions of the arid zone.

[Adaptive and maladaptive reactions of the external respiration in the climatic conditions of an arid zone].

Physical performance was assessed in 134 healthy males aged 18-28, residents of the southern Uzbekistan. They were divided into two groups according to the results of bicycle exercise. Group I subjects (32 natives and 38 non-natives) exhibited high physical efficacy, group II subjects--low efficacy (30 and 34 natives and non-natives, respectively).

[The central hemodynamic reaction of patients with ischemic heart disease to the climatic and weather conditions of an arid zone].

Central hemodynamics of coronary patients living in the arid zone (215 males aged 40-72 and 150 females aged 40-75) was assessed in comfortable weather conditions, 1-2 days before the invasion of the dust storm, upon its invasion and in hot weather season (+26-30 degrees C). Angina of effort functional class I, II and III was in 102, 198 and 65 patients, respectively. Atmospheric conditions before the invasion of the dust storm form a hypoxic type of weather while on the day of the storm the weather appears spastic resulting in arterial hypertension, elevated total peripheral resistance and heart beat in diminution of cardiac output and stroke volume.