Simalikalactone D, a Potential Anticancer Compound from , an Endemic Plant of Puerto Rico.

Species of the genus have been studied because of their antimalarial and antileukemic activities. A group of oxygenated terpenes called quassinoids have been isolated from species of the genus, and are responsible for its therapeutic properties. We hypothesized that , an endemic plant from Puerto Rico, is a natural source rich in quassinoid compounds with anticancer activity.

Synthesis, Anti-Cancer and Anti-Migratory Evaluation of 3,6-Dibromocarbazole and 5-Bromoindole Derivatives.

In this study, a new series of -alkyl-3,6-dibromocarbazole and -alkyl-5-bromoindole derivatives have been synthesized and evaluated in vitro as anti-cancer and anti-migration agents. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines and an insight on the structure-activity relationship was developed. Preliminary investigations of their anti-cancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI values in the range of 4.

Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents.

Based on the efficacy of EHop-016 as an inhibitor of migration and Rac1 activation, a new series of carbazole derivatives has been synthesized. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. Preliminary investigations of their anticancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI values in the range of 13-50 µM.