Publications by authors named "Zulkifli A"

Article Synopsis
  • Parental smoking is the main source of secondhand smoke exposure in children, leading to respiratory issues, and promoting smoke-free homes is crucial, particularly in rural areas like Kuala Kubu Bharu, Malaysia.
  • The study used surveys and interviews in 2022 to assess knowledge and beliefs about secondhand smoke, with 60 participants showing moderate understanding but revealing barriers like personal convenience and social influence to adopting smoke-free practices.
  • Findings indicate a need for tailored health promotion efforts in these communities, as men's beliefs about smoking cessation may hinder smoke-free home adoption, highlighting the importance of culturally sensitive interventions.
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Diseases of Theobroma cacao L. (Malvaceae) disrupt cocoa bean supply and economically impact growers. Vascular streak dieback (VSD), caused by Ceratobasidium theobromae, is a new encounter disease of cacao currently contained to southeast Asia and Melanesia.

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Background: Hospital resilience has been well recognized among healthcare managers and providers as disruption of hospital services that threatens their business environment. However, the shocks identified in the recent hospital resilience concept are mainly related to disaster situations. This study aims to identify potential shocks that hospitals face during disruptions in Indonesia.

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  • Proper disposal of pharmaceuticals is crucial due to public health and environmental concerns, with a focus on understanding medication disposal habits among Malaysians.
  • A study surveyed 389 participants, revealing that most dispose of unused medicines in the trash, while only 26.2% engaged in the Medicine Return Program (MRP).
  • Important factors influencing MRP participation include receiving advice from healthcare providers and awareness of environmental contamination, which can guide public health strategies for better disposal practices.
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) caused imminent acute infection of respiratory tract known as Coronavirus disease 2019 (COVID-19). Complications of hepatobiliary system especially liver often found in post-acute COVID-19 patients. However, there are only few studies specifically discussing about liver abscess in patients who had history of contracted COVID-19.

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Malaysia is the second largest producer and exporter of palm oil. Though several works have explored achieving emissions reduction in the palm oil sector, there existing gaps in analysing pathways for achieving net-zero emissions. Moreover, there are limited studies that evaluate the potential of palm oil biomass utilisation pathways based on emissions reduction capabilities, the cost of emissions reduction, and the technology readiness for implementation.

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Hypertension (HPT) is the leading modifiable risk factor for cardiovascular diseases and premature death worldwide. Currently, attention is given to various dietary approaches with a special focus on the role of micronutrient intake in the regulation of blood pressure. This study aims to measure the dietary intake of selected minerals among Malaysian adults and its association with HPT.

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Introduction: Since the COVID-19 pandemic began, it has spread rapidly across the world and has resulted in recurrent outbreaks. This study aims to describe the COVID-19 epidemiology in terms of COVID-19 cases, deaths, ICU admissions, ventilator requirements, testing, incidence rate, death rate, case fatality rate (CFR) and test positivity rate for each outbreak from the beginning of the pandemic in 2020 till endemicity of COVID-19 in 2022 in Malaysia.

Methods: Data was sourced from the GitHub repository and the Ministry of Health's official COVID-19 website.

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Background: The studies of hospital resilience have been of increasing importance during the last decade due to disasters and pandemics. However, studies in developing the domain and indicators of hospital resilience were limited mainly on disaster response. A few studies of hospital resilience focused on how to deal with disruptions such as environmental turbulence, rapid technological changes, and changes in patient preferences.

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Objectives: This study aimed to develop susceptible-exposed-infectious-recovered-vaccinated (SEIRV) models to examine the effects of vaccination on coronavirus disease 2019 (COVID-19) case trends in Malaysia during Phase 3 of the National COVID-19 Immunization Program amidst the Delta outbreak.

Methods: SEIRV models were developed and validated using COVID-19 case and vaccination data from the Ministry of Health, Malaysia, from June 21, 2021 to July 21, 2021 to generate forecasts of COVID-19 cases from July 22, 2021 to December 31, 2021. Three scenarios were examined to measure the effects of vaccination on COVID-19 case trends.

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Article Synopsis
  • - Osteoarthritis (OA) is the most common chronic joint disease and leads to significant societal costs, but current treatments don't effectively stop or reverse the damage to cartilage, which is crucial in OA progression.
  • - The loss or malfunction of chondrocytes, which are the cells responsible for maintaining cartilage, is a key factor in cartilage breakdown, and their death through a process called apoptosis contributes to this deterioration.
  • - Autophagy, a cell survival mechanism that helps get rid of damaged components, could be a promising treatment target to prevent chondrocyte apoptosis and slow down OA; however, more research is needed to understand how autophagy and apoptosis are connected in these cells.
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Background: Globally, the COVID-19 pandemic has affected the transmission dynamics and distribution of dengue. Therefore, this study aims to describe the impact of the COVID-19 pandemic on the geographic and demographic distribution of dengue incidence in Malaysia.

Methods: This study analyzed dengue cases from January 2014 to December 2021 and COVID-19 confirmed cases from January 2020 to December 2021 which was divided into the pre (2014 to 2019) and during COVID-19 pandemic (2020 to 2021) phases.

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Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies. Accumulated evidence implied that prenatal exposure to VPA is highly associated with autism spectrum disorder (ASD). In this study, the zebrafish were exposed to a set of VPA concentrations (0, 5, 10, 20, 40, 80, 160, 320, 640, 1280, and 2560 μM) at 5 h post fertilization (hpf) to 120 hpf.

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Article Synopsis
  • - Tendon injuries are common and difficult to treat due to slow healing and poor tissue repair, often resulting in weakened, disorganized tissue.
  • - Mesenchymal stem cell (MSC) therapy shows promise for improving tendon repair, especially when MSCs are exposed to low oxygen (hypoxic) conditions, which boosts their ability to differentiate into tendon cells.
  • - The review explores how hypoxia-inducible factor-1-alpha (HIF-1α) is crucial in this process, particularly its interactions with growth factors like FGF-2 and TGF-β1, and highlights strategies to enhance HIF-1α to improve MSC therapy effectiveness.
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Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued progression in low-glucose concentrations. However, the regulatory cytokine networks that govern the ability to survive in glucose-starved conditions are not fully defined. In the present study, we define a critical role for the IL-11/IL-11Rα signalling axis in glioblastoma survival, proliferation and invasion when cells are starved of glucose.

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Depression is the most common mental health problem affecting adolescents globally, wherein its increasing prevalence together with the negative health impacts escalates the need for further research in this area. This work determined the prevalence and factors associated with depressive symptoms among young adolescents in Malaysia. A total of 1350 adolescent aged 13 to 14 years in school across nine secondary schools in Selangor state, Malaysia participated in a cross-sectional study.

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Article Synopsis
  • The ChoCO-W study aimed to examine the effects of COVID-19 on the clinical presentation and outcomes of acute cholecystitis, particularly focusing on the rise of gangrenous cases during the pandemic.
  • Over 2,800 patients from 42 countries were enrolled, with a notable 6.9% testing positive for COVID-19, revealing a significantly higher prevalence of preexisting conditions and more severe outcomes in this group compared to those without the virus.
  • Patients with COVID-19 experienced higher postoperative complications (32.2% vs. 11.7%), longer hospital stays (13.21 days vs. 6.51 days), increased mortality rates (13.4% vs. 1.7
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Introduction: Despite the health risks associated with secondhand smoke (SHS) exposure, smoking in the home is common in Malaysia, and almost exclusively a male behavior.

Aims And Methods: This study explored male smokers' knowledge, beliefs, and behaviors related to SHS exposure and smoking in the home, to guide future intervention development. Twenty-four men who smoked and lived in Klang Valley, Kuantan, or Kuala Terengganu took part in semi-structured interviews which explored knowledge and beliefs regarding SHS in the home, and associated home-smoking behaviors.

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Introduction: Extensive regulations have been introduced to reduce secondhand smoke (SHS) exposure among non-smokers in Malaysia. However, there is still a need to encourage behavior change of smokers in relation to making homes smoke-free. This feasibility study aimed to use low-cost air pollution monitors to quantify SHS concentrations in Malaysian households and to explore the practicality of using personalized feedback in educating families to make their homes smoke-free.

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Urban agriculture plays a vital role in ensuring the self-sufficiency of a great variety of fresh vegetables and nutrients. It promotes a sustainable food system as well as reducing the dependency on imports for the growing population. Urban farming has made it possible for agriculture practices to be implemented anywhere at any time in a sophisticated way.

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This study aimed to describe the characteristics of COVID-19 cases and close contacts during the first wave of COVID-19 in Malaysia (23 January 2020 to 26 February 2020), and to analyse the reasons why the outbreak did not continue to spread and lessons that can be learnt from this experience. Characteristics of the cases and close contacts, spatial spread, epidemiological link, and timeline of the cases were examined. An extended SEIR model was developed using several parameters such as the average number of contacts per day per case, the proportion of close contact traced per day and the mean daily rate at which infectious cases are isolated to determine the basic reproduction number (R) and trajectory of cases.

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Objective: The most influence of occurrence children stunted are those related to food, both in terms of quantity and quality. The aim of this study is seeing of the relationship between dietary diversity, dietary pattern and dietary intake for children stunted.

Methods: This study is a follow up of the previous study of nutrition interventions in children, where the total sample size children was 340 measured the dietary intake with 24-hour recall.

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Cellulose is one of the most abundant natural polymers with excellent biocompatibility, non-toxicity, flexibility, and renewable source. Regenerated cellulose (RC) products result from the dissolution-regeneration process risen from solvent and anti-solvent reagents, respectively. The regeneration process changes the cellulose chain conformation from cellulose I to cellulose II, leads the structure to have more amorphous regions with improved crystallinity, and inclines towards extensive modification on the RC products such as hydrogel, aerogel, cryogel, xerogel, fibers, membrane, and thin film.

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Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing.

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