Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan.

Ethnopharmacologic Relevance: Artemisia judaica L. (Arabic name: Beithran), is a medicinal and aromatic plant growing in the valley bottoms of desert areas, particularly in the southern desert of Jordan nearest to the Jordan-Saudi Arabia borders and in Wadi Araba in the Southern Badia. In Jordan, A.

An Investigation of Multidimensional Voice Program Parameters in Three Different Databases for Voice Pathology Detection and Classification.

Background And Objective: Automatic voice-pathology detection and classification systems may help clinicians to detect the existence of any voice pathologies and the type of pathology from which patients suffer in the early stages. The main aim of this paper is to investigate Multidimensional Voice Program (MDVP) parameters to automatically detect and classify the voice pathologies in multiple databases, and then to find out which parameters performed well in these two processes.

Materials And Methods: Samples of the sustained vowel /a/ of normal and pathological voices were extracted from three different databases, which have three voice pathologies in common.

Tandem Mass Spectrometry for Structural Identification of Sesquiterpene Alkaloids from the Stems of Dendrobium nobile Using LC-QToF.

Dendrobium nobile is one of the fundamental herbs in traditional Chinese medicine. Sesquiterpene alkaloids are the main active components in this plant. Due to weak ultraviolet absorption and low content in D.

EFFECTIVENESS OF COMMUNITY SERVICE MODEL FOR INCREASING ROUTINE IMMUNIZATION COVERAGE AT PRIMARY HEALTHCARE FACILITIES IN A RURAL DISTRICT OF PAKISTAN: A QUASI-EXPERIMENTAL STUDY.

Background: In Pakistan Routine Immunization coverage has been reported to be significantly low due to multiple factors that results in high number of deaths in children under 5. This study was conducted to assess the effectiveness of integrating Community Services to improve Routine immunization coverage in rural district of Pakistan.

Methods: A quasi-experimental study with control and intervention arms was conducted in government Basic Health unit's catchment population of Panjgur by interviewing household head/Fathers.

Investigation of Voice Pathology Detection and Classification on Different Frequency Regions Using Correlation Functions.

Objectives And Background: Automatic voice pathology detection and classification systems effectively contribute to the assessment of voice disorders, which helps clinicians to detect the existence of any voice pathologies and the type of pathology from which patients suffer in the early stages. This work concentrates on developing an accurate and robust feature extraction for detecting and classifying voice pathologies by investigating different frequency bands using correlation functions. In this paper, we extracted maximum peak values and their corresponding lag values from each frame of a voiced signal by using correlation functions as features to detect and classify pathological samples.

Cytotoxic monacolins from red yeast rice, a Chinese medicine and food.

Seven new monacolins, monacolins Q-S (1-3), α,β-dehydromonacolin S (4), 3α-hydroxy-3,5-dihydromonacolin L (5), 3β-hydroxy-3,5-dihydromonacolin L (6), and α,β-hydromonacolin Q (7) were isolated and characterized from the methanol extract of red yeast rice. In addition, six known monacolins, α,β-dehydrodihydromonacolin K (8), dehydromonacolin K (9), dehydromonacolin L (10), monacolin K (11), dihydromonacolin K (12), dihydromonacolin L (13) and two compounds other than monacolins (14, 15) were also isolated. Structure elucidation of the isolates was achieved by means of NMR and mass spectroscopic data analyses.

Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults.

Background: Rocuronium bromide is a routinely used muscle relaxant in anaesthetic practice. Its use, however, is associated with intense pain on injection. While it is well established that rocuronium bromide injection causes pain in awake patients, anaesthetized patients also tend to show withdrawal movements of the limbs when this muscle relaxant is administered.

The nuclear protein GmbZIP110 has transcription activation activity and plays important roles in the response to salinity stress in soybean.

Plant basic-leucine zipper (bZIP) transcription factors play important roles in many biological processes and are involved in the regulation of salt stress tolerance. Previously, our lab generated digital gene expression profiling (DGEP) data to identify differentially expressed genes in a salt-tolerant genotype of Glycine soja (STGoGS) and a salt-sensitive genotype of Glycine max (SSGoGM). This DGEP data revealed that the expression (log2 ratio) of GmbZIP110 was up-regulated 2.

EFFECT OF INTRAOPERATIVE MITOMYCIN-C APPLICATION IN OUTCOME OF EXTERNAL DACRYOCYSTORHINOSTOMY.

Background: Patients develop postoperative fibrosis at the site of operation after dacryocystorhinostomy (DCR) which results in impairment of the osteum patency. This quasi-experimental study was undertaken to determine the role of intraoperative Mitomycin C (MMC) application in maintaining postoperative patency of the osteum.

Methodology: The present study was conducted at the Eye department of Ayub Medical College, Abbottabad on patients in whom routine DCR was indicated.

Comparative effects of Mitragyna speciosa extract, mitragynine, and opioid agonists on thermal nociception in rats.

This study sought to compare the effects of Mitragyna speciosa (Korth.) Havil. extract, alkaloids fraction, and mitragynine, a μ-opioid receptor agonist, to that of morphine and oxycodone in a test of thermal nociception.

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.

Previously, we observed that wild yam (Dioscorea villosa) root extract (WYRE) was able to activate GATA3 in human breast cancer cells targeting epigenome. This study aimed to find out if dioscin (DS), a bioactive compound of WYRE, can modulate GATA3 functions and cellular invasion in human breast cancer cells. MCF-7 and MDA-MB-231 cells were treated in the absence/presence of various concentrations of DS and subjected to gene analysis by RT-qPCR, immunoblotting, and immunocytochemistry.

HPLC Method for Chemical Fingerprinting of Guggul (Commiphora wightii)--Quantification of E- and Z-Guggulsterones and Detection of Possible Adulterants.

A reversed-phase high-performance liquid chromatography method was developed for the chemical fingerprinting of Commiphora wightii gum resin (guggul). This method was also used for the quantification of E- and Z-guggulsterones in different C. wightii gum resin samples.

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.

Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extracts also contain a number of other flavonoids, isoflavonoids, and chalcones. We have investigated the estrogenic activity of 7 of these components, obtained from an extract of Glycyrrhiza glabra powder, namely Glabridin (L1), Calycosin (L2), Methoxychalcone (L3), Vestitol (L4), Glyasperin C (L5), Glycycoumarin (L6), and Glicoricone (L7), and compared them with Liq, Iso-Liq, and estradiol (E2).

Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS.

The aim of this study was to examine hepatoprotective effect of ethanolic extract of propolis (KPEt) from Kashmir Himalaya against isoniazid and rifampicin (INH-RIF) induced liver damage in rats. Hepatic cellular injury was initiated by administration of INH-RIF combination (100 mg/kg) intraperitoneal (i.p.

Detection of Voice Pathology using Fractal Dimension in a Multiresolution Analysis of Normal and Disordered Speech Signals.

Voice disorders are associated with irregular vibrations of vocal folds. Based on the source filter theory of speech production, these irregular vibrations can be detected in a non-invasive way by analyzing the speech signal. In this paper we present a multiband approach for the detection of voice disorders given that the voice source generally interacts with the vocal tract in a non-linear way.

Automatic Voice Pathology Detection With Running Speech by Using Estimation of Auditory Spectrum and Cepstral Coefficients Based on the All-Pole Model.

Background And Objective: Automatic voice pathology detection using sustained vowels has been widely explored. Because of the stationary nature of the speech waveform, pathology detection with a sustained vowel is a comparatively easier task than that using a running speech. Some disorder detection systems with running speech have also been developed, although most of them are based on a voice activity detection (VAD), that is, itself a challenging task.

Hydropiperside, a new sphingoglycolipid from Polygonum hydropiper.

One new sphingoglycolipid, hydropiperside, along with two known compounds, flaccidine and quercetin were isolated from the methanolic extract of Polygonum hydropiper. Elucidation of structures was achieved by NMR (1D and 2D) data, mass (EI and FAB) spectroscopy and chemical means.

In situ formed Bi/BiOBrxI1-x heterojunction of hierarchical microspheres for efficient visible-light photocatalytic activity.

Bi nanoparticles deposited in situ in BiOBrxI1-x hierarchical microspheres (Bi/BiOBrxI1-x heterojunction) were synthesized by a facile one-step solvothermal method. The as-prepared samples were characterized via XRD, SEM, TEM, XPS, UV-vis absorption spectroscopy and N2 adsorption-desorption. The hierarchical microspheres were composed of numerous nanosheets aggregated together compactly to form a spherical geometry.

Identification and Characterization of Indole and Oxindole Alkaloids from Leaves of Mitragyna speciosa Korth Using Liquid Chromatography-Accurate QToF Mass Spectrometry.

Alkaloids have been reported to be the major physiologically active constituents in Mitragyna. An analytical method was developed to provide an alternative, fast method for characterization of alkaloids from various M. speciosa samples.

Blood transfusion practices in neuroanaesthesia.

Neuroanaesthesia practice is associated with risk of significant blood loss resulting in anaemia in the intraoperative and postoperative period. The transfusion triggers in a neurologically injured brain are not clearly defined. Both a low haematocrit and a high haematocrit have not shown any improvement in the outcome.

Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes.

The chemical compositions of essential oils obtained from four species of genus Salvia were analyzed by gas chromatography with a flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The main compounds identified from Salvia species essential oils were as follows: 1,8-cineole (71.7%), α-pinene (5.

Alkaline phosphatase activity-guided isolation of active compounds and new dammarane-type triterpenes from Cissus quadrangularis hexane extract.

Ethnopharmacological Relevance: The stem of Cissus quadrangularis L. (CQ) is used in traditional medicine to treat bone fractures and swelling. Anti-osteoporotic activity of CQ hexane extract has been reported, but the active compounds in this extract remain unknown.