Publications by authors named "Zulfiqar Ali Raza"

Synthetic plastics are in great demand in society due to their diversified properties, but they cause environmental pollution due to their non-biodegradable nature. Therefore, synthetic plastics are in need to be replaced with biodegradable plastics. Polyhydroxyalkanoates (PHAs), bacterial biopolymers are natural alternative to synthetic plastics.

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Biomaterial-based drug-carrying systems have scored enormous focus in the biomedical sector. Poly(lactic acid) (PLA) is a versatile material in this context. A porous and hydrophilic PLA surface can do this job better.

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In the present study, a range of sustainable, biocompatible and biodegradable polyurethanes (PU-1 to PU-4) were synthesized using different combinations of biobased polyol (obtained through the epoxidation of soybean oil, followed by ring opening with ethanol) and polyethylene glycol (PEG) and isophorone diisocyanate. The sustainable chain extender used in this study was synthesized by the esterification of lactic acid with ethylene glycol (EG). The synthesized PU samples were characterized through scanning electron microscopy (SEM), Fourier transformed infrared (FTIR) and nuclear magnetic resonance (H NMR and C NMR) spectroscopy.

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Article Synopsis
  • - Photocatalysis is an eco-friendly method using light and specific materials to break down pollutants, and this study focuses on using citrate-functionalized silver nanoparticles (SNPs) for this purpose on cellulosic fabric.
  • - The research examines the ability of these modified fabrics to serve as microfiltration membranes for removing organic dyes from water, showing successful degradation of the dye crystal violet into less harmful products.
  • - Findings indicate that the citrate-functionalized SNPs enhance both the antibacterial properties and photocatalytic efficiency of the cellulose membranes, making them effective for repeated cycles of water purification.
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Bio-based drug delivery devices have gained enormous interest in the biomedical field due to their biocompatible attributes. Extensive research is being conducted on chitosan-based devices for drug delivery applications. Chitosan being hydrophobic under neutral conditions makes it difficult to interact with a polar drug of curcumin.

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Hydrophobic textiles have been considered extensively for self-cleaning, phase-separating, and biomedical curing applications. We focused on preparing an eco-friendly lignin-based bio-finish to develop superhydrophobic cellulose fabric under mild conditions. The mass spectroscopic analysis expressed that the lignin comprised the major constituents of p-coumaryl alcohol, ferulic acid, coniferyl alcohol, and sinapyl alcohol.

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Membrane technology has extensively been used in diverse phenomena such as separation, purification and controlled transportation. Herein, gelatin-incorporated porous chitosan membranes have been prepared using the sol-gel approach for potential water desalination applications. The porogens of poly(ethylene glycol) and Triton X-100 were employed for the mentioned purpose.

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Article Synopsis
  • Polylactic acid (PLA) is a biodegradable plastic widely studied in biomedical applications due to its safety and compatibility, but it struggles with low functionalization and water resistance.
  • Cold plasma treatment (CPT) is used to enhance the hydrophilic properties of PLA films, making them more effective for controlled and rapid drug release, beneficial in wound healing scenarios.
  • The study investigates the effects of CPT on PLA and PLA@PEG films, revealing that CPT enhances surface properties and accelerates the release of the model drug streptomycin sulfate, indicating strong potential for drug delivery applications.
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The present study dealt with the fabrication of zinc sulfide (ZnS) nanoparticles (NPs), prepared using the chemical precipitation method, mediated poly(hydroxybutyrate) (PHB)/poly(lactic acid) (PLA) composite films employing the solution casting approach. The films were characterized based on structural, surface, chemo-physical, thermal, electrical, antibacterial, UV protection and degradation profiles. The results demonstrated the successful formation of nanobiocomposite films with good intercalation of the constituents.

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  • The COVID-19 pandemic has highlighted the critical importance of cleanliness, particularly through effective hand hygiene, to prevent the spread of infections, including SARS-CoV-2.
  • Experts often recommend using harsh chemicals for disinfection, but these can be unsafe and lead to negative health effects.
  • Biosurfactants have emerged as a safer, sustainable alternative for cleaning and disinfecting surfaces, demonstrating effectiveness against microbial pathogens due to their unique properties.
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Gelatin's versatile functionalization offers prospects of facile and effective crosslinking as well as combining with other materials (e.g., metal nanoparticles, carbonaceous, minerals, and polymeric materials exhibiting desired functional properties) to form hybrid materials of improved thermo-mechanical, physio-chemical and biological characteristics.

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This study presents the encapsulation of spearmint oil (SMO) in chitosan microstructures prepared through the emulsion formation method. The SMO although is medicinally significant yet finds limited applications in medical and functional textiles because of its less stability and high volatility under ambient conditions. Nevertheless, its encapsulation in chitosan may enhance its stability and applicability for the said purpose.

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We report the synthesis of a novel electrochemical biosensor comprising of cupric oxide (CuO) nanoparticles (NPs) mediated poly(hydroxybutyrate) (PHB) composite film with polyvinyl alcohol (PVA) as a binder/template support using the solution casting method for the detection of a biomolecule i.e., ascorbic acid (AA).

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Globally, millions of people have no access to clean drinking water and are either striving for that or oppressed to intake polluted water. Arsenic is considered one of the most hazardous contaminants in water bodies that reaches there due to various natural and anthropogenic activities. Modified chitosan has gained much attention from researchers due to its potential for arsenic removal.

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Electrospinning has become an inevitable approach to produce nanofibrous structures for diverse environmental applications. Polysaccharides, due to their variety of types, biobased origins, and eco-friendly, and renewable nature are wonderful materials for the said purpose. The present review discusses the electrospinning process, the parameters involved in the formation of electrospun nanofibers in general, and the polysaccharides in specific.

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Objective: Polysaccharide-based biomaterials are extensively used in wound care healing due to their unique liquid absorption, gelling properties and biocompatibility properties. They play an important role in controlling infections of highly exuding hard-to-heal wounds. The main objective of this study was to develop silver-containing polysaccharide-based tricomponent antibacterial fibres for use in these complex wounds.

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We report the preparation of both control chitosan and magnetic chitosan beads as biosorbents using chitosan as matrix and magnetite (FeO) nanoparticles as reinforcement followed by detailed advanced characterization. The batch trials were performed to study the adsorption kinetics of biosorbents by removing As and As species from water systems. The experimental data was inserted into Langmuir and Freundlich's isotherms to undertake the mechanism and adsorption capacity of the test biosorbents.

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Poly(hydroxybutyrate) (PHB) has been considered as a promising biopolymer produced in certain microbes under specific fermentative and physiological conditions. Being less functional, hydrophobic and brittle, the processability of PHB is difficult which limits its widespread applications. However, its blends with suitable biopolymers, for instance biopolyesters, may impart in them desirable structural functionalities and properties, such as surface reactivity, amphiphilicity, controlled degradation and mechanical strength; thus making them inevitable candidates for biomedical applications.

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Microencapsulation being an emerging technique has provided effective solution to the challenges faced by pharmaceutical, cosmetic, food agriculture and textile industries to deliver ingredients in their active forms to the target sites. Chitosan is a non-toxic, biodegradable and biocompatible amino polysaccharide which makes it useful for the encapsulation of various active ingredients with potential applications. Chitosan coating on food products, for example, gives them protection from possible antimicrobial attacks, antioxidants and extended shelf life.

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio-based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco-friendly nature, PHB can be used in line with bioactive species.

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Polyhydroxyalkanoates (PHAs) are biological plastics that are sustainable alternative to synthetic ones. Numerous microorganisms have been identified as PHAs producers. They store PHAs as cellular inclusions to use as an energy source backup.

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Cancer is one of the most dangerous diseases which had been encountering the human beings since last several decades. In 2018, according to national cancer institute, about 609,640 people are expected to die from cancer and about 1,735,350 new patients are expected to be diagnosed with this lethal disease. Nanotechnology has played a significant role in almost every field of life including medical sciences.

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Article Synopsis
  • Pseudomonas aeruginosa and Staphylococcus aureus are dangerous bacteria that create biofilms, posing a significant health risk due to their antibiotic resistance and prevalence in industrial and clinical settings.
  • Researchers have developed a simple method to create rhamnolipid-coated silver and iron oxide nanoparticles that can effectively combat these biofilms.
  • These nanoparticles work by generating reactive oxygen species and altering their surface properties to prevent bacterial adhesion, offering promising applications for reducing infections and improving medical treatments like wound dressings.
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  • Researchers created antibacterial fibres made from psyllium, sodium alginate, and hydrolysed chitosan to explore their potential healthcare applications.
  • The study examined how different amounts of hydrolysed chitosan affected the fibres' physical properties and their ability to combat bacteria like Staphylococcus aureus and Escherichia coli.
  • Results indicated that these new fibres were thicker and stronger than control fibres, with better antibacterial performance against Gram-positive bacteria, especially as the viscosity of the chitosan solution decreased.
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