Multicentre study of magnet ingestion in Spanish paediatric emergency departments.

Introduction: The ingestion of magnetic objects can cause complications in children, and there are no epidemiological or clinical data on the subject in Spain.

Objectives: To determine the incidence, epidemiological characteristics and management of magnet ingestion in paediatric emergency departments in Spain.

Material And Methods: Prospective observational multicentre study conducted over a 3-year period.

Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.

Pathogenic RIPK1 variants have been described as the cause of two different inborn errors of immunity. Biallelic loss-of-function variants cause the recessively inherited RIPK1 deficiency, while monoallelic variants impairing the caspase-8-mediated RIPK1 cleavage provoke a novel autoinflammatory disease (AID) called cleavage-resistant RIPK1-induced autoinflammatory (CRIA) syndrome. The aim of this study was to characterize the pathogenicity of two novel RIPK1 variants located at the cleavage site of caspase-8 detected in patients with dominantly-inherited, early-onset undefined AID.

Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain.

Background: Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics.

Objectives: To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA.

Methods: Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments.