Nitric oxide is involved in the memory facilitation induced by spermidine in rats.

Rationale: Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation.

Objectives: In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.

Results: The coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.