Evaluation of isotretinoin effects on depression, sleep apnea and sleep quality.

Background: Isotretinoin is used to treat severe acne, treatment-resistant moderate acne, and acne that leads to scarring or psychological distress. It has many side effects and is also associated with depression, sleep apnea, and sleep disturbances.

Objectives: In this study, we aimed to evaluate the effects of isotretinoin on depression, sleep apnea, and sleep quality.

Cutaneous metastases different clinical presentations: case series and review of the literature.

Cutaneous metastasis (CM) is a rare clinical entity with an incidence of less than 10% among oncology patients. Dissemination to the skin can be via bloodstream, lymphatics, direct expansion or by seeding after surgical procedures. Skin metastases usually develop months to years after the diagnosis of the primary tumor, while it may be the opposite in some rare cases.