Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy.

Background: Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may influence this disease. The aim of the present study was to test the relationship between IC development and the impact of single nucleotide polymorphisms (SNPs) in mitochondrial DNA (mtDNA) defining the mitochondrial haplogroups in a population study.

[Chronic anemia in heart transplant patients: prevalence, predisposing factors and prognostic significance].

Introduction And Objectives: Data on chronic anemia following heart transplantation (HT) are scarce and contradictory. Our aims were to determine the prevalence of chronic anemia after HT, to identify predisposing factors for the condition at 12 months, and to evaluate its influence on medium-term and long-term survival.

Methods: Retrospective analysis of patients who underwent HT between 1991 and 2005 (n=457).