Immunogenicity and Protective Capacity of Sugar ABC Transporter Substrate-Binding Protein against Serotype 2, 7 and 9 Infection in Mice.

() is a Gram-positive bacterium that causes substantial disease in pigs. is also an emerging zoonoses in humans, primarily in Asia, through the consumption of undercooked pork and the handling of infected pig meat as well as carcasses. The complexity of epidemiology, characterized by the presence of multiple bacterial serotypes and strains with diverse sequence types, identifies a critical need for a universal vaccine with the ability to confer cross-protective immunity.

Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice.

is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of broadly cross-reactive universal vaccine antigen targets, capable of providing cross-protection against infection. Subunit vaccines based on the conserved proteins shared between different serotypes are potential candidates for such a universally protective vaccine.